1.COL3A1、COL1A2 Genes and Intracranial Aneurysms
Tao HUA ; Ji-Zong ZHAO ;
International Journal of Cerebrovascular Diseases 2006;0(11):-
Tae formation,development and rupture of intracranial aneurysms result from the interaction of genetic and environmental factors.The genetic mode may be nonclassical Mendelian inheritance for most patients with intracranial aneurysms.Studies have shown that COL3A1 and COLI A2 genes of the coded main extracellular matrix proteins in the arterial walls are closely associated with intracranial aneurysms.
6.Relationship between Characteristic of Symptoms and Executive Functions in Children with Tourette′s Syndrome
jian-hua, ZHAO ; zuo-ming, CHEN ; wei-dong, JI
Journal of Applied Clinical Pediatrics 2006;0(19):-
Objective To investigate the correlation between executive function(EF) and characteristic of symptom in children with Tourette′s syndrome(TS).Methods EF were measured with Wisconsin Card Sorting Test(WCST) in 53 patients with TS,and symptom characteristics were evaluated with Achenbach Child Behavior Checklist(CBCL) and Yale Global Tic Severity Scale(YGTSS).Results Compared with healthy control,TS had poor executive performances significantly in WCST(all P
8.Flavone C-glycosides from seeds of Ziziphus jujuba var. spinosa.
Ke-xian CHEN ; Li-mei ZHAO ; Chang-jiu JI ; Ning-hua TAN
China Journal of Chinese Materia Medica 2015;40(8):1503-1507
Five flavone C-glycosides were isolated from the methanol extract of the degrease seeds of Ziziphus jujuba var. spinosa though various column chromatography methods including silica gel, MPLC, and HPLC. The structures were elucidated as 6"-feruloyl- 6'''-vanillylspinosin(1), 6",6'"-diferuloylspinosin(2), spinosin(3), swertisin(4) and isoswertisin(5) based on the NMR and MS spectral data. 1 is a new compound.
Drugs, Chinese Herbal
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chemistry
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isolation & purification
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Flavones
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chemistry
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isolation & purification
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Glycosides
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chemistry
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isolation & purification
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Seeds
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chemistry
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Ziziphus
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chemistry
9.A mouse model of bacterial vaginosis established by infecting estrogen-treated mice with Prevotella bivia
Hongmei JIAO ; Dan ZHAO ; Hongju CHEN ; Hua YAN ; Mingchun JI ; Guocai LI
Chinese Journal of Microbiology and Immunology 2016;36(6):423-426
Objective To establish a mouse model of bacterial vaginosis ( BV) by infecting estro-gen-treated mice with Prevotella bivia ( P. bivia) . Methods The mice were intraperitoneally injected with beta-estradiol 17 valerate which was suspended in sesame oil and then inoculated with different doses of P. bivia strains at the logarithmic phase. Samples of vaginal flushing fluid were collected at different time points after inoculation and used for the isolation of P. bivia strains and the detection of sialidase activities. Altogether 30 mice treated with estrogen and high dose of P. bivia were killed on days 2, 7 and 21 (n=10). Samples of cornua uteri, bladder and kidney were collected from those mice for P. bivia strains isolation. Re-sults Injection the estrogen-treated mice with P. bivia via vagina could cause the P. bivia infection for more than 14 days. The numbers of P. bivia strains isolated on day 21 decreased significantly. Enhanced sialidase activities and clue cells were observed in vaginal secretions of mice with P. bivia infection. Injection of mice with the high dose of P. bivia could spread the infection to cornua uteri. Conclusion Estrogen-treated mice could be used as an animal model for researches on BV.
10.Relative bioavailablity of cefaclor effervescent tabletsin human volunteers
Fu-Rong QIU ; Jin-Mei JI ; Bo CHENG ; Zhao-Hong ZENG ; Hua SUN ; Guo-Guang MAO ;
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(02):-
Aim To study relative bioavailablity of cefaclor effervescent tablets in healthy volunteers. Methods According to the crossover design, A volunteers were each orally given a single does of the 0.75 g cefaclor effervescent tablets and cefaclor capsules with an interval of 5 days between the two formulations.The plasma concentrations of the drug were determined by RP-HPLC.Pharmacokinetic parameters were obtained by ATPK programe,and calculated on the basis of open single compartment model.Results After a single oral dose, the peak levels in plasma averaged Cmax(31.27?5.81)?g?ml-1 and(30.56?5.25) ?g?ml-1 at (0.58?0.12)h and(0.73?0.17)h and AUC0~4(35.48?4.65) ?g?h?ml-1 and (35.89?2.90) ?g?h?ml-1 for tablet and capsule,respectively. Conclusion The result shows that two formulations are bioequivalence.