Objective To develop a method for nou-invasive risk model that can be used in health management system and primary healthcare centers. Methods Based on systematic phenotype measurement and modified superviser-based machine learning, an applicable and low-cost method for non-invasive disease risk prediction model was developed. Invasive risk assessment model for Chinese isehemic cardiovascular diseases (ICVD) was used as a supervised standard reference to provide evidence based non-invasive model with skin resistance on 24 acupeints. Results A total of 4606 cases from a physical examination system were collected to develop the model. For those reasonable evaluation indeies, the coincidence of non-invasive with invasive risk prediction model was > 90% on average level. Conclusions This method could be used to develop non-invasive risk assessment model for the common diseases.

Taking Liaoning Medical University as an example , the paper introduces the Problem -based learning ( PBL) teaching mode into the teaching of the medical information retrieval course for graduate students .It introduces the overall design and arrangement of PBL teaching and the implementation process of teaching .By questionnaire surveys , analysis of individual retrieval reports and assess-ment of PBL teaching effects , it points out existing problems and proposes several measures for optimizing PBL teaching .

Primary hepatic carcinoma (PHC) is one of the most common cancers worldwide and is the leading cause of death in China. Multidisciplinary treatment is widely accepted as the way to improve the prognosis of PHC, and non-surgical therapy now plays a more and more important role. The purpose of this article is to review the current status and progress of non-surgical treatments of PHC, such as TACE, local ablation, radiotherapy and systemic therapy.

BACKGROUND:With the development of tissue engineering technology, repairing large-area bone defects using tissue-engineered bone has become a hot spot.
OBJECTIVE:To introduce the bone tissue engineering seed cel s, cytokines, as wel as the characteristics of scaffold materials and their vascularization.
METHODS:With the key words of“bone tissue engineering, scaffold, vascularization”in Chinese and in English, respectively, a computer-based search of articles published from January 2000 to January 2012 was performed in CNKI and PubMed databases. Articles with the summary of bone tissue engineering, bone tissue engineering scaffolds and scaffold vascularization were included.
RESULTS AND CONCLUSION:The selection of seed cel s, application of cytokines, scaffold material performance and degree of vascularization in bone tissue engineering has an important influence on the repair of bone injuries. Appropriate seed cel s is the study foundation in bone tissue engineering, cytokines serve as catalysts, and scaffold materials with good three-dimensional structure can promote cel growth and proliferation, tissue ingrowth, osteogenesis and vascularization. Each scaffold has its own inadequacies, so the combination of a variety of materials can reach a combined effect to meet the clinical demand. In addition, it is important to actively seek new material preparation technology and improve the existing methods, in order to create a more excel ent scaffold. But the vascularization is stil a major test for bone tissue engineering. Current methods to promote vascularization of tissue-engineered bone have some defects. For examples, the use of growth factors to promote vascularization can lead to disease progression in patients with metabolic abnormalities during;microsurgical techniques for tissue engineering bone vascularization are easy to cause trauma and deformity at other parts, which is not conducive to the patient’s physical rehabilitation.

Objective To explore the efficacy and side effect of CAG (G-CSF, aclarubicin and cytarabine) priming chemotherapy for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Methods 54 patients with AML at diagnosis and relapse or MDS were'enrolled for the initial treatment with CAG regimen. Patients who have achieved complete remission (CR) were treated with various regimens. Results The total effective rate was 72.2 %, complete remission rate was 48.1% and partial remission rate was 24.1%. The incidence of granulocyte deficiency was 40.7 %(22/54). The severe infection rate was 24.1%(13/54). One case died of function damage in liver. The study includes 36 patients below 60 years, 18 patients above 60 years, and overall effective cases are 28 (77.8 %), 11 (61.1%),respectively. There was significant difference (P ＜0.05). Conclusion CAG regimen is effective and well tolerated in remission for AML and MDS-RAEB.

Objective:To observe the efficacy of acupuncture plus tuina therapy for insomnia.
Methods:Totally 100 eligible patients were randomized into a treatment group (n=51) and a control group (n=49) by using the random number table. The treatment group was intervened by acupuncture at Baihui (GV 20), Fengchi (GB 20), Wangu (GB 12), Shenting (GV 24), Anmian [Extra, locates at the midpoint between Yiming (EX-HN 14) and Fengchi (GB 20)], and Neiguan (PC 6) plus tuina treatment; the control group was intervened by acupuncture alone. For both groups, the treatment was given once a day, 10 sessions as a treatment course, and the efficacies were evaluated and compared after 3 treatment courses.
Results:Of the 51 subjects in the treatment group, 46 cases completed 3 treatment courses, and 17 cases were cured, 18 cases showed marked efficacy, 7 cases were improved, 4 cases had invalid result, and the total effective rate was 91.3%. Of the 49 subjects in the control group, 46 cases completed 3 treatment courses, and 8 cases were cured, 12 cases showed marked efficacy, 14 cases were improved, 12 cases had invalid result, and the total effective rate was 73.9%. The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05).
Conclusion:Acupuncture plus tuina can calm the mind and activate meridian qi in treating insomnia, and it can produce a more significant efficacy than pure acupuncture treatment.

The effects of zymosan-activated plasma(ZAP) on the lipid peroxides(LPO) content, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in lung lymph and their relationship to lung injury were studied in control (with normal leukocyte count) and leukopenic goats. In the control goats, after ZAP infusion, LPO production elevated, that was coincided with the increase of lung lymph flow (QL), and the clearence rate of lung lymph protein (LLPC). SOD activity was also elevated, but GSHpx activity was inhibited. In leukopenic goats, ZAP challenge caused an increase in LPO production, but its content was lower than that in control goats. No marked change was observed in QL and LLPC. The results suggest that: (1) Leukocytes and oxygen free radicals are involved in the pathogenesis of lung injury due to ZAP infusion; (2) Leukocytes play an important role in producing oxygen free radicals.

Probucol is a hypolipidemic agent with a unique pharm ac odynamic and clinical profile. It has a significant antiatherosclerogenic role a lthough it causes a marked decrease in serum high-density lipoprotein (HDL)-ch olesterol levels. The metabolism of HDL in vivois unclear. Some preliminary investigations suggest a beneficial effect in enhancing reverse cholesterol tra nsport which contributes to antiatherosclerosis of probucol. This paper reviews the mechanism of HDL-lowering effects of probucol.

Congenital cataract is responsible for approximately one tenth of childhood blindness worldwide.Generally,cataract includes three inheriting types:autosomal dominant,autosomal recessive or X-linked.The identified genes so far for hereditary cataracts in both human and animal model mainly include encoding structural lens protein,gap junction protein,membrane protein and regulatory protein involved in lens development.Crystallins are the major structural protein of the lens.Mutation in the crystallin genes can result in lens opacity.Understanding of the mechanism of hereditary cataract may also be helpful for us to understand the involvement of environmental and nutritional factors in the process of lens opacification.The function of the crystallins proteins,the mutations in crystallin genes and associated phenotypes are summarized.

Therapies for uveitis include drug treatment and surgery.Medical therapies including proper administration of corticos- teroids,immunosuppressive drugs,nonsteroidal anti-inflammtion drugs and anti-infective drugs are important in management of the in- traocular inflammation and decreasing the risk of complications,furthermore,are the basis for surgical treatment of uveitis.