1.A case with neonatal Kawasaki disease.
Chinese Journal of Pediatrics 2003;41(12):960-960
Anti-Inflammatory Agents, Non-Steroidal
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therapeutic use
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Aspirin
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therapeutic use
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Coronary Vessels
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pathology
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Echocardiography, Doppler, Color
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Electrocardiography
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Erythema
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Fever
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Humans
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Hypoxia-Ischemia, Brain
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complications
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Infant, Newborn
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Male
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Mucocutaneous Lymph Node Syndrome
;
complications
;
diagnosis
;
therapy
2.Arthroscopic treatment for tuberculous synovitis of the knee: A report of 10 cases
Yayi XIA ; Hui ZHAO ; Zhengyi SUN
Chinese Journal of Minimally Invasive Surgery 2001;0(05):-
Objective To observe the therapeutic effect of arthroscopic synovectomy for tuberculous synovitis of the knee. Methods Ten patients with tuberculous synovitis received arthroscopic biopsy and synovectomy. Postoperatively, isoniazid was injected into the articular cavity, and systemic antituberculosis drugs were administrated. Results These patients received continuous passive motion (CPM) from the second postoperative day. In 9 patients, the flexion ranges of the knee were improved from 90??5? before the surgery to 120??14? after the surgery, and the extension limit of the knee, from 20??3? before the surgery to 5??1? after the surgery, with statistical significant differences ( t =6.9 and 6.3, respectively; P
3.An empirical study on the criterion-related validity of the National Medical Licensing Exami-nation
Xia ZHAO ; Wei SUN ; Xiaosong YU
Chinese Journal of Medical Education Research 2015;(1):55-58
Objective The empirical validity of the National Medical Licensing Examination (NMLE) has rarely been studied. This is one of the first studies comparing NMLE and annual assess-ment scores. This study provided the criterion-related validity evidence for the NMLE. The NMLE can be used to test the abilities and skills of physicians. Method We evaluated the test 163 residents in 12 medical school-affiliated hospitals who had finished their first year of tralning and had taken the NMLE and an annual skills assessment. We used Pearson correlations to estimate the relationship be-tween NMLE scores and annual assessment scores. Results A total of 163 residents met inclusion requirements. Correlations between NMLE scores and annual assessment scores ranged from 0.300 to 0.843. Conclusions The criterion-related validity of NMLE was high, so it can be use to evaluate the residents clinical competence indeed.
4.Twenty-seven cases of urinary retention after stroke treated by point-application combined with acupuncture.
Shi-Lin SUN ; Zhong-Ren SUN ; Zhao-Xia GUO
Chinese Acupuncture & Moxibustion 2012;32(10):933-934
Acupuncture Points
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Acupuncture Therapy
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Adult
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Aged
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Drugs, Chinese Herbal
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therapeutic use
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Female
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Humans
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Male
;
Middle Aged
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Stroke
;
complications
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Urinary Retention
;
drug therapy
;
therapy
5.Analysis of carotid and femoral arteries lesions in diabetes mellitus induced by 2D-CDUS ultrasound
Bing LI ; Baozhen ZHAO ; Xiuying SUN ; Yan SUN ; Bing XIA ;
Academic Journal of Second Military Medical University 1985;0(06):-
Objective: To evaluate 2D CDUS ultrasound in estimating lesions of carotid and femoral arteries in diabetes mellitus. Methods: Forty patients were divided into 3 groups by age. We detected their carotid and femoral arteries using two dimensional and PW Doppler ultrasonography. The lesions degree were assessed according to U B 6 classification. Results: Higher incidence and more serious degree of arteries lesions occurred in diabetes mellitus than those in control group ( P 40 years old than in group ≤40 years old in diabetes mellitus ( P
6.Acetylization of histone regulated by valproic acid sodium on the regulatory effect of cell cycle related factor
Changwen SHI ; Xia ZHAO ; Lili CA ; Jingjie SUN ; Jie LI
Chinese Journal of Microbiology and Immunology 2008;28(8):760-765
Objective To investigate the regulation on cell cycle related factor such as Cyclins and P21waf/cip1 by inhibiting histone deacetylase(HDAC)with valproic acid sodium(VPA).Methods HepG2 hep-tocellular carcinoma cells.BGC-823 gastric carcinoma cells and MCF-7 breast cancer cells were cultured with O.75-4.00 mmoL/L VPA for 48 h in vivo.and the cell cycle was analyzed by flow cytometry with PI assay.The protein and mRNA expression of Cyclin A,Cyclin D1,Cyclin E and P21waf/cip1 were analyzed by indirect immu-nofluorescence technique and RT-PCR.respectively.Results Compared with control groups,VPA at concen-trations 0.75-4.00 mmol/L exerted a significant inhibiting effect on G1 phase of HepG2,BGC-823 and MCF-7 cells(P<0.001).and the effect was dose dependent.Cyclin A was down-regulated both at mRNA and protein level in HepG2 and BGC-823 cells(P<0.001),but no difference in MCF-7 cells(P>0.05).Cyclin D1 was down-regulated both at mRNA and protein level(P<0.001)and P2lwaf/cip1 was up-regulated both at the mRNA and protein level in the three cell lines(P<0.001);Conversely,protein and mRNA expression of Cyclin E were unchanged upon treatment with VPA(P>0.05).Condusion Acetylization of histone intervened with VPA can regulate Cyclin D1 and P21waf/cip1 expressions obviously.To the expression of Cyclin A,it shows some difference according to the histogenesis and phenotypes of different carcinoma types.But there is not any obvious function on Cyclin E.Down-regulating Cychn D1 and up-regulating P21waf/cip1 may be the common target path-way in the inhibition of cell cycle G1 phase exerted by VPA.
