OBJECTIVE:To optimize the formulation parameters of poly1,3-bis(p-carboxyphenoxy) propane-sebacic acid (P(CPP∶SA)) microsphere and evaluate its drug release performance in vitro. METHODS: The paclitaxel microspheres were prepared by single emulsion method,and the effects of the factors such as the stirring speed (A),P(CPP∶SA) concentration (B),emulsifier polyvinyl alcohol (PVA) concentration (C) on encapsulation efficiency were evaluated by orthogonal test. The surface morphology of the prepared microsphere was observed and its drug release performance in vitro was evaluated. RESULTS: The optimal formulation of the microsphere obtained was as follows: A was 4 000 r?min-1,B was 80 mg?mL-1 and C was 1%,respectively. The morphology of microspheres was round and intact. The encapsulation efficiency of paclitaxel was up to above 90%. The sustained release duration was 30 days with an accumulative release rate of over 80%. CONCLUSION: Paclitaxel microspheres prepared by optimal formula display a high encapsulation efficiency and satisfactory sustained-release pattern.

Hospital Information System(HIS) contributes a lot to the management of the hospital with the personnel flow,the material flow,the fund flow and the information flow well-regulated.The construction of HIS has to be based on general scheme,and then the sub-systems are established separately,at last all sub-systems are integrated to form a system,that is HIS,to realize the modernization of the hospital management.

Acupuncture Therapy ; Female ; Humans ; Middle Aged ; Neuromyelitis Optica ; physiopathology ; therapy ; Vision, Ocular

In recent years,scientific reports say that ApoE genotypes not only influence lipid metabolism but also affect bone metabolism through vitamin K. Primary osteoporosis is mainly regulated by genes and the interaction of genes and environmental factors also affects primary osteoporosis. This review focused on the mechanism of the influence of ApoE gene on bone mineral density and interaction of ApoE gene and environment factors in the determination of primary osteoporosis.

This study explores the association between physician-patient communication and healthcare service quality,and relevant factors.The physician-patient communication belongs to medical behaviors,and plays a key role in the improvement of physician-patient relationship and the overall healthcare service quality.The consults of physician-patient communication were affected by many factors including physicians' attitude,and usage of words and behaviors,in which the positive attitude and behaviors are key solution to the improvement physician-patient relationship.Therefore the urgent matters are to strengthen standardized management of physician-patient communication,and set up related regulations and effective measure.

Acupuncture Therapy ; Adult ; Alcoholism ; therapy ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Peripheral Nervous System Diseases ; therapy

Objective: To observe the influence of circumferential pulmonary vein isolation (CPVI) on P-wave polarity and amplitude and to investigate whether the changes of P-wave are associated with patient outcomes after initial CPVI. Methods Fifty patients with paroxysmal atrial fibrillation (AF) underwent CPVI. For each patient, electrocardiograph (ECG) recordings were taken before and 7 days after ablation. The P-wave polarities and amplitudes were analyzed. Successful CPVI was defined as freedom of symptomatic and asymptomatic AF at the end of two consecutive follow-ups. Results: The amplitude of positive P-wave was significantly decreased in the leads of I, II, III, aVF, V5, and V6 after ablation (P<0.05). The amplitude of negative P-wave was significantly decreased in the leads of aVR and aVF after ablation (P<0.05). The total amplitude of P-wave was significantly decreased in the leads of I, II, aVR, V5 and V6 after ablation (P<0.05). The negative P-wave in the lead of III and the positive P-wave in the lead of aVL were increased after ablation. The amplitudes of negative, positive and total P-waves before and after ablation were not significantly different between successful CPVI (n=39) and failure CPVI (n=11) groups. Conclusion: CPVI can result in noticeable reduction of P-wave amplitude in several leads of ECG, indicating the reduction of left atrial electric capacity. The changes of P-wave polarity indicate a P-wave vector shift. The reduction degree of P-wave amplitude has no predictive value for the success or failure of CPVI.

