1.Contracted services of general practitioner improve management of primary hypertension in community
Chinese Journal of General Practitioners 2013;12(10):844-846
Two hundred and forty patients with primary hypertension in Weifang Community were randomly sampled as contract group and another 240 hypertensive patients were sampled as control group.Patients in contract group signed service contract with general practitioners (GPs),who provided individualized service for hypertension management.Patients in control group receive conventional outpatient service for hypertension management.The clinical data of patients before and one year after contracted services were documented and compared with those in control group.The results showed that in contract group the average systolic pressure decreased from 134.60 mm Hg (1 mm Hg =0.133 kPa) to 130.62 mm Hg (P =0.000),reaching-the-target-BP rate increased from 56.3% to 85.5% (P =0.000),serum total cholesterol and triglyceride decreased significantly one year after receiving contracted services (P =0.000) ; while these indicators were not significantly changed in control group (all P > 0.05).The results indicate that the contracted services of GPs can improve the effectiveness of hypertension management in community.
2.Study on policies to implement proper technology of traditional Chinese medicine in communities in central city of Shanghai
Chinese Journal of General Practitioners 2010;09(10):711-713
We studied policies of traditional Chinese medicine (TCM) on four levels ( national,Shanghai city, Pudong New District and community health services (CHS)) from 2008 to 2009 with the method of literature review,questionnaire survey and group interview. 18 national, 5 Shanghai's, 4 Pudong New District's and 87 CHS' TCM related policies were identified. By defining the development target,financial capability, human resource and proper technology of TCM care, those policies ensured and prompted the progression of community TCM services. Yet TCM policy fulfill in community remained lagged,and talent cultivating, medical insurance support and TCM participating in public health needed to be improved.
3.Advances on DNA methylation for noninvasive tumor molecular diagnosis
China Oncology 2001;0(03):-
DNA methylation is one of the most common epigenetic events in eukaryotic cell.Aberrant DNA methylation is tightly related to tumorigenesis.Recent evidence indicates that DNA methylation is a promosing biomarker for cancer.The cancer-associated DNA methylation events could be detected from serum(plasma),urine,stool and bronchoalveolar lavage,providing a new choice for noninvasive cancer diagnosis.In this review,we summarized the advances on DNA methylation for noninvasive cancer diagnosis.
4.Effect of atorvastatin on NF-?B/I?B signal pathway and inflammation factor expression in rabbit atherosclerosis
Chinese Pharmacological Bulletin 2003;0(11):-
Aim To explore the effect of atorvastatin on NF-?B/I?B signal pathway,P selectin and ICAM-1 expression in cholesterol-rich diet-induced rabbit atherosclerosis.Methods 24 New Zealand white rabbits were randomly divided into three groups: control group,high-cholesterol group and atorvastatin group.Nucleus NF-?B p65 and cytoplasma I?B? were detected with Western blot technique.Plasma P selectin was detected with Immunoradioassay.Immunohistochemistry was employed to detect the expression of ICAM-1.Results Compared with the control group,the expression of nucleus NF-?B p65,P selectin and ICAM-1 increased significantly and cytoplasma I?B? reduced in high-cholesterol group(P
5.The Relationship between Overweight' Obesity and Blood Pressure among Children Living in Urban Area Beijing
Songming DU ; Yanping LI ; Zhaohui CUI
Chinese Journal of Prevention and Control of Chronic Diseases 2006;0(03):-
Objective To study the relationship between overweight, obesity and blood pressure among children living in urban Beijing. Methods A total of 4 267 pupils aged 9~10 years were randomly selected. Overweight and obesity were defined by age and sex specific BMI classification reference for Chinese children. Hypertension was defined by age, sex and height specific reference for US children. Results The prevalence of overweight and obesity in boys was 19.4% and 21.2%, in girls was 10.9% and 12.1%, respectively. Mean levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP) have significant different between all study group. The total prevalence of high blood pressure (HBP) was 16.1% for boys and 15.2% for girls, while it was 36.4% and 41.3% among obese boys and girls, respectively. The prevalence of high systolic blood pressure (HSBP), high diastolic blood pressure (HDBP)and HBP gradually increased as weight increased. Compared with the normal weight group, OR(95%CI) for HBP of overweight and obese children were 2.6 (2.1~3.3) and 5.8 (4.7~7.0), respectively. Conclusion Obesity is positive correlation with hypertension in children aged 9~10years of Beijing, and the risk of hypertension was increased with their body weight.
6.Prevention and treatment of normal peifusion pressure breakthrough in the treatment of cerebral arteriovenous malformation
Zhaohui LI ; Chao DU ; Xingli ZHAO
International Journal of Cerebrovascular Diseases 2009;17(12):918-921
Normal perfusion pressure breakthrough is a serious complication that may occur in the treatment of cerebral arteriovenous malformations. This article reviews the progress in research on normal perfusion pressure breakthrough in recent years. It mainly investigates its pathogeneses, predictive methods and prevention and treatment strategies.
