Objective To investiGate the constituent ratio of etioloGy,complications and tumor occurrence of maintenance hemodialysis patients. Methods Obseved the patients with maintenance hemodialysis in ZhonGshan Hospital Affiliated to Dalian University in 20l3. The patientsˊ aGe,Gender, protopathy,and other basic information includinG statistics complication and tumor occurrence rate were surveyed. Results There was same ratio of male and female in 222 cases. The primary disease of diabetic nephropathy accounted for 30. 2%( 67 cases ),hypeertensive nephropathy 2l. 2%( 47 cases ),chronic Glomerulonephritis l8. 0%(40 cases),polycystic kidney 6. 8%(l5 cases),obstructiverenal injury accounted for 5. 4%(l2 cases)and other diseases. HemoGlobin of 73 cases(32. 0%)reached the tarGet value(lll G/L) . There was 55. 2% of patients ( l23 cases ) experienced calcium and phosphorus metabolism disorder. Parathyroid hormone levels of 47. 4% patients( l47 cases ) were hiGher than normal. The tumor incidence was 7. 6%( l7/222 ). Conclusion The major primary disease of the patients with maintenance hemodialysis are diabetic nephropathy,hypertension nephropathy and chronic Glomerulonephritis. The level of hemoGlobin,calcium and phosphorus metabolism disorder and parathyroid hormone are low. There is hiGh incidence of tumor.

OBJECTIVE:To reflect the representative problems existing in the medication safety of public from the side,and provide reference for conducting the following public survey in a large area. METHODS:Questionnaires were used to investigate the knowledge of drug and medication habits of teachers in a senior high school in Beijing,and the received data was statistically analyzed. RESULTS:Totally 88 questionnaires were issued in this investigation,84 effective questionnaires were acquired,with ef-fective recovery of 95.45%. A few teachers had blind faith in intravenous infusion and preferred using antibiotics without doctor's di-agnosis when they caught a cold and fever;48.81%of the respondents barely understood or only partly understood the drug instruc-tions;34.52% didn't know that more serious adverse reactions induce by intravenous infusion were more serious than by oral treat-ment;46.43% rarely checked the period of validity of reserved drugs at home;38.10% didn’t following directions when taking drugs;80.95% had never received the education of medication safety,and 21.43% of them had no intention to accept this educa-tion;when taking drugs for a long time,79.76% of them didn’t do regular examinations of blood routine,renal and liver function tests. CONCLUSIONS:The knowledge of drug use of the respondents in the school is poor,there are many misunderstandings ex-isted in the medication habit,which prompts hidden trouble also exists in medication safety,and reflects hidden trouble commonly exists in medication safety for public from the side.

BACKGROUND: Dentin particles, tricalcium phosphate/collagen protein composites and Bio-oss particles can repair jaw defects, but the excellent osteogenic effect is not clear. OBJECTIVE: To compare osteogenic effects of three different bone graft materials on mandibular defects in beagle dogs. METHODS: Eight 1-year-old beagles were selected. A boxed bone defect area of 10 mm × 8 mm × 2 mm was prepared at the bilateral mandibular external oblique line and randomly divided into four groups with four bone defect models in each group. Undemineralized dentin particles were implanted in group A; tricalcium phosphate/ collagen protein composite materials were implanted in group B; Bio-oss particles were implanted in group C; and group D was used as blank control. Three months after transplantation, the samples were taken for histological observation. The experimental animals were approved by the Ethics Committee of the Experimental Animal Center of Dalian Medical University. RESULTS AND CONCLUSION: (1) In group A, dentin particles were slightly absorbed, surrounded by new bone tissue; new bone trabeculae and capillaries could be seen, and a large number of fibrous connective tissue surrounded dentin particles in the central area of bone graft. In group B, a small number of new bone trabeculae and osteoblasts could be seen; a large number of powdered β-tricalcium phosphate particles and a small amount of inflammatory cells could be seen in the fibrous connective tissue; and some β-tricalcium phosphate particles were surrounded by new bone tissue. Bone marrow cavity could be seen in the new bone. In group C, some Bio-oss particles were surrounded by new bone tissue; some Bio-oss particles were wrapped by surrounding fibrous connective tissue, and fibers, particles and new bone were intertwined. There was no new bone formation in group D, and many capillaries could be seen in a large number of fibrous connective tissue. (2) The rate of new bone formation in groups A, B and C was higher than that in group D (P < 0.05); the rate in groups A and C was higher than that in group B (P < 0.05). (3) The results show that all the three kinds of bone graft materials can promote the formation of new bone. The short-term osteogenic effects of undecalcified xenogeneic dentin particles and Bio-oss particles are better than tricalcium phosphate/collagen protein composites, but the long-term effects need to be further observed.

Quantitative analysis on diffusion tensor imaging is prerequisite. The arithmetic of statistical analysis was reviewed in this article via analyzing the arithmetic of quantitative parameters and fiber track on diffusion tensor imaging.