8.Effect of chronic variable stress on forced swimming test of rats and parallel changes of hippocampus structure
Yinghong XIA ; Bing HU ; Xiaoxia SUN ; Hua ZHAO
Journal of Jilin University(Medicine Edition) 2006;0(06):-
Objective To observe the effect of chronic variable stress on the forced swimming test of rats,and investigate its preliminary mechanism.Methods First a mark was given to each Wistar rat by forced swimming test.12 Wistar rats which had similar scores were selected and divided into control group and model group averagely.The behavior changes of rats were induced in the forced swimming test by chronic stress and the plasma cortisol level was analyzed through radioimmunoassay(RIA) methods.The changes of hippocampus CA3 structure were observed with microscope.Results Compared with control group,chronic variable stress increased immobility time,reduced climbing time evidently and enhanced the weight of adrenal gland and the level of plasma cortisol(P
9.Expression of chemokine CXCL16 in murine collagen-induced arthritis and the effects on the proliferation of lymphocytes
Lin SUN ; Xiangyuan LIU ; Jinxia ZHAO ; Siliang MAN ; Xia ZHANG
Chinese Journal of Rheumatology 2011;15(3):151-154
Objective To investigate the effect of CXCL16 on the development of murine collageninduced arthritis (CIA). Methods CXCL16 mRNA of the involved synovium and serum CXCL16 protein were determined respectively by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA) in murine collagen-induced arthritis. The proliferation of lymphocytes from murine spleen and the level of RANKL mRNA, stimulated by CXCL16 at different concentrations (0,100, 200, 400, 800 ng/ml), was detected respectively by CCK-8 and RT-PCR, then the level of IL-2 and IFN-γ in culture supernatant was detected by ELISA. Comparisons between groups were tested by t test and one-way ANOVA analysis. Results The serum CXCL16 [(127± 10) vs (72±8) pg/ml, P<0.05] and synovial CXCL16 mRNA (0.214±0.007 vs 0.375±0.009, P<0.01) in CIA were all significantly higher than those in normal controls. The proliferation of CXCL16 (200, 400, 800 ng/ml) in CIA mouse lymphocytes, was significantly higher than that of CXCL16 (0 ng/ml) (0.51±0.06, 0.56±0.05, 0.55±0.04, (0.41±0.04, P<0.05). And CXCL16 on the CIA stimulated lymphocyte proliferation was significantly higher than controls on normal lymphocytes (P<0.05). Compared with blank control group, the expression of IL-2, IFN-γ and RANKL mRNA of CIA CXCL16 (400, 800 ng/ml) groups was higher significantly (P<0.01). Conclusion CXCL16 plays an important role in the development of murine CIA by activating lymphocytes.
10.Detection and clinical significance of blood D-Dimer in rheumatoid arthritis
Jinxia ZHAO ; Lin SUN ; Xia ZHANG ; Xiangyuan LIU
Chinese Journal of Rheumatology 2011;15(3):168-171
Objective To detect D-Dimer in the blood of rheumatoid arthritis (RA) patients and to investigate its clinical significance in RA. Methods Blood samples were obtained from 58 patients with RA,18 patients with systemic lupus erythematosus (SLE), 15 patients with ankylosing spondylitis, 11 patients with osteoarthritis, and 20 patients with other connective tissue diseases. The presence of thrombotic diseases was excluded in all patients. The presence of D-Dimer in the blood was examined by immunoturbidimetry. The following clinical and laboratory data were collected: disease activity index DAS28, rheumatoid factor (RF),erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Mann-Whitney U test, t-test ,Spearman correlation were used for statistical analysis. Results ① The prevalence of high level D-Dimer in RA patients was higher than that of the control group (82.6% vs 21.9%, P<0.01). The titer of D-Dimer in RA was significantly higher than that of the control group [(1.76±1.57) vs (0.32±0.25) mg/L, P<0.01]. ②DAS28 was higher in RA patients with positive D-Dimer than those with negative D-Dimer (5.4±1.0 vs 4.4±0.8,P<0.01). The values of ESR, CRP and RF in RA patients with positive D-Dimer were significantly higher than those in patients with negative D-Dimer (P<0.05). ③ There was positive correlation between D-Dimer and DAS28 (r=0.406, P<0.05), ESR (r=0.355, P<0.01), and RF (r=0.319, P<0.05). Conclusion The level of D-Dimer in the blood of RA patients is significantly higher than other rheumatic diseases, and is positively correlated with disease activities. The results indicated that the activation of coagulation-fibrinolytic systems may play a role in the pathogenesis of rheumatoid arthritis.