7.Several Points in Ethic Review in Drug Clinical Trials
Yanping DU ; Zhaohui WANG ; Zhongqi YANG ; Keer HUANG ; Shaoxiang XIAN
Chinese Medical Ethics 1995;0(04):-
In order to protect the trial subjects' rights and benefits in drug clinical trials,we must pay special attention to the risk and benefit of the trial subjects(striving to minimize the risk and maximize the benefit),ensure the trial subjects' complete realization of the clinical trials and the successive informed consent,pay special attention to the protection of the specific trial subjects,and avoid the conflict of interests.
8.The construction of fever sentinel clinic in Shanghai community health service institutions
Haitang WANG ; Zhaohui DU ; Yan DING ; Xiaoming SUN
Chinese Journal of General Practitioners 2021;20(5):545-548
During the COVID-19 outbreak,the fever sentinel clinics were set up in Shanghai community health service institutions, based on the experience of Public Health Preparedness Clinic (PHPC) in Singapore. It is a successful case of rapidly transforming existing medical resources into the emergent use for epidemic prevention and control. This article summarizes the necessity and feasibility of setting up a fever sentinel clinic; the functional orientation, hardware and software configuration and operation mechanism of the fever sentinel clinic in different periods according to the operation results. Meantime, the article also proposes suggestions for future improvement of establishing fever sentinel clinic in different regions in China.
9.Clinical assessment of the treatment for pulmonary artery sling combined with anomalous bronchial branching and congenital tracheal stenosis
Xiaoqi SONG ; Xinwei DU ; Shunmin WANG ; Zhaohui LU ; Zhiwei XU
Chinese Journal of Thoracic and Cardiovascular Surgery 2021;37(2):79-83
Objective:To summarize the morphological characteristics and clinical experience of pulmonary artery sling(PAS) combined with anomalous bronchial branching, and provide new considerations for surgically treating PAS.Methods:A retrospective review of surgical experience of all patients with anomalous bronchial branching from January 2012 to December 2018 at Shanghai Children's Medical Center was conducted. There are 4 types according to the morphology of anomalous bronchial branching: tracheal bronchus, bronchial trifurcation, bridging bronchus, tracheal bronchus combined with bronchial trifurcation. The proportion of patients with anomalous bronchial branching combined with PAS was counted. The rate of tracheoplasty for four types was determined. We measured the interbronchial and subcarinal/subpseudocarinal angles before and after tracheoplasty.Results:140 patients were included in our study. The tracheal diameter of 11(21%, 11/53) patients with tracheal bronchus and 4(9%, 4/44) patients with bronchial trifurcation was normal. Among these patients, 125 patients had congenital tracheal stenosis(CTS). 115 patients underwent tracheoplasty. The rate of tracheoplasty of bridging bronchus was higher than tracheal bronchus(100% vs. 60%, P=0.000). One-stage surgery was performed in 76(61%) patients who had PAS. The interbronchial and subcarinal/subpseudocarinal angles were significantly reduced postoperatively( P=0.000). Conclusion:It is difficult to explain merely with vascular compression in patients with PAS with CTS and anomalous bronchial branching. One-stage slide tracheoplasty is currently the optimal option.
10.Determination of cognition function and sleep status in goungsters with internet addiction disorder and correlation analysis
Yunhong DU ; Ning ZHANG ; Junlin MU ; Zhaohui ZHANG ; Ruiling ZHANG
Journal of Jilin University(Medicine Edition) 2014;(4):884-887
Objective To explore the changes of cognition and sleep status in the youngsters with internet addiction disorder (IAD), and to clarify the relation between cognition and sleep-related indicators of IAD youngsters.Methods Event related potential (ERP) and Pittsburgh Sleep Quality Index (PSQI)test were used for forty-two IAD (case group)and forty non-IAD (control group) in youngsters, and the indexes of period latency (PL)of N1 ,P2 ,N2 ,P3 and amplitude of P3 (P3 amp)of ERP were analyzed,the factor scores of sleep quality (SQ), sleep latency (SL), sleep time (ST), sleep efficiency (SE), sleep dysfunction (SD), sleeping pills (SP), daytime dysfunction (DD)and total score of PSQI were analyzed. The correlation between the P3 PL, P3 amp of ERP and all the indexes of PSQI in case group was analyzed.Results The PL of N2 ,P3 of ERP in case group was significanly longer and the P3 amp was significantly lower than those in control group (P<0.01);the factor scores of the SQ,SL,ST,SE,SD,DD,and the total score of PSQI test had significant differences between two groups (P<0.01).The correlation analysis results showed that there were remarkable positive correlations between the P3 PL and the factor seores of the SQ,SL,ST,SE,SD,DD and the total score of PSQI test in case group (r=0.46,0.34,0.51,0.40,0.48,and 0.54;P<0.01),and there were remarkable negative correlations betweeb P3 amp and the indexes of PSQI test in case group (r=-0.42,-0.45,-0.49,-0.38,-0.38,and -0.50;P<0.01).Conclusion The IAD youngsters have cognition and sleep dysfunction,and the both factors can affect each other.