Objective:To explore the effect of Hejie Jusan Decoction on pyroptosis in diabetic nephropathies (DN) rats; To explore its mechanism based on the NF-κB/nucleotide binding oligomeric domain like receptor protein 3 (NLRP3)/Caspase-1 signal pathway.Methods:Totally 60 SD rats were divided into blank group, model group, potassium losartan group, and Hejie Jusan Decoction high-, medium-, and low-dosage groups. In addition to the blank group, the other five groups were established DN rat models. Hejie Jusan Decoction high-, medium-, and low-dosage groups were given 0.5, 1.0, and 2.0 g/ml concentrations of Hejie Jusan Decoction, respectively; the potassium losartan group was orally administered with 20 mg/kg potassium losartan; The blank group and model group were given equal volumes of physiological saline by gavage, once a day, for consecutive 28 days. After medication, the levels of serum creatinine (SCr), urea nitrogen (BUN), and 24-hour urine protein (24 hUP) were detected; pathological changes in renal tissue were detected by HE staining; Western blot method was used to detect the expressions of P65, NLRP3, Caspase-1, and GSDMD protein in renal tissues.Results:Compared with the model group, the SCr, BUN, and 24-hUP of rats in the Hejie Jusan Decoction high-dosage group and the potassium losartan group decreased ( P<0.01). The expressions of P65, NLRP3, Caspase-1, and GSDMD protein in renal tissues of Hejie Jusan Decoction groups and potassium losartan group decreased ( P<0.05 or P<0.01). Conclusion:Hejie Jusan Decotion may affect pyroptosis by inhibiting the activation of NF-κB/NLRP3/Caspase-1 pathway, reducing renal function damage and pathological changes, so as to achieve the effect of treating diabetes nephropathy.

Objective? To explore the influence of nurses' self-job competence and coping style on nurses' job burnout, and to provide guidance for nurses' occupational health. Methods? From February to September of 2017, a total of 367 nurses from three hospitals of Huzhou City were recruited in a cross-sectional survey. The Chinese version of the Six Dimension (6-D) Scale of Nursing Performance was used to measure the competency of nurses. The General Coping Style Scale were used to measure the coping style of nurses. Maslash Burnout Inventory-Human Service Survey (MBI-HSS) was used to assess the job burnout of nurses, and analyze the relationship between job competency, coping style and job burnout of nurses. A total of 367 questionnaires were distributed in this study, 301 valid questionnaires were collected, and the effective recovery rate was 92.33%. Results? In general coping style scale, the positive coping score of the 301 nurses was (1.68±0.61) and the negative coping score was (1.93±0.74). The 6-D scale were negatively correlated with emotional exhaustion, depersonalization and positive coping style in MBI-HSS (P＜0.05), positively correlated with personal emotion and positive coping style (P＜ 0.05). The coping style of nurses plays a mediating role in the influence of job competency on job burnout. The path coefficient of job competency on job burnout was 0.62 (P＜0.001). Job competency could explain 57.31% of job burnout variance. The path coefficient of coping style to job burnout was -0.41.The path coefficient of coping style to job burnout was -0.41 (P＜0.001). The path coefficient of job competency to job burnout was -0.51 (P＜ 0.001). Job competency and coping style could explain 21.57% variance of job burnout. The indirect effect of job competency on job burnout through coping style was -0.25(P＜0.001). Conclusions? The coping style makes part of the mediating effect on the relationship between job competence and job burnout. Nursing managers and educators should improve the competency of nurses in various aspects such as job competency training, coping style training, and so on. These may help nurses improve their positive coping style and reduce their professional burnout.

