1.Effect of quality control circle to reduce intraoperative hypothermia during transurethral resection or prostate for elderly patients
Yan CHEN ; Yue ZHANG ; Zhaorong LU ; Ping HUANG
Chinese Journal of Modern Nursing 2014;20(36):4616-4619,4620
Objective To explore the effect of quality control circle ( QCC) to prevent intraoperative hypothermia during transurethral resection or prostate ( TURP) of aging patients .Methods We founded QCC team, utilized PDCA, and established ‘To prevent Intraoperative hypothermia during TURP of elderly patients ’ as a theme.Elderly, who met the sampling criteria and implement of TURP from January to October 2013 were assigned, for stock taking, setting goals, analyzing the causes, implementing rectification measures and evaluating the effect .Results Through the QCC , the rates of intraoperative hypothermia ,chills and postoperative agitation (14.3%,13.4%and 8.9%) were significant differences before QCC carried out (41.6%,30.9%and 21.4%) (χ2 =18.694,12.311,6.125,respectively;P<0.05).Each member of QCC was improved in the use of QCC, teamwork, expertise, relationships, the power of executive and the ability to resolve problems . Conclusions To carry out the quality control circle activity in elderly patients with TURP can effectively reduce the intraoperative hypothermia occurs , reduce intraoperative shivering and agitation and other complications , and improve the ability of team members to use QCC problem .
2. Effect of lienal polypeptide injection on primary immune thrombocytopenia
Zhaorong YUE ; Hongyu LI ; Fei XIE ; Xin WANG ; Hongyu LI
Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(11):1229-1236
AIM: To explore the effect of lienal polypeptide injection (LPI) on platelet production in ITP model mice with primary immune thrombocytopenia. METHODS: SPF Kunming mice were divided into groups by random number table method, and the ITP model of mice was induced by intraperitoneally injected of rabbit anti-mouse platelet serum APS every other day. At the set time, blood was collected through caudal vein to detect the changes in the number of platelets, red blood cells and white blood cells in each group. Meanwhile, the thymus and spleen indexes were calculated. Megakaryocytes were classified and counted by means of bone marrow smear. Finally, the expression levels of TPO, SCF, IL-3, IL-6, IL-11, β-TG, TGF-β1 and PF-4 in serum were detected by ELISA. RESULTS: LPI significantly increased platelets count in ITP model mice, but had no effect on red blood cells and white blood cells. Thymus and spleen index decreased significantly. The number of megakaryoblasts and thrombocytopenia megakaryocytes in the bone marrow of mice increased, but the number of promegakaryocytes, granular megakaryocytes and naked megakaryocyte did not change significantly. Serum sytokines SCF, IL-3 and IL-6 were significantly increased, while PF-4 was decreased significantly. CONCLUSION: LPI may increase the platelet count in ITP mice by up regulating the levels of IL-3, IL-6, SCF and down regulating the level of PF-4, which has guiding significance for clinical promotion application of LPI.