Objective To observe the effect of extracorporeal shock wave lithotripsy on non target areas for various renal calculi. Methods Six thousand,one hundred and forty-nine cases of renal calculi patients were divided into 3 groups based on the calculi positions ,including the superior renal calices group ,the middle renal calices group and the inferior renal calices group. We compared the renal CT perfusion parameters in the non target areas of renal stones,successful rates of removing stones and complications. Results Extracorporeal shock wave lithotripsy had renal injures on both target areas and non target areas. When the extracorporeal energy is greater than 11 kV,the kidney damages became severe rapidly. When the E < 9,lithotripsy successful rate was signifi-cantly higher than that of E≥9;when E≥11 ,the energy wave lithotripsy complication rates were less than that of E<11 energy wave lithotripsy. Conclusions When the shock wave energy is in the range of 9~11 kV,there is not only low injuries on non target areas ,but also low successful rates of removing stones and complication rates. So the shock wave energy in a range of 9~11 kV is the best choice of energy regimen in treatment of patients with renal stones.