Objective To understand the current status of Oncomelania hupensis snails and the change rules,so as to pro?vide the evidence for formulating the snail control strategy. Methods The data of snails were collected and the factors influenc?ing the changes of snail status were investigated,and all the data were analyzed in Hailing District from 2007 to 2014. Results There were 18 environments with snails in 17 villages of 3 townships in Hailing District from 2007 to 2014. The snail area was 7.832 4 hm2. Among these environments and snail areas, 6 environments and 2.134 5 hm2, snail area were detected by the village snail investigation groups, and 12 environments and 5.697 9 hm2 snail area were detected by the township snail investigation groups. In addition, in 5 non?endemic villages, 3.126 3 hm2 snail area was found. In 2008, 2012 and 2013, a total of 2.274 0 hm2 snail area was found again. Conclusions In recent years,the snail situation rises again after schistosomiasis transmission has been interrupted. Therefore,this situation should be paid attention to.

High-consuming group is a special group which has good economic base, differmental culture and relgional belif customs. These patients alwanys need high quality medical service. How to integrate with these characteristics and make the nursing model of making patients' belife, moral ideas respcted, and rights proteded is a difficult problem. The author put forward we should rule nurse staff' s ethics and actions, provide a medical envionment from which can meet high-consuming patients physical and mental needs.

Objective To determine the mercury in seven kinds of algal plant drugs.Method The mercury in the samples was determined by the atomic fluorescence spectrometry after been digested by microwave.Results The detection limit of mercury was 0.045?g?L~(1).The relative standard deviation was 1.65% and the average recovery was 97.77%.Conclusion The method had the advantages of simple operation,higher precision,higher sensitivity and repeatability and was suitable for the determination of mercury in the algal plant drugs.

Objective To investigate the epidemiological characteristics of imported malaria in Hailing District ,Taizhou City,so as to provide the evidence for formulating the effective prevention and control strategy. Methods The network reports, questionnaires and epidemic reports of imported malaria cases in Hailing District from 2010 to 2015 were collected and analyzed retrospectively. Results From 2010 to 2015,totally 46 cases of imported malaria were reported,including 40 cases of falci?parum malaria(86.96%),4 cases of ovale malaria(8.70%),1 case of quartan malaria(2.17%)and 1 case of multi?infection of falciparum malaria and tertian malaria(2.17%). No seasonal trend of time of the disease onset was observed. All the patients were return abroad with clear residence histories in malaria epidemic areas. The average time from disease onset to definite diag?nosis was 2 d and 8 patients were definitely diagnosed within 24 h. All the 46 patients were cured. Conclusion All the malaria cases reported were imported cases in Hailing District in the last five years. Effective prevention and control measures are the key to the malaria elimination.

Objective: To establish a well reproducible and highly stable microembolic model in rat brains and to provide a platform for investigating the ischemic neuronal injury of microemboli. Methods: Fifty-four Sprague-Dawley rats were randomly assigned to sham-operation group (n = 10) and atherosclerotic plaque microembolic model group (n = 44). The latter were further redivided into 106-150 μm (n = 20), 75-105 μm (n = 12) and 55-74 μm (n = 12) groups according to the size of microemboli. Under the operating microscope, an indwelling venous catheter was inserted retrogradely from external carotid artery into internal carotid artery. Each rat was injected 100 corresponding microemboli of atherosclerotic plaque. The rats were killed after 24 hours. The severity of neuronal ischemic injury was detected by HE staining, the in situ TUNEL method for detection of apoptosis and immunohistochemistry staining for caspase-3 protein. Results: No infarction was found in the pathological section of brain tissue in the sham-operation group. The proportion of cerebral infarction in the 106-150 υm, 75-105 μm and 55-74 μm groups were 15/17, 11/12 and 5/12, respectively, there was significant difference as compared with the sham-operation group (P < 0.05); The numbers of TUNEL apoptosis were 33.3 ± 10.9, 25.9 ± 9.7 and 18.0 ± 6.9/HP, respectively, and they were significantly higher than those in the sham-operation group (5.7 ± 2.7/HP) (all P < 0.01). The cell numbers of positive expression of caspase-3 protein were 67 ± 11, 59 ± 12 and 46 ± 11/HP, respectively, and they were significantly higher than those in the sham-operation group (7.8 ± 3.1/HP) (all P < 0.01). Conclusion: The microemboli of 55-150 μm atherosclerotic plaque can stably result in microinfarction or neuronal apoptosis in rat brain tissues. The model may be used as an ideal means in the studying of physiopathology of cerebral microembolism.

