Objective: To evaluate the efficacy of Yinlian gargle combined with Sodium bicarbonate on treatment of adult with oral fungal infections of acute myeloid leukemia chemotherapy Induced myelosuppression. Methods: Totally 120 patients with acute myeloid leukemia for chemotherapy Induced myelosuppression complicated with oral fungal infections were randomly divided into the western medicine group, the traditional Chinese medicine (TCM) group, the integrated TCM and western medicine group and the control group, with 30 patients in each group. The integrated TCM and western medicine group was treated by Yinlian gargle and sodium bicarbonate solution alternately, the TCM group was treated by Yinlian gargle, the western medicine group was treated by Yinlian gargle and sodium bicarbonate solution, and the control group was treated by basic treatment and normal saline 4 times a day for 5 days. Before and after treatment, the Oral pH, white spot area, the safety were observed. And to calculate the total efficiency of each group. Results: The oral pH (6.98 ± 0.13 vs. 6.57 ± 0.14, 6.61 ± 0.11, 6.23 ± 0.09, F=273.930 )in the integrated TCM and western medicine group were significantly higher than those among other groups (P<0.05). The white spot area (2.21 ± 1.93 mm² vs. 6.32 ± 2.35 mm², 5.99 ± 2.64 mm², 7.83 ± 2.56 mm², F=29.842) in the integrated TCM and western medicine group were significantly lower than those among other groups (P<0.05). The effective rate in TCM and western medicine group was 96.7% (29/30), TCM group 60.0% (18/30), western medicine group 63.3% (19/30), and the control group 31.0% (9/29), which showed significantly difference among four groups (χ²=27.425, P<0.01). Conclusions The Yinlian gargle combined with sodium bicarbonate on treatment of adult acute myeloid leukemia chemotherapy induced myelosuppression with oral fungal infections was effective.