Objective To evaluete the effect of atorvastatin on reducing blood lipid in patients with coronary heart disease.Methods 150 cases of coronary heart disease patients collected in Liaocheng Third People’s Hospital of Shandong province from January 2013 to January 2014 were randomly divided into A,B two groups,each had is cases.Group A were treated with simvastatin,and group B were treated with atorvastatin.Blood lipid changes in two groups before and after treatment were compared. Results Compared with before treatment,the clinical sypotoms after treatment in two groups were allivate and TC,LDL-C indexes were significantly decreased (P <0.05 ).But there was no statistical significance between A and B groups. Conclusion Simvastatin and atorvastatin can effectively improve the blood lipid status in patients with coronary heart disease.