Objective To evaluate small molecule heparin allergic purpura complicated by long-term kidney damage intervention by Meta analysis.Methods Databases of CNKI,Wanfang,VIP,CBM and Cochrane Library were searched,hand searching as an auxiliary, included studies were assessed by quality of analysis, Meta-analysis was conducted by Stata12.1 software line.Results 4 articles were included in randomized controlled clinical trials (randomized controlled trials, RCT), a sample of 670 cases, 333 cases of small molecule heparin calcium treatment group (37 cases of renal damage has occurred), 337 cases of control group (44 cases of renal damage has occurred), no difference between the 2 groups (RR=0.89, 95% CI:0.59-1.34, P=0.578).Conclusion The early application of small molecular weight heparin calcium can not prevent kidney damage, it needs to do in-depth research by multi-center, large-scale RCT.

Objective:To explore the predictive value of helper T cell(Th)immune response indicators for asthma control in children with cough variant asthma(CVA)and its relationship with the risk of recurrence.Methods:A total of 112 children with CVA in Hengshui City People's Hospital from August 2020 to August 2021 were selected,all received conventional western medicine treat-ment,and were divided into well-controlled group(n=85)and poorly-controlled group(n=27)according to their asthma control status after 4 weeks of treatment.compare the general data,pulmonary function indexes before treatment[forced expiratory volume in 1 se-cond(FEV1),FEV1/forced vital capacity(FVC)],Th immune response indexes(Th1/Th2,IL-2,IFN-γ,IL-4,IL-10)levels,ana-lyze the correlation between Th immune response indicators and pulmonary function indicators,and predict the value of asthma control in children with CVA.After 6 months of follow-up,the recurrence situation in the well-controlled group was counted,the Th immune response indexes before treatment were compared between the children with recurrence and those without recurrence,and the relation-ship between Th immune response indexes and recurrence were analyzed.Results:Before treatment,the levels of FEV1,FEV1/FVC,Th1/Th2,IL-2 and IFN-γ in the poor control group were lower than those in the well-controlled group,and the levels of IL-4 and IL-10 were higher than those in the well-controlled group(P<0.05).Th1/Th2,IL-2,IFN-γ levels were positively correlated with FEV1,FEV1/FVC before treatment in children with CVA,and IL-4,IL-10 levels were negatively correlated with FEV1,FEV1/FVC(P<0.05);the areas under the curve(AUC)of Th1/Th2,IL-2,IFN-γ,IL-4 and IL-10 levels before treatment for predicting poor asthma control in children with CVA were all>0.7,and the combined predicted AUC(0.933)was the largest;before treatment,the levels of Th1/Th2,IL-2 and IFN-γ in the relapsed children in the group were lower than those of the non-relapsed children,and the levels of IL-4 and IL-10 were higher than those of the non-relapsed children(P<0.05);The levels of Th1/Th2,IL-2,and IFN-γ before treat-ment were negatively correlated with CVA recurrence,while IL-4 and IL-10 levels were positively correlated with CVA recurrence(P<0.05).Conclusion:Th immune response index has a certain value in predicting asthma control in children with CVA,and is closely related to the recurrence of CVA.

Objective To investigate the clinical value of serum interleukin-6(IL-6)and inter-leukin-8(IL-8)levels in combination with pulmonary function indicators in identifying severe Myco-plasma pneumoniae pneumonia(MPP)in children.Methods A total of 102 children with severe MPP were selected as the study subjects(severe group),and another 102 children with mild MPP treated during the same period were selected as the mild group.The serum levels of IL-6,IL-8 as well as forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1 percent-age of predicted(FEV1％pred)and the ratio of FEV1 to FVC at the time of admission of children in each group were compared.Results The serum levels of IL-6 and IL-8 in the severe group were sig-nificantly higher than those in the mild group,while the FVC,FEV,％pred,and FEV1/FVC％were significantly lower than those in the mild group(P＜0.05).The serum levels of IL-6 and IL-8 were negatively correlated with FVC,FEV1％pred and FEV1/FVC％(P＜0.05).The area under the curve(AUC)for assessing the severity of MPP for IL-6,IL-8,FVC,FEV1％pred and FEV1/FVC％was 0.894(0.849 to 0.939),0.842(0.787 to 0.897),0.896(0.851 to 0.942),0.787(0.725 to 0.849)and 0.744(0.676 to 0.812),respectively.The AUC for the combined assessment of the above five parameters was 0.985(0.973 to 0.997).Conclusion Serum IL-6,IL-8 and pulmonary function indicators can reflect the severity of MPP in children.Their combined detection can be used to differentiate between mild and severe MPP in children early and timely.

Objective To investigate the clinical value of serum interleukin-6(IL-6)and inter-leukin-8(IL-8)levels in combination with pulmonary function indicators in identifying severe Myco-plasma pneumoniae pneumonia(MPP)in children.Methods A total of 102 children with severe MPP were selected as the study subjects(severe group),and another 102 children with mild MPP treated during the same period were selected as the mild group.The serum levels of IL-6,IL-8 as well as forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1 percent-age of predicted(FEV1％pred)and the ratio of FEV1 to FVC at the time of admission of children in each group were compared.Results The serum levels of IL-6 and IL-8 in the severe group were sig-nificantly higher than those in the mild group,while the FVC,FEV,％pred,and FEV1/FVC％were significantly lower than those in the mild group(P＜0.05).The serum levels of IL-6 and IL-8 were negatively correlated with FVC,FEV1％pred and FEV1/FVC％(P＜0.05).The area under the curve(AUC)for assessing the severity of MPP for IL-6,IL-8,FVC,FEV1％pred and FEV1/FVC％was 0.894(0.849 to 0.939),0.842(0.787 to 0.897),0.896(0.851 to 0.942),0.787(0.725 to 0.849)and 0.744(0.676 to 0.812),respectively.The AUC for the combined assessment of the above five parameters was 0.985(0.973 to 0.997).Conclusion Serum IL-6,IL-8 and pulmonary function indicators can reflect the severity of MPP in children.Their combined detection can be used to differentiate between mild and severe MPP in children early and timely.