Acupuncture Therapy ; Adult ; Alcoholism ; therapy ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Peripheral Nervous System Diseases ; therapy

With Jianyu (LI 15), Jianliao (TE 14) and Jianzhen (SI 9) for instance, the three acupoints used to treat shoulder bi syndrome by needle knife, and through traceability and researching constant structure, the acupoint position, insertion trace, manipulation and clinical significance of needle knife medicine were discussed. Accurate position is one of the characteristics of acupoints selection of needle knife medicine. As for the acupoints selection method, the mean of body surface localization is always used. The phanerous or palpable bone processes, muscles and tendons are taken as positioning marks; pressing areas where appear sour, numb, or distensible and other sensations is considered as the principle of press positioning. So acupoints position method is the combination of observation and palpation. Different insertion methods can effectively relieve the accretive bursae synovialis, tendon, joint capsule and the compressed nerve, so that shoulder bi syndrome is relieved.
Acupuncture Points ; Acupuncture Therapy ; instrumentation ; methods ; Humans ; Needles ; Periarthritis ; therapy

This paper studies the differences of rational use of drugs policy between China and America,mainly focusing on the differences in the policy of clinical pharmacists,the research and development process of substitute for drugs,the guarantee system of medical treatment.In addition,it naturally analyzes the reasons for these kinds of differences from the view of culture and value.At last,it deeply summarizes the humanism positions and justice principles based on which the Rational Use of Drugs was drawn up from the angle of ethics.

Objective To determine the role of SCN1A gene variation in the development of familial febrile seizures (FS).Methods Clinical data were collected from 8 familial FS pedigrees, and peripheral venous blood samples were collected from the probands and other available family members. All 26 coding exons and exon-intron boundaries at least 50 bases of the human SCN1A gene were amplifled by polymerase chain reaction, the products were subsequently sequenced. To novo variation, other family members were screened for the corresponding exons. Two hundred age-matched healthy children were served as normal controls. ResultsA total of 33 variations in the SCN1A gene were identifled in these families. Of these variations, one was a missense mutation; the remaining 32 variations were previously submitted as single nucleotide polymorphisms (SNPs). A c.2650G>A heterozygous missense mutation in exon 15 of the SCN1A gene found in the proband of family 4 was inherited from his father who had seizures with fever in early childhood. The c.2650G>A mutation was absent in the 400 alleles of normal controls. To the best of our knowledge, the SCN1A c.2650G>A mutation has neither been reported in the NCBI SNP database nor in the literature to date. The c.2650G>A mutation changes a glycine at amino acid 884 in the SCN1A protein to a serine (p.Gly884Ser). Protein sequence analysis showed that the p.Gly884Ser is located at a highly conserved region between the 4th and 5th transmembrane segment of the homologous domain Ⅱ of voltage-gated sodium channel 1 subunit (DIIS4-S5). ConclusionsThe pathogenesis of familial febrile seizures was related to the SCN1A variation, the mutation outside the region of the voltage sensor (S4) and ion channel pore (S5-S6) of the voltage gated sodium channelα-subunit may be an important factor to cause mild phenotype epilepsy syndrome.

Animals ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Glomerulonephritis ; drug therapy ; pathology ; Humans ; Kidney Glomerulus ; pathology ; Phytotherapy ; Podocytes ; pathology

Objective Statistics the distribution regularity of algae literature in biomedical periodicals written in Chinese. Methods The specialized articles on algae are distributed in 285 types of Chinese periodicals with total 914 articles after retrieving Chinese Biomedical Literature Database(from 1995 to March of 2004). According to Bradford' law and Bradford zone method, three zones are divided into an approximately equal quantity of articles. The zone division is based on the quantity of articles in the periodicals and a digressive sequence as well. Results There are 14 periodicals in the first zone with 308 articles published, which are 4.91% of the total periodicals and 33.7% of the total articles. It could provide the 1/3 information and it is the Core Journals. Conclusion The articles published in Chinese Journal of Marine Drugs are the most, which reaches 90 and occupies 9.8% of the total; therefore, it shall be given priority when alga articles are selected. The scientific comments on periodicals can direct researchers on algae to attain necessary information.

