Objective To study the diagnostic value of reduced glutathione combined with Danshen powder injection on acute pancreatitis.Methods A total of 180 cases with acute pancreatitis were allocated into three groups:treatment group,control group 1 and control group 2 by random digits table method with 60 cases each.The relief time of abdominal pain,the duration of serum/urine amylase recovery,the duration of liver function damage recovery and the hospital stay time was compared.Results After the treatment,patients in treatment group showed better improvement in clinical symptom.The relief time of abdominal pain,the duration of serum/urine amylase recovery,the duration of liver function damage recovery and the hospital stay time in treatment group was shorter than that in control group 1 and control group 2[(2.9 ± 1.3) d vs.(4.1 ± 1.9),(4.5 ±2.3) d; (3.4± 1.2) dvs.(4.0±2.7),(3.9±2.1) d;(4.9± 2.1) d vs.(5.8±2.5),(6.1 ± 1.3)d; (6.7 ± 2.2)d vs.(8.6 ± 4.1),(9.5 ± 2.8)d; (8.1 ± 2.8)d vs.(9.8 ± 2.7),(10.3 ± 3.6) d],and there was significant difference (P ＜0.05).The total effective rate in treatment group was 96.7％ (58/60),which was higher than that in control group 1 and control group 2 [86.7 ％(52/60),83.3 ％ (50/60)],and there was significant difference (P ＜ 0.05).Conclusion Reduced glutathione combined with Danshen powder injection for acute pancreatitis can greatly decrease the serum inflammatory factors and improve the clinical efficacy.