Objective To observe the curative effect that treating and mitigating reflux esophgitis with omeprajoh and mosapride. Methods one hundred and six patients were divided into three groups. The fwst group(36 case) were treated with omeprajole and mosaprid. The second group(35 sides) were treated with omeprajole. The third group(35 sides) were treated with mosapride. The change in symptom and endoscope before and after treatment were observed. Results After treated for two week and four week,the first group was better than second and third group. There was significant difference between first group and second group or third group(P<0.05). When eight week, the symptom had been improved obviously in first group(P< 0.05). Esophageal mucosa erosion was coalesce,the percentage was 86.1%, 62.9%,57.1%, there was significant difference(P < 0.05). Conclusion Omeprazole combined with mosapride is better in curing reflux esophagitis.