Flavonoid Pilulae from Gegen were prepared by melting method. Using PEG 4000 and PEG 6000 as carrier. Serious of studies on the in yitro release kinetics were carried out.PEG4000 ; PEG6000 ratio had no effect on the release kinetics. PEG 4000: flavonoids ratio had an evident effect on the release properties of the pilulae, the higher the ratio,the faster the release rate. But when the PEG 4000, flavonoids ratio exceeded 10: 1, a reverse effect could be seen. Compared with "Gegen flavonoids" tablets, "Yufengingxin" tablets(release half time, T50= 94.79min), the pilulae gave a much fast release characteristic (T50 = 11. 56min).

Objective To investigate the easement degree of pain after the treatment of low back pain patients in 6 months after the operation.Methods To treat lumbar degenerative osteoarthritis (21cases),lumbar disc herniation(31 cases),Lumbar spinal stenosis assompanied with lumbar disc herniation(1 cases) with percutaneous radiofrequency-ablation,compare the JOA,VAS,Oswestry score of the patients before and at the just after operation,2 weeks,6weeks,3 months,6 months after operation.Results The JOA score of patients after operation rise obviously than that of patients before operation,and VAS and Oswestry score reduce obviously,they all have statiscal significance(P ＜ 0.05).Conclusion The pain of patients who suffered from discogenic low back pain,lumbar disc herniation is relieved by percutaneous radiofrequency-ablation,the quality of patients'life is heightened,all of above indicate that the treatment is an effective method for discogenic low back pain,lumber disc herniation.

Objective To determine the clinical effect of Iodized Lecithin Capsules in the treatment of vitre-ous hemorrhage.Methods 102 patients ( 102 eyes ) with vitreous hemorrhage were divide into Group A ( treatment group) and Group B ( control group);the treatment for Group A with 52 patients (52 eyes) is taken Iodized Lecithin Capsules orally;for Group B with 50 patients (50 eyes),it was the prolonium iodide through intramuscular injection. The course of treatment for both Group A and B was 3 months and all the patients in the two groups receive systemic diseases treatment and etiological treatment at the same time.The clinical effects of both groups will be compared. Results The effective rate for Group A was 82.7% whereas the figure for Group B was 64.0%.The differences between the two groups had statistical significance(χ2 =4.58,P <0.05).Conclusion By taking Iodized Lecithin Capsules orally is a very effective way to treat vitreous hemorrhage without obvious side effects.The treatment is safe and effective.

Drug research involves scientific discovery, technological inventions and product development. This multiple dimensional effort embodies both high risk and high reward and is considered one of the most complicated human activities. Prior to the initiation of a program, an in-depth analysis of "what to do" and "how to do it" must be conducted. On the macro level, market prospects, capital required, risk assessment, necessary human resources, etc. need to be evaluated critically. For execution, drug candidates need to be optimized in multiple properties such as potency, selectivity, pharmacokinetics, safety, formulation, etc., all with the constraint of finite amount of time and resources, to maximize the probability of success in clinical development. Drug discovery is enormously complicated, both in terms of technological innovation and organizing capital and other resources. A deep understanding of the complexity of drug research and our competitive edge is critical for success. Our unique government-enterprise-academia system represents a distinct advantage. As a new player, we have not heavily invested in any particular discovery paradigm, which allows us to select the optimal approach with little organizational burden. Virtue R&D model using CROs has gained momentum lately and China is a global leader in CRO market. Essentially all technological support for drug discovery can be found in China, which greatly enables domestic R&D efforts. The information technology revolution ensures the globalization of drug discovery knowledge, which has bridged much of the gap between China and the developed countries. The blockbuster model and the target-centric drug discovery paradigm have overlooked the research in several important fields such as injectable drugs, orphan drugs, and following high quality therapeutic leads, etc. Prejudice against covalent ligands, prodrugs, nondrug-like ligands can also be taken advantage of to find novel medicines. This article will discuss the current challenges and future opportunities for drug innovation in China.