1.Traditional Chinese medicine combined with ozone in the treatment of 834 patients with knee joint osseous arthritis
Kezun LI ; Chunhong ZHANG ; Wei CUI ; Yongde PAN ; Zhaobo SONG
Chinese Journal of Primary Medicine and Pharmacy 2015;(z2):10-11
Objective To investigate the effect of comprehensive treatment in the treatment of knee osteoar-thritis by taking orally and external Chinese medicine with ozone injected the joint cavity.Methods 834 patients with knee osteoarthritis(1 212 knee joints)were randomly selected,after two courses of the comprehensive treatment,with excellent,good,fair and bad four levels to evaluate the therapeutic effect.Results After two courses of comprehensive treatment,534 cases were excellent,461 cases were good,181 cases were fair,36 cases were bad,the fine rate was 82.1%.Conclusion The comprehensive treatment is an effective method in knee osteoarthritis by taking orally and external Chinese medicine with ozone injected the joint cavity.
2.Budesonide/Formoterol in the Management of Patients with Mild or Moderate Asthma: Clinical Research
Juxiang ZHANG ; Xiuling GAO ; Shuhong LIU ; Suyin LI ; Zhaobo CUI
China Pharmacy 2007;0(26):-
OBJECTIVE: To evaluate the efficacy and the safety of low dose budesonide/formoterol combination therapy vs.medium dose of budesonide(BUD) dry powder in the management of mild or moderate adult asthma.METHODS: A total of 62 patients with asthma were randomized to Group A(budesonide plus formcterol) or Group B(budesonide).Main outcome measures: daytime symptom and nocturnal symptom,peak expiratory flow(PEF),number of times of using rapid-acting ? 2 agonist and its ADR.RESULTS: After treatment,both groups had significant improvement in daytime symptom and nocturnal symptom(number of times of wakeup),PEF value and lung function,and the dosage of rapid-acting ? 2 agonist was decreased,showing significant differences between the two groups.The ADR was light in degree.CONCLUSION: Inhalation therapy of low dose of glucocorticoid plus long-acting ? 2 agonist is an optimal choice in the management of asthma.The efficacy of glucocorticoid could be enhanced more by combination with low dose and long-acting ? 2 agonist than by simply increasing its own dose.
3.Surgical treatment for hilar cholangiocarcinoma
Zhaobo LIU ; Shichun LU ; Ning LI ; Dongdong LIN ; Wei LAI ; Menglong WANG ; Jushan WU ; Qingliang GUO
Chinese Journal of Digestive Surgery 2013;(3):186-190
Hilar cholangiocarcinoma (HCC) is a rare tumor with a poor prognosis.With the development of high definition imaging technology,improvement of surgical instruments,optimization of perioperative surgical strategies and accumulation of surgical experiences,the radical resection rate of HCC is significantly improved.Operation is the main method of treatment for HCC,and radical resection is important for a long-term survival of HCC patients.The clinical data of 66 patients with HCC who were admitted to the Beijing Youan Hospital from April 2004 to April 2012 were retrospectively analyzed.The key points in surgical procedure and prognosis of patients were investigated.
4.Advances in the prevention and treatment of hepatocellular carcinoma recurrence after liver transplantation
Journal of Clinical Hepatology 2021;37(2):267-271
Liver transplantation is an effective radical treatment method for patients with hepatocellular carcinoma (HCC), but HCC recurrence after liver transplantation seriously affects the long-term survival of patients receiving transplantation. Active preventive measures, adjustment of immunosuppressant, early identification of HCC recurrence, and development of comprehensive intervention measures after recurrence can help to improve the clinical outcome and long-term survival of HCC patients receiving liver transplantation. In order to further improve the prognosis of patients receiving liver transplantation, this article summarizes the latest research advances in the prevention and treatment of HCC recurrence after liver transplantation from the aspects of recurrence prevention and treatment after recurrence.
