Objective To investigate the characteristics and differences of gastric flora in chronic non-atrophic gastritis and chronic atrophic gastritis associated with Helicobacter pylori(H.pylori).Methods A prospective study was adopted,and 24 patients with chronic gastritis caused by H.pylori infection were divided into chronic non-atrophic gastritis group(n=18)and chronic atrophic gastritis group(n=6).Characteristics of gastric mucosal flora in both groups were determined,and Alpha and Beta diversity analyses and species correlation analysis were performed.Results The gastric flora in both groups were mainly consisted of Proteobacteria,Bacteroidetes,Firmicutes,Actinobacteria,and Fusobacteria.Significant differences in species diversity and abundance were observed between the two groups(ANOSIM analysis,P=0.046).Fusobacterium(P=0.023),Leptotrichia(P=0.047),Prevotella(P=0.016),Sphingomonas(P=0.042),and Treponema(P=0.006)were significantly enriched in the chronic atrophic gastritis group,and H.pylori showed a decreasing trend(P=0.218).Some species of gastric mucosal flora showed negative correlations with H.pylori,and the number of species negatively associated with H.pylori in the gastric mucosal flora of chronic atrophic gastritis was significantly reduced.Conclusion In the gastric mucosa of chronic atrophic gastritis,the Fusobacterium,Leptotrichia,Prevotella,Sphingomonas,and Treponema are significantly enriched and associated with the progression of chronic gastritis.

Objective To investigate the characteristics and differences of gastric flora in chronic non-atrophic gastritis and chronic atrophic gastritis associated with Helicobacter pylori(H.pylori).Methods A prospective study was adopted,and 24 patients with chronic gastritis caused by H.pylori infection were divided into chronic non-atrophic gastritis group(n=18)and chronic atrophic gastritis group(n=6).Characteristics of gastric mucosal flora in both groups were determined,and Alpha and Beta diversity analyses and species correlation analysis were performed.Results The gastric flora in both groups were mainly consisted of Proteobacteria,Bacteroidetes,Firmicutes,Actinobacteria,and Fusobacteria.Significant differences in species diversity and abundance were observed between the two groups(ANOSIM analysis,P=0.046).Fusobacterium(P=0.023),Leptotrichia(P=0.047),Prevotella(P=0.016),Sphingomonas(P=0.042),and Treponema(P=0.006)were significantly enriched in the chronic atrophic gastritis group,and H.pylori showed a decreasing trend(P=0.218).Some species of gastric mucosal flora showed negative correlations with H.pylori,and the number of species negatively associated with H.pylori in the gastric mucosal flora of chronic atrophic gastritis was significantly reduced.Conclusion In the gastric mucosa of chronic atrophic gastritis,the Fusobacterium,Leptotrichia,Prevotella,Sphingomonas,and Treponema are significantly enriched and associated with the progression of chronic gastritis.

Objective To study placental microcirculation and microstructure of pregnant women with pregnancy-induced hyper-tension by using MRI intravoxel incoherent motion(IVIM)at plateau area.Methods A retrospective analysis was performed on 22 healthy pregnant women at third trimester with single birth and 20 pregnant women with pregnancy-induced hypertension.All subjects underwent ultrasound,routine MRI and IVIM examination.The D,D*,f values of the whole placental and various parts of the placental,estimated fetal weight(EFW)and postnatal weight were measured and recorded.The differences of two groups data were analyzed by independent sample t test or one-way analysis of variance,and then multiple comparisons of placental quantitative parameters between the two groups were analyzed by Bonferroni method.Results The fetal side and whole placental f values in healthy pregnant women at third trimester were higher than pregnancy-induced hypertension(P＜0.05),the maternal side and whole placental D values in healthy pregnant women at third trimester were higher than pregnancy-induced hypertension(P＜0.05),the EFW and fetal birth weight in healthy pregnant women at third trimester were higher than pregnancy-induced hypertension(P＜0.05).Conclusion IVIM can effectively evaluate placental blood flow microcirculation and microstructure with pregnancy-induced hypertension at plateau area,and provide a new proof for clinical evaluation of placental structure and function changes.