1.Comparison of clinical effects and safety of olanzapine and aripiprazole in the treatment of schizophrenia
Yaqing SHAO ; Zhaoyan JI ; Yanxiong SHEN
Chinese Journal of Primary Medicine and Pharmacy 2018;25(18):2383-2386
Objective To compare the clinical effects and safety of olanzapine and aripiprazole in the treatment of schizophrenia .Methods From February 2015 to February 2017 ,100 patients with schizophrenia were chosen in the Third People's Hospital of Yuyao .The patients were randomly divided into A group ( treated with olanzapine ) and B group ( treated with aripiprazole ) , with 50 patients in each group .The clinical efficacy , PANSS score,blood lipid levels and blood glucose level before and after treatment ,and the incidence of adverse effects of the two groups were compared.Results The total effective rates of A group and B group were 86.00%,90.00%, respectively,there was no statistically significant difference between the two groups (χ2 =1.36,P>0.05).There were no statistically significant differences in the PANSS scores after treatment between the two groups ( t=3.17,2.96, 4.21,2.75,3.56,4.01,4.55,4.49,4.71,5.07,4.26,4.92,all P>0.05).After treatment,the levels of FBG,TC and TG of A group were statistically significantly higher than those before treatment (t=3.04,2.68,4.01,P<0.05). The levels of FBG,TC and TG after treatment of B group were significantly lower than those of A group (t=4.81, 3.35,4.14,all P<0.05).The incidence rates of lethargy ,dizziness,insomnia,nausea,vomiting and constipation of A group were 28.00%,38.00%,8.00%,6.00%,36.00%,respectively,which of B group were 2.00%,10.00%, 12.00%,8.00%,10.00%,respectively,and the incidence rates of lethargy ,dizziness and constipation of B group were significantly lower than those of A group (χ2 =9.32,8.77,10.24,all P<0.05),and there was no statistically significant difference in the incidence rates of insomnia ,nausea and vomiting between the two groups (χ2 =2.16, 1.12,all P>0.05).Conclusion Olanzapine and aripiprazole in the treatment of schizophrenia possess the same clinical effects and safety;but aripiprazole can efficiently relieve the influence of blood lipid metabolism and reduce the risk of adverse drug reactions .
2.Expert Consensus on Facial Reanimation with Masseteric-to-facial Nerve Transposition (2023)
Wenjin WANG ; Wei WANG ; Zhigang CAI ; Tong JI ; Lianjun LU ; Song LIU ; Xuesong LIU ; Chengyuan WANG ; Zhaoyan WANG ; Zhen WU ; Chuan YANG ; Yasheng YUAN ; Chenping ZHANG ; Ping ZHONG
Chinese Journal of Microsurgery 2023;46(6):605-618
Facial paralysis causes both physical pain and psychological distress to patients. It is difficult for a patient with facial paralysis to engage with a normal social life and at work. Progresses have been made in recent years in the treatment of facial paralysis. More attentions have been caught by masseteric to facial nerve transposition, which has advantages of adjacency in location, abundancy in nerve supply and reliability in the outcome and now has deemed an important option of facial reanimation. It has not been long since the application of the technique of masseteric to facial nerve transposition in China, therefore it still lacks a universal guidance on practice. In order to achieve the aim of better quality control and popularisation of the technique, hereby a consensus with suggestions on facial reanimation with masseteric to facial nerve transposition is proposed as the reference for surgeons specialised in facial reanimation. This consensus is proposed, discussed and drafted by experts from plastic and reconstructive surgery, oral and maxillofacial surgery, head and neck surgery and neurosurgery.