Objective To evaluate the feasibility of a new reduction technique by comparing 2 reduction strategies in the treatment of distal femoral fractures with less invasive stabilization system (LISS).Methods A retrospective study was performed on the clinical data of 31 patients with distal femoral fracture who had been treated with LISS at Department of Orthopedics,Huadong Hospital Affiliated to Fudan University from January 2014 to December 2016.They were 11 males and 21 females.In 21 of them reduction of the fracture ends was conducted before fixation of the distal femur (strategy one),involving 9 males and 12 females with an age of 73.2 ± 16.2 years;in the other 10 of them reduction of the fracture ends was conducted after fixation of the distal femur (strategy two),involving 2 males and 8 females with an age of 70.8 ± 20.4 years.The 2 groups were compared in terms of perioperative blood loss,operation time,postoperative complications and the modified Hospital for Special Surgery (HSS) score of the affected knee joint.The enumeration data were compared with Fisher exact test and the measurement data with t-test.Results The 2 groups were compatible due to the insignificant differences in their preoperative general data (P ＞ 0.05).There were no significant differences between the 2 groups in terms of perioperative blood loss (593.3 ± 99.1 mL versus 494.7 ± 94.4 mL),operation time (121.7 ± 8.1 min versus 106.4 ± 8.5 min),rate of postoperative complications (0 versus 10％) and modified HSS score of the affected knee joint (83.8 ± 1.4 versus 84.2 ± 3.1) (P ＞ 0.05).Conclusions The 2 reduction strategies can lead to similar surgical effects in the treatment of distal femoral fractures with LISS.Strategy two can be a feasible alternative for surgeons with its theoretical advantage of simplicity.