Objective To compare the effect on the flow conditions of adhesives and the retention force of restorations among different cement?retained methods of implant?supported fixed prostheses. Methods Four common cement?retained methods were selected, including the occlusal hole for screw access (OH), the lingual hole for adhesives overflow (LH), the resin replica for titanium abutment (RR), and the traditional cement?retained method (the control group). The adhesive used in this study was resin?modified glass ionomer cement. The two?dimensional analysis models of computational fluid dynamics (CFD) were established. The flow conditions of adhesives in the adhesion process was analyzed by the CFD analysis. The internal filling ratio and the amount of neck overflow of adhesives below the edge of the prosthesis were calculated. Ten zirconia prostheses in each group were processed and cemented. The retention force was examined by mechanical tensile experiments in vitro . Results The CFD analysis showed the internal filling ratio of adhesives from high to low was the LH group, the OH group, the RR group and the control group. The amount of neck overflow of adhesives below the edge of the prosthesis from less to more was the RR group, the OH group, the LH group and the control group. The retention force was (240.7± 33.9) N in the control group, (278.2±59.1) N in the OH group, (292.9±47.9) N in the LH group, and (262.8± 59.4) N in the RR group. There was a statistically significant difference in the retention force between the LH group and the control group (P=0.029). There was no significant difference among the other groups (P> 0.05). Conclusions The modified cement?retained methods can effectively reduce the amount of neck overflow of adhesives, and improve the filling condition of adhesive in the adhesive clearance to ensure the retention force of the prostheses. Clinically, the appropriate modified cement?retained method should be selected according to the three?dimensional position of the implant and the position of prosthetic margin.

Objective To study the safety and effectiveness of chloral hydrate in children undergoing ABR tests.Methods From December 2015 to March 2022,5 513 children under the age of 12 were selected for ABR ex-amination in West China Hospital of Sichuan University,who received chloral hydrate sedation(dose of 30 mg/kg).Data on administration method(mixed or direct),sleep deprivation(yes or no),failure performance(such asfailure to sleep,insufficient sedation,superficial sleep),adverse events(vomiting,irritability,etc.)were retrospectively analyzed.Total sedation failure rate,sedation failure rates in different age groups(≤0.5 years,0.5～3 years,3～12 years)and adverse event rate were calculated.Results Among the 5 513 ABR tests,199(3.61％)failed seda-tion.The sedation failure rates in different age groups(≤0.5 years,0.5～3 years,3～12 years)were 3.03％,4.31％and 3.11％,respectively.In the sedation failure tests,insufficient sedation was found in 81.91％of the tests.The incidence of adverse events was 10.55％,with most commonly vomiting.Conclusion The sedation fail-ure rate and the incidence of adverse events of chloral hydrate at 30 mg/kg were relatively low,thus chloral hydrate can be considered safe and effective at this dose.

Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension. Methods: Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosed according to the guidelines issued by the American College of Cardiology/American Heart Association in 2017. Results: The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in females or subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP) were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely related with SCH in female subjects aged <65 years. Conclusion The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BP components in females younger than 65 years.

Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension. Methods: Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosed according to the guidelines issued by the American College of Cardiology/American Heart Association in 2017. Results: The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in females or subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP) were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely related with SCH in female subjects aged <65 years. Conclusion The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BP components in females younger than 65 years.

Objective: To compare the effect on the flow conditions of adhesives and the retention force of restorations among different cement-retained methods of implant-supported fixed prostheses. Methods: Four common cement-retained methods were selected, including the occlusal hole for screw access (OH), the lingual hole for adhesives overflow (LH), the resin replica for titanium abutment (RR), and the traditional cement-retained method (the control group). The adhesive used in this study was resin-modified glass ionomer cement. The two-dimensional analysis models of computational fluid dynamics (CFD) were established. The flow conditions of adhesives in the adhesion process was analyzed by the CFD analysis. The internal filling ratio and the amount of neck overflow of adhesives below the edge of the prosthesis were calculated. Ten zirconia prostheses in each group were processed and cemented. The retention force was examined by mechanical tensile experiments in vitro. Results: The CFD analysis showed the internal filling ratio of adhesives from high to low was the LH group, the OH group, the RR group and the control group. The amount of neck overflow of adhesives below the edge of the prosthesis from less to more was the RR group, the OH group, the LH group and the control group. The retention force was (240.7±33.9) N in the control group, (278.2±59.1) N in the OH group, (292.9±47.9) N in the LH group, and (262.8±59.4) N in the RR group. There was a statistically significant difference in the retention force between the LH group and the control group (P=0.029). There was no significant difference among the other groups (P>0.05). Conclusions The modified cement-retained methods can effectively reduce the amount of neck overflow of adhesives, and improve the filling condition of adhesive in the adhesive clearance to ensure the retention force of the prostheses. Clinically, the appropriate modified cement-retained method should be selected according to the three-dimensional position of the implant and the position of prosthetic margin.