Objective: To characterize the anatomic morphology of pulmonary vein ostium by 2-D and 3-D computed tomography angiography. Methods: Thirty patients with paroxysmal/persistent atrial fibrillation (AF) undergoing computed tomography angiography before catheter ablation of AF were analyzed for the anatomic morphology of pulmonary vein ostium in 2-D and 3-D manner. Results: The diameter in axial, coronal and sagittal views of diameters of the pulmonary veins ostium (PVs) were (16.90±4.79) mm, (21.37±4.23) mm, (22.41±3.96) mm in the left superior pulmonary vein(LSPV), (13.50±3.99) mm, (15.84±3.22) mm, (16.82±3.63) mm in the left inferior pulmonary vein(LIPV),(17.77±4.69) mm, (19.11±4.10) mm, (19.71±4.33) mm in the right superior pulmonary vein(RSPV),and (15.33±3.88) mm, (16.20±4.00) mm, (17.10± 4.24) mm in the right inferior pulmonary vein(RIPV). The maximal and minimal diameters (dmax and dmin) of PVs in 3-D view were (24.30±4.54) mm, (17.76±4.24) mm in LSPV, (19.10±4.45) mm, (12.27±3.52) mm in LIPV, (22.99±5.04) mm, (16.19±4.87) mm in RSPV, and (18.63±4.60) mm, (14.46±3.48) mm in RIPV. There is difference of diameters between SPVs and IPVs (P<0.01) in two-dimensional and three-dimensional view except for RIPV. Conclusion: CT imaging can present precise 3-D reconstruction of the pulmonary vein ostium, allowing for understanding the details before catheter ablation. There is great variance in the dimension of the pulmonary vein ostium among individuals, which should be taken into consideration before operation.

Objective: To summarize our initial experience on three-dimensional electroanatomic mapping with Carto-Merge, so as to provide evidence for guiding catheter ablation of atrial fibrillation (AF). Methods: Fifteen patients with paroxysmal/persistent AF (13 paroxysmal and 2 persistent), who were to receive catheter ablation, were analyzed by CARTO-MERGE, which combines computed tomography (CT) angiography, picture merging, guiding ablation, etc. Results: There were 103±13 mapping points before ablation, with 66±15 in the left ablation circle and 58±20 in the right. The distance between points and surface was (1.8 ± 0.2) mm in the merged images. Operation time was (305 ± 45) min and the X-ray exposure time was (52 ± 18) min. Isolation of pulmonary veins potential was achieved in all patients and there was no complication during the operation. Conclusion: Three-dimensional CT images is very close to the the real anatomy of left atrium and pulmonary veins. Carto-merge technique can overcome some shortcomings of Carto electroanatomic mapping pictures, which can improve the successful rate of operation and reduce complication.

Objective: To observe the electrophysiological effects of ibutilide on the normal cardiac conduction system and accessory pathways (AP) of patients with accessory pathways mediated reentrant tachycardia (AVRT) and to assess the safety of ibutilide in electrophysiology study (EPS) and radiofrequency catheter ablation (RFCA). Methods: Twenty-one patients with AVRT undergoing EPS received intravenous ibutilide (1 mg). Electrophysiological parameters, including P-A interval, A-H interval, H-V interval, QRS complex width, QT interval, paced QT interval, right atrial effective refractory period (RA ERP), right ventricular ERP (RV ERP)q atrioventricular node ERP (AVN ERP), AVN block cycle length (AVN BCD, antegrade AP ERP and retrograde AP ERP 9 were observed before and instantly, 15 min, and 30 min after injection of ibutilide. Results: There was no statistical difference in the P-A interval, A-H interval, H-V interval and QRS complex width before and after ibutilide injection(P>0.05). After injection of ibutilide, the QTc, QT intervals, the RA ERP, RV ERP, and AVN BCL were all significantly prolonged (P<0.05). The antegrade and retrograde ERP of AP were also increased (P<0.05), with no loss of antegrade and retrograde function of AP. All patients underwent successful ablation and Torsade de pointes (Tdp) and no other adverse effects were noticed. Conclusion: Ibutilide has no effect on the conductivity of normal cardiac conduction system. Routine dosage of ibutilide can prolong ERP of AP but does not block the conductivity, with no influence on electrophysiology study and radiofrequency catheter ablation. Ibutilide has no adverse effect on patients with AVRT.