Objective To study the application of remifentanil combined with sevoflurane or propofol in the anesthesia of patients with intracranial tumors.Methods From January 2015 to December 2015,60 patients with intracranial tumor surgery in our hospital were selected as the research object in this study.They were randomly divided into A group and B group,each group had a total of 30 cases.Patients in group A were treated with remifentanil combined with sevoflurane anesthesia,and B group was treated with remifentanil and propofol anesthesia.Comparative analysis of A group and B group of patients with clinical indicators.Results During the operation,two groups of patients with end tidal carbon dioxide partial pressure and pulse oxygen saturation score.Two groups of patients in the immediate intubation heart rate and blood pressure were significantly lower than before anesthesia,A group reduced the degree of greater,with statistical difference(P<0.05).In group A,30 min and 1H were significantly higher than those in group B after anesthesia,and the difference was statistically significant(P<0.05).The anesthesia time of A group was(187.3±22.7)min,and the extubation time was(22.1±8.2)min.The anesthesia time of B group was(181.4±19.1)min,and the extubation time was(10.2±5.3)min.As a result,B group of patients with anesthesia time and extubation time were significantly less than the A group,and with statistical difference(P<0.05).Conclusion Remifentanil Combined with propofol and sevoflurane anesthesia in patients with intracranial tumors compared to two kinds of methods can effectively stabilize the patient's life signs,but remifentanil and propofol recovery time is fast,contribute to the balance of cerebral oxygen supply and consumption in a certain extent,with the further promotion and application of clinical significance.

Objective To study clinical and immunological features of renal tubular acidosis (RTA) patients complicated with autoimmunity disease. Methods Data of 60 patients of RTA complicated with autoimmune disease and 40 without it during 1999 and 2009 were reviewed, including clinical features,immunological examinations and renal tubular function. Results Among 60 patients of RTA, 59 were type Ⅰ, one type Ⅱ, and 55 complicated with Sjogen's syndrome (92%), one with systemic lupus erythematosus, nine with autoimmune thyroid disease, and one with rheumatoid arthritis. Flaccid paralysis was manifested in 50 (83%) RTA patients complicated with autoimmune disease, polyuria in 28 (47%),polydipsia in 28 (47%) , bone disorder in 24 (40%) and arthralgia in 28 (47%) cases, but of those without autoimmune disease, bone disease only in eight (20%) and arthralgia in nine (22%) cases, with statistically significant difference ( P ＜0. 01 ). Serum level of parathyroid hormone increased noticeably, with prevalence of positive antinuclear antibody, anti-SSA antibody and anti-SSB antibody of 88 % (49/56),84% (47/56) and 43% (24/56), respectively in RTA patients with autoimmune disease, all significantly higher than those in the patients without it ( P ＜ 0. 05 ). Conclusions Sjogen' s syndrome is the most common and prevalence of bone disorder and arthralgia are significantly higher in patients of RTA complicated with autoimmune disease, which should be examined as early as possible for timely diagnosis and treatment.