5.Safety of PD-1 inhibitor in preoperative treatment of liver transplantation for liver cancer
Zhaobo LIU ; Jushan WU ; Dongdong LIN ; Guangming LI
Organ Transplantation 2021;12(4):445-
Objective To evaluate the safety of programmed cell death protein 1 (PD-1) inhibitor in the treatment of primary liver cancer (liver cancer) before liver transplantation. Methods Clinical data of 7 recipients given with PD-1 inhibitor before liver transplantation for liver cancer were retrospectively analyzed. The incidence of immune-related adverse event (irAE) and clinical prognosis of the recipients were summarized. The safety of PD-1 inhibitor in recipients prior to liver transplantation for liver cancer was evaluated. Results Seven recipients were treated with PD-1 inhibitor with 1-20 courses before liver transplantation for liver cancer. The time interval from drug withdrawal to liver transplantation was 6-120 d. Five recipients suffered from irAE of different degrees, including fatigue in 3 cases, fever in 2 cases, alopecia in 2 cases, rash in 1 case, nausea in 1 case and myocarditis in 1 case, respectively. A majority of these irAE were classified as grade Ⅰ-Ⅱ. One recipient died from grade Ⅴ irAE (fatal myocarditis). One recipient developed rejection at postoperative 7 d, which were mitigated after glucocorticoid pulse therapy combined with increased dosage of tacrolimus. Conclusions PD-1 inhibitor can be applied in preoperative treatment before liver transplantation for liver cancer. Nevertheless, the incidence of irAE and postoperative rejection should be intimately monitored.
6.Prevention and treatment of hepatic artery dissection in donors and recipients during liver transplantation
Zhaobo LIU ; Zhenshun WANG ; Dongbin LIU ; Fei LI ; Jia LI ; Dongdong LIN
Organ Transplantation 2023;14(4):498-
Hepatic artery reconstruction is one of the key procedures in liver transplantation. Accidental dissection of the hepatic artery to be reconstructed caused by donor and recipient factors or surgical factors will disrupt the surgical plan, increase the difficulty of arterial reconstruction, significantly prolong the operation time, increase the risk of postoperative arterial stenosis and thrombosis and probably lead to acute allograft failure, which requires emergency surgical interventions or even secondary liver transplantation. Understanding of how to avoid dissection of the artery to be anastomosed during liver transplantation and corresponding treatment will contribute to preventing the incidence of artery-related complications during liver transplantation and improving clinical prognosis of liver transplant recipients. In this article, the causes, prevention and treatment of hepatic artery dissection and hepatic artery reconstruction in donors and recipients during liver transplantation were illustrated.
7.Role of live webcast as a new medium in the propaganda and education of liver transplant recipients
Xiaofei ZHAO ; Binwei DUAN ; Zhaobo LIU ; Jing ZHANG ; Qingliang GUO ; Guangming LI
Organ Transplantation 2020;11(6):719-
Objective To evaluate the role of live webcast as a new medium in the propaganda and education of liver transplant recipients. Methods According to the contents of live webcast propaganda and education meeting for liver transplant recipients, relevant data of the live webcast meeting were counted and analyzed, including baseline data of participants, participation pattern, viewing frequency and duration, etc. The characteristics between live webcast and traditional propaganda and education meetings were compared. Results By the end of the live webcast meeting, 273 participants were registered, including 2 oversea participants and 271 from China. These domestic participants were from 26 provinces, autonomous regions and municipalities in China. The total number of views was 1 526. Participants attended the meeting by clicking direct link (
8.The impact of splenectomy and esophagogastric devascularization on the nutrition status of patients with cirrhosis and portal hypertension
Daobing ZENG ; Chun ZHANG ; Liang DI ; Daming GAO ; Binwei DUAN ; Haitao ZHANG ; Qingliang GUO ; Qinghua MENG ; Lei LI ; Juan LI ; Xiaofei ZHAO ; Jushan WU ; Dongdong LIN ; Yunjin ZANG ; Zhaobo LIU ; Libo SUN ; Shichun LU
Chinese Journal of Hepatobiliary Surgery 2017;23(7):437-440
Objective To study the impact of splenectomy and esophagogastric devascularization on the nutritional status of patients with cirrhosis and portal hypertension.Methods Sixty consecutive patients with cirrhosis and portal hypertension who underwent splenectomy and esophagogastric devascularization at the Beijing YouAn Hospital from April 5,2015 to January 23,2017 were included in this study.The body mass index (BMI),albumin (Alb),prealbumin (PA) and lymphocyte counts were prospectively collected at the end of 1-week,1-month,3-month,6-month and 1-year after surgery.The postoperative results were compared with the preoperative results in these patients.Results The BMI results obtained at 1-week and 1-month after surgery were significantly lower than the preoperative level [(22.14 ± 3.08)kg/m2 vs.(22.85 ± 3.14) kg/m2,(21.72 ± 3.05) kg/m2 vs.(22.86 ± 3.16) kg/m2,P < 0.05].The BMI result at the end of 1-year after surgery was significantly elevated when compared with the preoperative level [(23.24 ± 3.64) kg/m2 vs.(22.68 ± 3.47) kg/m2,P < 0.05].The ALB levels at 1-month and 3-month after surgery were significantly higher than the preoperative level [(39.87 ± 4.22)g/L vs.(35.35 ±5.15) g/L,(39.35 ± 4.75) g/L vs.(34.82 ± 5.50) g/L,P < 0.05].The PA obtained at 1-week after surgery was significantly lower than the preoperative levels [(79.59 26.52)mg/L vs.(121.77 ±39.96)mg/L,P < 0.05].The lymphocyte counts at all the points after surgery were significantly higher than the preoperative level (P < 0.05).Conclusion Short term and long term nutritional status improved in patients with cirrhosis and portal hypertension after splenectomy and esophagogastric devascularization.
