1.Construction and prospection of percutaneous coronary intervention quality control system
Tianjin Medical Journal 2015;(8):833-836
In 21th century, percutaneous coronary intervention (PCI) technique enters in rapid development stage in China. From 2009, quality control system of PCI runs in national scale. Since then, the national quality control center estab?lished cooperative relationship with the provincial quality control centers. Official website and quality control tools were im?proved. PCI data were collected and analyzed annually, and then reported to the regulatory body and published to the public. Audit was run irregularly. Quality control centers were also involved in some other related affairs such as training course and admission. The quality control system lead PCI in China to an improved daily practice and control PCI application all overthe country in terms of data. In the future, the quality control techniques and teamwork will be further improved. And quality evaluation system and management team will be perfected gradually. Quality control will be extended from PCI to coronary heart disease and combined with audit of coronary heart disease. According to the quality control data, the quality and its rank of medical centers will be published in certain range. So that we can provide better care to the coronary heart disease pa?tients.
2.Cholesterol crystal embolism after coronary intervention
Lei MENG ; Yong HUO ; Zhaoping LIU
Chinese Journal of Interventional Cardiology 1996;0(04):-
Objective To analyze the clinical characteristics of patients with cholesterol crystal embolism (CCE) after percutaneous coronary intervention. Methods Six patients with atherosclerosis presenting with simultaneous occurrence of acute renal failure and peripheral ischemic changes were diagnosed as cholesterol crystal embolism and their clinical data were analyzed. Results The patients, 5 men and 1 woman, had an average age of 72 years. Most of them had risk factors of atherosclerosis such as hypertension, diabetes and smoking. The levels of serum creatinine increased progressively after coronary angiography. All patients had concomitant skin lesions, including blue toes. Cutaneous biopsy of 1 patient found cholesterol emboli in arterioles. All patients received statins, and 2 received dialysis. Three patients died, and 3 patients remained chronic renal failure. Conclusion Since the morbidity of CCE is growing and the disease is iatrogenic in origin, special attention should be paid to this disease.
3.Factors influencing outcomes of patients with acute myocardial infarction receiving primary percutaneous coronary intervention
Weishan LI ; Zhaoping LIU ; Jianping LI
Chinese Journal of Interventional Cardiology 1996;0(01):-
360 min,the risk of no-reflow phenomenon was decreased in patients with SOTB≤360 min(OR=0.2,95% CI:0.0-1.0,P=0.045).(2) Obesity was identified as an independent risk factor for peak concentration of CK-MB(?=117.3,95% CI:12.1-222.6,P=0.029).(3) Age(above 60 years old),obesity,and preprocedural Killip classification were identified as independent risk factors for postprocedural LVEF.Old age(?=-6,95% CI:-9.7--2.2,P=0.002) and obesity(?=-3.8,95% CI:-7.6--0.1,P=0.044)were associated with low LVEF but preprocedural cardiac function of Killip Class Ⅰ was associated with high LVEF(?=4.9,95% CI:0.4~9.4,P=0.033).(4) Preprocedural Killip classification and multivessel disease were independent predictors for major adverse cardiac event in the follow-up period.The risk of major adverse cardiac event during follow-up decreased in patients with preprocedural Killip class I compared with patients with Killip class Ⅱ~Ⅳ(OR=0.1,95% CI:0.0-0.7,P=0.022),but the risk increased in patients with multivessel disease compared with those who had single vessel disease(OR=10.5,95% CI:1.1-99.4,P=0.041).Conclusion The clinical outcomes and prognosis of patients with AMI treated with primary PCI were associated with a variety of risk factors including age,obesity,multivessel disease,and preprocedural cardiac function.In addition,SOTB was related to postprocedural TIMI flow in patients with AMI undergoing primary PCI.
4.Premature coronary heart disease in female:clinical and coronary angiography features
Zhaoping LIU ; Tao HONG ; Jianping LI
Chinese Journal of Interventional Cardiology 1996;0(01):-
Objective To explore the clinical and coronary angiography features of female patients suffering from premature coronary heart disease by analyzing retrospectively the clinical data of those women who undertook coronary angiography before 55 years old in a period of 5 years. Methods Female patients under 55 years were enrolled. Data such as risk factors (including hypertension, diabetes, hyperlipidemia, stroke, and metabolic syndrome), clinical findings (including blood pressure, serum lipid test on admission), and coronary angiographic images were collected to find the relationship between risk factors and coronary heart disease. Results The study had enrolled 166 cases with 71 cases (42.8%) of them diagnosed as coronary heart disease. In this group, the most important risk factors were diabetes, metabolic syndrome, history of hypertension, high level of serum TG and decreased HDL. At the same time, we found that the body mass index, LDLC level, TG level and blood glucose in CHD patients were significantly higher than those in non-CHD ones. Single vessel disease was the most popular pattern of these CHD patients. Conclusion History of diabetes, metabolic syndrome and hypertension were the most vital risk factors of CHD in this relative young female population.