OBJECTIVE: To synthesize N-(2, 3-dimethyl-2H-indazol-6-yl) -2-methylpyrimidinediamine derivatives and determine their antitumor activities in vitro. METHODS: Basing on the marketed multi-target antitumor agent, pazopanib, the objective substances were designed and synthesized according to the principle of fragment-based drug discovery. The antitumor activities in vitro of the synthesized compounds were evaluated by MTT method. RESULTS: Fourteen derivatives were synthesized. Their structures were identified by 1H-NMR, MS and elemental analysis. CONCLUSION: It is shown that most of the synthesized compounds have antitumor activities, among which compound B1 and B2 show better antitumor activity than the positive control.

Objective To investigate the rehabilitation training and education of one pair of twins with severe spasm type cerebral palsy(CP).Methods The rehabilitation training and education lasting 6 years was performed for one pair of twins(two girls with dysfunction in motion,one had basically normal intelligence,another one had poor intelligence).Results After rehabilitation training and education,the child with normal intelligence could walk by the help of crutch(initially,she could not sit independently)and study in a common learning environment with other child and gain a good performance record.Another child with low intelligence had very little improvement in motor function and intelligence.Conclusion By rehabilitation training and education,the children with cerebral palsy can minimize their disabled level on intelligence and recover their motor function.

Moral education has become gradually an important work of medical university in the new situation of market economy and knowledge economy. Toward characteristics of the college education of rehabilitation medicine, the current problems existing in the moral education of rehabilitation education was mainly analyzed, and new teaching method of moral education was probed as well as the understanding and thinking during the moral education.

According to the 'hygiene hypothesis', the intestinal microbes would not only regulate local immune status, but also affect systematic immune homeostasis, which may play an important role in the pathogenesis of allergic diseases. This review will mainly focus on investigating the intricate relationships among intestinal microbes, immune system and allergic diseases. Multiple factors affecting gut microorganisms may influence the immune homeostasis directly and later become risk factors of allergic diseases. This point of view may pave the way for the design of new interventions to the diseases.
Humans ; Hypersensitivity ; microbiology ; Intestines ; microbiology

Background The pre-chop technique can decrease the use of ultrasound power,and thus reducing the loss of corneal endothelial cells (CECs) and injuries of other intraocular structures.Many currently developed manual pre-chop techniques restrict the wide application of the pre-chop technique because of their intrinsic disadvantages.The present study describes a manual pre-chop technique for pre-slicing the lens nucleus by using a novel reverse chopper,which has not been reported yet.Objective This study was to compare the efficacy and safety of pre-chop technique using a reverse chopper and stop-and-chop phacoemulsification technique on Ⅳ degree hard nucleus cataract.Methods A prospective clinical-controlled interventional study was performed.Thirty-two eyes of 32 cataract patients with Ⅳ degree of nucles were enrolled in People's Hospital of Hetian District from March 2015 to January 2016.The patients were randomized into the prechop group and matched stop-and-chop group according to random number table.The self-made reverse chopper-assisted pre-chop phacoemulsification surgery and stop-and-chop phaco surgery were performed on the eyes of corresponding groups,respectively.The ultrasound power,effective phaco duration,corneal endothelium loss rate,the eye number of different grade of cornea edema after operation and vision outcome were compared between the two groups.Written informed consent was obtained prior to relevant examination and surgery.Results The mean effective Phaco durations were 42.56 (39.31,45.81) seconds and 78.63 (73.85,83.40) seconds in the prechop group and stop-and-chop group,with a significant difference between them (Z =-4.937,P =0.000).The eye number with different degree of best corrected visual acuity (BCVA) was significantly different between the two groups,at postoperative day 1 and day 3 (P =0.013,0.033).The number of corneal endothelial cells (CECs) 1 month after surgery was (2 026.05 ± 154.03)/mm2 in the prechop group,and the number was (1 866.50-± 117.16)/mm2 in the stop-and-chop group,with a significant difference between them (t =3.298,P=0.003).The CECs loss rate was (13.36±2.85) ％ in the prechop group,which was lower than (25.77±3.81) ％ in the stop-and-chop group (t=-6.996,P=0.000).The eye number with different degree of corneal edema was significantly decreased in the prechop group compared with the stop-and-chop group at postoperative day 1 and day 3 (P =0.001,0.002).Conclusions Compared with the stop-and-chop phaco technique,a reverse chopper-assisted pre-chopping technique can decrease the intraoperative complication,lighten the postoperative damage of CECs and accelerate visual rehabilitation in hard nucleus cataract eyes.