Objective To explore the clinical characteristics of postmenopausal patients with new-onset systemic lupus erythematosus(SLE).Methods The medical records of 289 patients with SLE in this hospital January 2015 to March 2021 were analyzed retrospectively.The patients were divided into the menopausal group(n=56)and the childbearing age group(n=205)according to whether they were menopausal at the time of onset.Male patients were divided into the male group(n=28).The differences in initial symptoms,clinical manifestations,laboratory indexes and SLE disease activity index(SLEDAI)scores among the three group were analyzed and compared.Results In the menopausal group,there were 5 cases aged 40-＜50 years old,31 cases aged 50-＜60 years old,14 cases aged 60-＜70 years old,and six cases aged ≥70 years old.37 cases occurred more than five years after menopause.Compared with the childbearing age group,the menopa-usal group had an older age of onset,a higher number of other diseases at the time of onset,a higher incidence of fever,edema,chest tightness and urgency as the first symptoms,weight loss,fatigue,myalgia and myasthe-nia,and a lower incidence of rash,kidney damage,WBC reduction,hemoglobin reduction,and of complement C3 and C4 reduction.The proportion of patients with SLEDAI score and SLEDAI score＞20 was lower(P＜0.05).Compared with the male group,the age of onset was older in the menopausal group,and the incidence of fever,edema,chest tightness and urgency as the first symptoms was higher,as well as the incidence of weight loss,myalgia and myasthenia,while the incidence of urinary surface foam as the first symptom and kid-ney damage were lower(P＜0.05).The most common laboratory abnormalities in postmenopausal group were ANA ≥1∶80,followed by anti-nucleosome antibody(+),anti-DS-DNA antibody(+),increased eryth-rocyte sedimentation rate,and decreased complement C3.Multivariate logistic regression analysis showed that compared with the menopause group,the risk of weight loss,myalgia and myasthenia was lower in the child-bearing age group,and the risk of kidney damage was higher(P＜0.05).Compared with the menopausal group,the male group had a higher risk of renal damage and a lower risk of complement C4 reduction(P＜0.05).Conclusion The first symptoms and clinical manifestations of postmenopausal SLE patients are atypi-cal,the organ damage is mild,and SLEDAI is low.

In order to cope with the increasing demand and complexity of hospital material management,the Third Affili-ated Hospital of Sun Yat-sen University introduced a whole-process integrated material management system in 2023.The system aims to realize the functions of automatic collection,dynamic monitoring,prediction and early warning and automation.This pa-per analyzes in detail the problems existing in the four aspects of demand identification,procurement management,material stor-age,warehousing and logistics transportation in the traditional material management mode.Through the introduction of the inte-grated management system for the whole process of materials,the basic functional platform of receiving information and dynamic monitoring of the whole process is built,and through the effective embedding of seven functional modules,all aspects of material management are fully covered,ensuring the accuracy and timeliness of material supply management,reducing management risks,and improving the overall service quality and clinical satisfaction of the hospital.This paper aims to provide an efficient and intel-ligent material management solution for hospital management team,and promote the high-quality development of hospitals.

Objective To strengthen the homogeneous management of logistics of multi-campus hospital and improve the quality and efficiency of logistics service in order to improve the satisfaction of logistics.Methods On the basis of existing serv-ice model,we developed the logistics intelligent integrated management platform,and used the information management method to realize the homogeneous service and standardized management.Results With the logistics intelligent integrated management platform,maintenance time was reduced,and logistics satisfaction was significantly increased.Conclusion The establishment of a one-stop logistics service model based on the logistics intelligent integrated management platform can enhance multi-hospital lo-gistics management and improve both quality and efficiency.

OBJECTIVE: To investigate the mutation of small sequence changes in microRNA-7 gene in Chinese patients with Parkinson's disease (PD). METHODS: We analyzed miR-7 variants in 225 PD patients from Chinese Han group by DNA sequence. RESULTS: None of the patients had miR-7 variants. CONCLUSION MiR-7 variation is not associated with PD in Chinese patients.
Aged ; Base Sequence ; China ; ethnology ; Female ; Humans ; Male ; MicroRNAs ; genetics ; Middle Aged ; Molecular Sequence Data ; Mutation ; Parkinson Disease ; genetics

Objective:To investigate the clinical features and prognosis of male with anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody.Methods:The clinical data of 246 patients with DM and anti-MDA5 autoantibodies hospitalized by Jiangsu Myositis Cooperation Group from 2017 to 2020 were collected and retrospectively analyzed. Chi-square test was performed to compared between counting data groups; Quantitative data were expressed by M ( Q1, Q3), and rank sum test was used for comparison between groups; Single factor survival analysis was performed by Kaplan-Meier method and Log rank test; Cox regression analysis were used for multivariate survival analysis. Results:①The male group had a higher proportion of rash at the sun exposure area [67.1%(47/70) vs 52.8%(93/176), χ2=4.18, P=0.041] and V-sign [50.0%(35/70) vs 30.7%(54/176), χ2=8.09, P=0.004] than the female group. The male group had higher levels of creatine kinase [112(18, 981)U/L vs 57 (13.6, 1 433)U/L, Z=-3.50, P<0.001] and ferritin [1 500 (166, 32 716)ng/ml vs 569 (18, 14 839)ng/ml, Z=-5.85, P<0.001] than the female group. The proportion of ILD [40.0%(28/70) vs 59.7%(105/176), χ2=7.82, P=0.020] patients and the red blood cell sedimentation rate[31.0(4.0, 101.5)mm/1 h vs 43.4(5.0, 126.5)mm/1 h, Z=-2.22, P=0.026] in the male group was lower than that of the female group, but the proportion of rapidly progressive interstitial lung disease (PR-ILD) [47.1%(33/70) vs 31.3%(55/176), χ2=5.51, P=0.019] was higher than that of the female group. ②In male patients with positive anti-MDA5 antibodies,the death group had a shorter course of disease[1.0(1.0, 3.0) month vs 2.5(0.5,84) month, Z=-3.07, P=0.002], the incidence of arthritis [16.7%(4/24) vs 42.2%(19/45), χ2=4.60, P=0.032] were low than those in survival group,while aspartate aminotransferase (AST)[64(22.1, 565)U/L vs 51(14,601)U/L, Z=-2.42, P=0.016], lactate dehydrogenase (LDH) [485(24,1 464)U/L vs 352(170, 1 213)U/L, Z=-3.38, P=0.001], C-reactive protein (CRP) [11.6(2.9, 61.7) mg/L vs 4.95(0.6, 86.4) mg/L, Z=-1.96, P=0.050], and ferritin levels [2 000(681, 7 676) vs 1 125 (166, 32 716)ng/ml, Z=-3.18, P=0.001] were higher than those in the survival group, and RP-ILD [95.8%(23/24) vs 22.2%(10/45), χ2=33.99, P<0.001] occurred at a significantly higher rate. ③Cox regression analysis indicated that the course of disease LDH level, and RP-ILD were related factors for the prognosis of male anti-MDA5 antibodies [ HR (95% CI)=0.203(0.077, 0.534), P=0.001; HR (95% CI)=1.002(1.001, 1.004), P=0.003; HR (95% CI)=95.674 (10.872, 841.904), P<0.001]. Conclusion:The clinical manifestations of male anti-MDA5 antibody-positive patients are different from those of female. The incidence of ILD is low, but the proportion of PR-ILD is high. The course of disease, serum LDH level, and RP-ILD are prognostic factors of male anti-MDA5 antibody-positive patients.