5.Clinical study of aspirin resistance in patients with metabolic syndrome
Yang YU ; Zhaoping LIU ; Xinhua WANG
Chinese Journal of Practical Internal Medicine 2006;0(16):-
Objective To investigate the prevalence of aspirin resistance(AR)in the patients with metabolic syndrome and the clinical characteristics.Methods A total of 221 patients with metabolic syndrome received 200 mg of aspirin daily for 10 days and no other antiplatelet agent.The blood samples were analyzed by platelet aggregation test(pAgT)using arachidonic acid(AA).We identified aspirin resistance when arachidonic acid induced aggregation≥20%.Results 17.6%of the patients showed AR.The AR fibrinogen level was significantly higher than AS patients(2.6?0.4 vs 2.4?0.4,P=0.017).Patients who were AR had no statistically significant difference in blood pressure,age,fasting blood glucose,blood fat and BMI compared with aspirin-sensitive patients(AS).There was also no difference in sex,smoking and history of myocardial infarction or ischemic stroke between AR and AS patients.When stratified by sex,we found history of myocardial infarction was predictor for AR in male(50.0% vs 14.5%,P=0.020)and so was diastolic blood pressure higher than 85mmHg in female(34.0% vs 15.5%,P=0.043).Conclusion The AR accounts for 17.6%(39/221)of all.In this research.AR patients have higher level of fibrinogen than AS.History of myocardial infarction and higher level of diastolic blood pressure may be the predictor for AR in male and female individually.
6.Assessment of trans-fatty acids intake via bakery food among above three-year-old population in Beijing and Guangzhou city
Jianwen LI ; Aidong LIU ; Lei ZHANG ; Zhaoping LIU ; Ning LI
Chinese Journal of Pharmacology and Toxicology 2014;(2):283-289
OBJECTIVE To investigate trans-fatty acids (TFA)contents in bakery food and assess TFA intake via bakery food and its energy contribution in Beijing and Guangzhou city.METHODS Bak-ery food sa mples were collected in 201 1 ,standard GC-method were used to determine TFA content,da-ta of TFA content were analyzed by t-test to evaluate for statistically significant differences.Si mple distri-bution model(determinative risk assess ment)of TFA intake was used to calculate individual TFA intake per day(g·d -1 ,% of total energy)in different populations(grouped by ages).RESULTS Average TFA content was ranging fro m 0.01 to 0.83 g /100 g sa mple in various kinds of bakery food.TFA con-tents were equal to or lower than 0.3 g /100 g in 77.1 % of biscuits,71 .8% of bread,67.0% of pas-tries.Wafer biscuit,sandwich biscuit,puff,cake,and croissants had higher TFA contents than others, and the level was 0.65 -0.83 g /100 g sa mple.TFA content in sandwich biscuit and pie decreased sig-nificantly after 2007.Average TFA intake via bakery food was 0.049 g·d -1 in Beijing and Guangzhou city,energy contribution was 0.027% which was far below the WHO reco mmended level (1 %). Population that are 3 to 6 years old had highest TFA intake and the TFA energy contribution was 0.041 %.CONCLUSION Most of bakery products in China contained low levels of TFA;consequently, health risk caused by TFA intake in Beijing and Guangzhou was unlikely to be a concerned.However, so me type of bakery foods had higher TFA contents which could be of greater concerned for risk management.
8.Sensitivity in typeⅠ hypersensitivity compared between BN rats and Wistar rats
Zhonggang LI ; Huidi QIN ; Huaishan WANG ; Yanqiu SHI ; Zhaoping LIU
Chinese Journal of Pharmacology and Toxicology 2010;24(1):30-34
OBJECTIVE To compare sensitivity in typeⅠ hypersensitivity between BN and Wistar rats, and to establish a sensitive and reliable determination system for typeⅠ hypersensitivity. METHODS BN and Wistar rats were sc given ovalbumin (OVA) 10, 20 and 40 μg·kg~(-1) every other day for 5 times and normal control group with sc normal saline. The total immunoglobulin E (IgE) levels in serum were determined with ELISA and the specific IgE levels in serum were determined by passive cutaneous anaphylaxis on the 21st day from the 1st injection. The blood pressure, serum histamine and tryptase levels were determined after challenge on the 22nd day. RESULTSTotal IgE, specific IgE, histamine and tryptase levels in serum significantly increased and blood pressure decreased in OVA 10, 20 and 40 μg·kg~(-1) BN rat groups compared with normal control group, while in Wistar rats these symptoms only appeared in OVA 40 μg·kg~(-1) group. CONCLUSION BN rats are more sensitive than Wistar rats in typeⅠ hypersensitivity. The blood pressure, serum total IgE, specific IgE, histamine and tryptase levels can be used as the important indicators in typeⅠ hypersensitivity.
10.Development of Optometer Controlled by Micro-computer
Zhaoping GUO ; Zujin ZHANG ; Hui LI ; Dapeng LIU ; Hongyuan ZHANG
Chinese Medical Equipment Journal 1993;0(05):-
Objective To develop a new optometer controlled by micro-computer.Methods With AT89C51 single-chip as hardware and programmed by C language,the instrument applied,the optometer adopted LCD and international standard optotype.The optotype had 14 lines of object-finders,and only one line of random characters was displayed on the screen every time.The optometry distance was 3m.All procedures were controlled by singlechip.Results The case of memorizing eye-chart was avoided and the optometry was every simple.Conclusion The instrument eliminates mirror used for optometry short distance,and the optometry results can be stored and printed.It also has the merits of small volume,precise manufacture,simple operation,low cost and AC/DC power supply.