ObjectiveTo study the anti-cancer effects and mechanism of Gexia-Zhuyu decoction combined with cyclophosphamide on EAC liver cancer mice.MethodsChoose EAC liver cancer mice cell lines and production of animal models of tumor.The mice were completely randomized into blank group,model group,the Chinese medicine group,CTX group,Chinese medicine and CTX group.The blank group and model group were given normal saline 0.4 ml/d; traditional Chinese medicine group was administrated with Gexia-Zhuyu decoction (11 g/kg body weight ) 0.4 ml/d gavage; CTX group was given intraperitoneal injection of 2 mg/ml of cyclophosphamide 0.4 ml/d; and traditional Chinese medicine and CTX group was given Gexia Zhuyu decoction 0.4 ml/d orally and CTX intraperitoneal injection of 0.4 ml/d.Ten days after the administration,the body weight of mice and the general condition were tested,and morphology was observed under the light microscope electron microscope mesenchymal tumor angiogenesis situation.Results Gexia-Zhuyu decoction combined with cyclophosphamide in mice could improve appetite,gain weight,and greatly reduce the tumor stroma in the number of capillaries under the electron microscope together with significant pathological morphological changes.Conclusion Gexia-Zhuyu decoction combined with cyclophosphamide had anti-cancer effects which can improve the quality of life and inhibit the growth of tumor in interstitial capillaries.

OBJECTIVE To observe the efficacy of specific immunotherapy (SIT) with Alutard and NHD in children with allergic rhinitis due to different level of skin prick test (SPT) with dermatophagoides farinae (DF) and dermatophagoides pteronyssinus (DP). METHODS A total of 178 children with persistent allergic rhinitis were included in this study. Their age ranged from 6 to 12 years. They were divided into 3 groups according to level of SPT. Group 1: The level of skin index (SI) of DF is greater than that of DP, Group 2: The level of SI of DF is equal to that of DP and Group 3: The level of SI of DF is less than that of DP. The children in each group were randomly divided into 2 subgroups: Alutard group and NHD group. The children were given SIT with Alutard or NHD for one year. Symptom and medication scores were recorded and analyzed. RESULTS After receiving therapy for 3 months and 6 months, symptom and medication scores of the Group 1 and 2 in the NHD group were lower than those in the Alutard group (P<0.05); Symptoms and medication scores of the Group 3 in the Alutard group were lower than those in the NHD group (P<0.05). After receiving therapy for 9 and 12 months, the symptom and medication scores of the NHD and Alutard group in all the three groups showed no statistical difference (P>0.05). CONCLUSION The efficacy of SIT with Alutard and NHD is different in children with allergic rhinitis with different levels of SPT due to DF and DP after 3 and 6 months, but is similar after 9 and 12 months. SIT with Alutard and NHD is effective in treating children with allergic rhinitis.

Objective To explore the associations between polymorphisms in CYP24A1 gene and the risk and prognosis of colorectal cancer ( CRC) .Methods A case-control study consisting of 528 CRC patients and 605 cancer free controls and a follow up study with 317 cases were conducted to explore the associations be-tween two polymorphisms in CYP24A1 and the risk and prognosis of CRC,as well as the combinations and inter-actions of polymorphisms with dietary factors on CRC risk.Results Although there was no association between polymorphisms in CYP24A1 and the risk of CRC,significant combinative effects between polymorphisms and diet-ary factors on CRC risk were observed.For Rs4809957 polymorphism,the prognosis of AA genotype carriers was worse than GG/GA carriers in CRC,colon cancer and rectal cancer(Log-rank test P=0.01,P=0.01,P=0.02,respectively).Compared with GG genotype,AA genotype carriers of Rs4809957 polymorphism had worse prognosis in CRC(HR =2.35,95%CI =1.28~4.30),colon caner(HR =2.37,95% CI =1.09~5.14) and rectal cancer(HR =2.11,95% CI =1.11~4.01).Conclusion The combinations of the polymorphisms in CYP24A1 gene with dietary factors are associated with the susceptibility of CRC,and Rs4809957 polymorphism may lead to a worse prognosis of CRC.

Purpose To explore the role of posterior cingulate cortex (PCC) dysfunction in the pathogenesis of depression and its relationship with the clinical features of depression by analyzing the effective connection among the inner areas of PCC of patients in depression.Materials and Methods The spectral dynamic causal model (spDCM) was used to analyze the resting state functional magnetic resonance imaging (fMRI) data from the PCC inner areas Brodmann area (BA) 23,BA29,BA30,BA31 in the major depressive disorder group (MDD,n=23) and healthy control group (HC,n=36).Results Compared with HC group,the strength of BA30 self-connection of MDD group existed significant difference (t=2.53,P＜0.05).In MDD group,the connection of BA23 toward BA31 had abnormal activation,and the abnormal inhibition occurred in BA23 toward BA30;compared with HC group and after a＜0.05 Hz correction,there were significant differences in the bi-directional connections for BA23 and BA31,BA39 and BA31,BA30 and BA31,and in the unidirectional connections for BA23 to BA31,BA30 to BA23,BA30 to BA29 in MDD group.Conelusion The effective connection and connective nodes and edges in the inner areas of PCC in the depression disorder patients were abnormal.

Objective To determine whether neuron?specific enolase(NSE)affects the prognosis of extensive small cell lung cancer by analyz?ing the association between NSE before treatment and disease progression and overall survival of patients. Methods This study retrospectively an?alyzed 83 inpatients in the medical oncology department of the First Affiliated Hospital of China Medical University from March 2008 to September 2014. The Kaplan?Meier method and Cox proportional hazards models were used to analyze relevant factors affecting the prognosis of extensive small cell lung cancer;statistical significance was determined for a P value less than 0.05. Results The lactate dehydrogenase(LDH)level be?fore treatment was significantly associated with the progression?free survival(PFS)(P=0.001)and overall survival(OS)(P=0.036). The NSE level before treatment was also significantly associated with the PFS(P=0.007)and OS(P=0.013). Conclusion LDH and NSE affect progno?sis and survival of patients with extensive small cell lung cancer.