Objective To explore the application effect of quality control circle in improving awareness rate of health knowledge among COPD patients. Methods 160 COPD patients treated in Department of Respiratory Medicine,Guangzhou Hospital of Guangzhou Military Command of PLA from March to December 2015 were selected,with the 80 admitted from March to May in 2015 as the control group,and the other 80 admitted from September to December in 2015 as the intervention group. Before the intervention,patients in the two groups were surveyed by a self-designed questionnaire on status quo of the COPD patients' health knowledge. Patients in the control group were instructed in a conventional way,while those in the intervention group were instructed by quality control circle activities. For patients in the intervention group,goal of this activity was set according to tesults of the survey,causal factors were analyzed and implementation countermeasures were made. Before leaving the hospital,patients in both groups were surveyed by the questionnaire again about their awareness on COPD health knowledge,basing on which,intervention effect was compared. Results After the intervention,awareness rate of COPD health knowledge among patients in the intervention group was 100%. Before the intervention,difference in awareness on COPD health knowledge between patients in the two groups was not statistically significant (P> 0.05). After the intervention,the awareness rate in the intervention group was higher than that in the control group (P<0.05). Conclusions Hospitalized COPD patients' awareness rate on health knowledge is low,which can be effectively improved by implementing quality control circle.