Objective To observe the effect of environmental factors change on the hemorheology of the rabbit with myocardial ischemia.Methods The rabbits were divided into six groups,the group of myocardial ischemia(myocardial ischemia operation),the group of myocardial ischemia with hypoxia(volume fraction of oxygen of 91.5% nitrogen and 8.5% oxygen) and high temperature [(42?2)℃],the group of myocardial ischemia with hypoxia(volume of fraction of oxygen of 91.5% nitrogen and 8.5% oxygen),the group of myocardial ischemia with hypoxia(volume of fraction of oxygen of 91.5% nitrogen and 8.5% oxygen) and high temperature[(42?2)℃] and hunger(forbid water and fast in 24 h),the group of myocardial ischemia with hunger,control group,10 in each.After 30 minutes of treatment,the indexes of the hemorheology were determined.Results The changed environmental factors,hypoxia,high temperature,hunger,presented an increasing effect on the blood viscosity,plasma viscosity,blood high shear reduced viscosity,blood low shear reduced viscosity and equation K value of ESR(P

Objective To explore the environmental factors change on the plasma endothelin(ET) and nitric oxide(NO) in rabbits exposed to a complex environment:high temperature,hunger,and so on.Methods Ninety China rabbits were randomly divided into myocardial ischemia group,myocardial ischemia and hypoxia and high temperature group,myocardial ischemia and hypoxia group,myocardial ischemia and hunger group,myocardial ischemia and hypoxia and high temperature and hunger group,hunger group,hypoxia group,high temperatures group,control group,ten rabbits in each group.The animal myocardial ischemia was caused by fulgurating the left anterior descending branch artery in the heart.The animal hypoxia was caused by breathing in 8.5% nitrogen oxygen atmosphere(nitrogen content was 91.5%,oxygen content was 8.5%).The animals in the high temperature group were put into a high temperature [(42?2)℃] environment.The animals in the hunger group were treated with fasting and water deprivation for 24 h.Every animal has been taken in above-mentioned experiment environment for 30 min.Blood from jugular veins collected,and the contents of plasma ET and NO were determine.Results Compared with control group,except the hunger group and high temperature group,ET levels in the others six group were significantly increased(P

Objective To study the effects of acute low temperature and hypoxia on serum SOD and MDA of myocardial ischemia rabbit. Methods 24 rabbits were randomly divided into 3 groups, such as normally low tamperature and hypoxia group, myocardial ischemia normal temporature and normal oxygen group and myocardial ischemia low temporature and hypoxia group. Put myocardial ischemia rabbits into the condition in which low temperature(-10?2) ℃ and hypoxia (oxygen content 8.5% ) existed, superoxide dismutase (SOD) activity and malondialdehyde (MDA) contents were measured after an hour. Results Serum SOD activity were decreased significantly in acute low temperature and hypoxia compared with normal temperature and normal oxygen pressure (P

Neuroendoerine carcinoma of paranasal sinuses are rare malignant tumors, neuroendocrine carcinomas cases with the lesions at different sites differ in the prognosis, The key to improving the survival rate of the disease is early accurate diagnosis and complete surgical removal of the lesions.
Adult ; Carcinoma, Neuroendocrine ; Follow-Up Studies ; Humans ; Male ; Paranasal Sinus Neoplasms ; Sphenoid Sinus

Mucus secreted mainly by epithelial goblet cells and submucosal glands covering the respiratory tract plays an important role in the protection from external aggressions, such as solid particles, pathogens and chemical agents by mucociliary clearance. The viscoelastic properties of mucus are mainly determined by the presence of extensively-glycosylated high molecular weight mucins. A lot of factors influence the expression and secretion of mucins in airway, lead to mucus overproduction, which is a distinguishing feature of chronic obstructive pulmonary disease (COPD) and causes disruption of the mucociliary clearance function, resulting in airway block, chronic infection and death.

In recent years,Department of Pharmaceutical at Hunan Normal University,taking advantage of the resources of comprehensive university and taking the new model of credit as the turning point,has carried out profitable exploration and practice in the reform of undergraduate teaching and has put forward some ideas to deepen pharmaceutical teaching reforms.

Objective To explore the effects of alcohol on NO concentration in plasma and activity of ATP enzyme in erythrocytes of rabbits. Methods 32 rabbits were divided into groups and treated with alcohol, injected intravenously, at the doses of 0.5 g/kg, 1.0 g/kg and 1.5 g/kg, 15 minutes after treatment, the blood samples were collected and NO concentration in plasma, activity of ATP enzyme in erythrocytes were determined. Results NO concentration in plasma of rabbits significantly decreased in 0.5 g/kg and 1.0 g/kg groups, but increased in 1.5 g/kg group (P

Objective To examine the relationship between hematocrit and risk of long term mortality among patients with acute myocardial infarction. Methods A total of 274 patients with acute myocardial infarction were recruited and divided into two groups by death after long term follow-up, the relationship between hematocrit and mortality was evaluated through the methods of independent t-test,chi-square test and multivariate regression analysis. Results The mean age was 69. 79 ± 7.45 years, with 73. 0% of male. The average of followup was 44. 4± 10. 7 months, with mortality of 38.7% . Comparison of baseline data showed that NYHA classification, smoking history, hemoglobin, hematocrit, mean red cell volume, glomerular filtration rate, ejection fraction,left ventricular diastolic diameter and right ventricular diameter was significantly different between the two groups( Ps ＜ 0. 05), Multivariable logistic analysis showed that hematocrit ,glomerular filtration rate, ejection fraction and smoking history were independently predicted factors, with OR of 0. 904 (95% CI: 0. 832 - 0. 982,P =0. 016) ,0. 983 (95% CI: 0. 969 -0. 996,P =0. 014) ,0. 932 (95% CI: 0. 887 -0. 979,P =0. 005) and 3. 230 (95% CI: 1.468 - 7. 106, P = 0. 004), respectively. The power of hematocrit to predict mortality was examined by ROC curves, the area under the curve was 0. 669(P ＜ 0. 001,95% CI: 0. 603 - 0. 736) Conclusion Hematocrit is a significant independent predictor for long term death among patients with acute myocardial infarction.

In order to make good use of laboratory opening,the way,method together with the effect of laboratory opening in our college were analyzed and discussed in this paper. The perfect practice effect shows that laboratory opening plays an important role in cultivation for independent research abilities and scientific innovative abilities of undergraduates.