9.Protective Effect of Wenxin Prescription on Mitochondrial Energy Metabolism in Rats with Myocardial Ischemia-reperfusion Injury
Ying LIU ; Zhaobo WANG ; Li SHEN ; Hongxin CAO
Chinese Journal of Experimental Traditional Medical Formulae 2022;28(17):52-59
ObjectiveTo reveal the effect of Wenxin prescription on mitochondrial energy metabolism and silent information regulator 1 (SIRT1)/peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)/recombinant estrogen-related receptor α (ERRα) signaling pathway in rats with myocardial ischemia-reperfusion injury. MethodTotally 90 male Wistar rats of SPF grade were randomly assigned into a sham operation group, a model group, and low-, medium-, and high-dose Wenxin prescription groups, with 18 rats in each group. The rats in low-, medium-, and high-dose Wenxin prescription groups were administrated with 0.99, 1.98, and 3.96 g·kg-1 granules by gavage, respectively, and those in the sham operation group and model group with the same amount of normal saline. Twenty-one days after pre-administration, the rat model of myocardial ischemia-reperfusion injury was established by ligation of the left anterior descending coronary artery for 30 min and reperfusion for 2 h, and the rats in the sham operation group were only threaded without ligation. Myocardial infarction area was observed through 2,3,5-triphenyl-2h-tetrazolium chloride (TTC) staining, and the myocardial histopathology through hematoxylin-eosin (HE) staining. The levels of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) in serum, cytochrome C oxidase (CCO) and succinate dehydrogenase (SDH) in mitochondrion, and ATP in myocardial tissue were detected according to kit instructions. The mRNA and protein levels of SIRT1, PGC-1α, ERRα, and mitochondrial transcription factor A (TFAM) in myocardial tissue were determined by Real-time fluorescence quantitative polymerase chain reaction (Real-time PCR) and Western blot, respectively. ResultCompared with the sham operation group, the model group showed broken and disordered myocardial fibers, cytoplasmic edema, and pyknosis and deviation of nuclei. Moreover, the modeling increased the levels of CK-MB and LDH (P<0.05, P<0.01), lowered the levels of ATP, CCO, and SDH (P<0.05, P<0.01), and down-regulated the mRNA and protein levels of SIRT1, PGC-1α, ERRα, and TFAM in myocardial tissue (P<0.05, P<0.01). Compared with the model group, Wenxin prescription reduced the myocardial infarction area (especially in the high-dose group, P<0.01), restored the pathological changes, lowered the levels of CK-MB and LDH (P<0.05, P<0.01), increased the levels of ATP, CCO, and SDH (especially in the high-dose group, P<0.01), and up-regulated the mRNA and protein levels of SIRT1, PGC-1α, ERRα, and TFAM in myocardial tissue (P<0.05, P<0.01). ConclusionWenxin prescription can protect rats from myocardial ischemia-reperfusion injury by regulating myocardial mitochondrial energy metabolism via the SIRT1/PGC-1α/ERRα signaling pathway.