50 tracheotomy patients with mechanical breathing were performed respiratory tract control for suitable breathing. Result 5 patients recovered and had spontaneously breathing without respirator in 3~5days, then the trachea cannulas were pulled out in 1~2 weeks. Conclusion effective respiratory tract control may enhance the curative rate and improve patients' life quality.

Objective Multicystic renal cell carcinoma(MCRCC)appears to be a distinct subtype of renal cell carcinoma with characteristic gross and microscopic features.To explore the clinical and pathological features of MCRCC in order to find out its difference from renal clear cell carcinoma undergoing cystic change(RCCCC),and to propose prognosis criteria for therapeutic modalities.Methods From 1999 to 2003 32 patients were identified to have renal carcinoma,and they received radical or partial nephrectomy in the authors' institution.The pathological diagnosis was either MCRCC(n=21)or renal cell carcinoma associated with features of cystic changes(n=11).All specimens were reviewed histologically by two independent pathologists.The clinicopathologic and follow-up prognosis data on MCRCC and RCCCC were collected for study.Results 21 patients with MCRCC were 17 men and 4 women.The mean age at the time of surgery was 49 years(range 37 to 67 years).15 MCRCC patients with follow-up data were still alive with a mean follow-up time of 61 months(ranged 31 to 73)and no evidence of recurrence and metastasis was discovered.The mean survival time for 7 of the 11 patients with RCC was 32 months(ranged 18 to 63).There was significant difference in survival time between the two groups(P

BACKGROUND: Naomaitong injection is a Chinese herbal compound preparation for treatment of ischemic cerebral vascular disease, acting on resisting calcium overload, regulating the imbalance between thromboxane (TXA) and prostaglandin (PG) and blocking lipid peroxidation mediated by free radical so as to protect cerebrum.OBJECTIVE: To observe the effects of naomaitong injection on water and Ca2+ contents, activity of superoxide dismutase (SOD), levels of lipid peroxide (LPO), 6-keto-PG lα and TXA, and compare it with danshen injection.DESIGN: Randomized control experiment was designed.SETTING: Experimental Center of Chengdu University of Traditional Chinese Medicine.MATERIALS: The experiment was performed in Experimental Center of Chengdu University of Traditional Chinese Medicine from October 1997 to February 1998, in which, 72 healthy male Wistar rats were employed, rangroup: Abdominal injection was done with physiological saline 1.67 mL/kg,group): Abdominal injection was done with compound danshen injection groups (naomaitong No.1, No.2 and No.3 groups): abdominal injection was done with naomaitong injection 3.33, 1.67, 0.84 mL/kg successively,twice/day.METHODS: Totally 48 hours after medication, under anesthetized state,the rats in every group were sacrificed to collect brain tissue. The two hemispheres were cut into two pieces from the middle. One of them was prepared into brain tissue homogenate at low temperature. Radioimmunologic analysis method was used to measure 6-keto-PG 1o and TXA B2 levels so as to evaluate the balance between PG and TXA systems. The modified pyorgallol autoxidation and thiobarbituric acid (TBA) colorimetric method were applied to determine SOD activity and LPO level respectively so as to evaluate lipid peroxidation mediated by free radical. The dry and wet weights of other piece were weighed immediately on electronic scale and the water content of brain tissue was calculated to evaluate brain edema. Atomic absorption spectrophotometry (AAS) was used to determine Ca2+content in brain tissue so as to evaluate calcium overload.tissue of rats in every group.content in brain tissue of rats in every group: That in model group was higher remarkably than normal group [(82.27±1.32)%, (77.24±1.36)%;(267.47±15.69), (37.55±13.23) μg/g, P ＜ 0.01]. The water contents in 4 treatment groups were decreased of various degrees. The effect in No.1 group was the strongest [(78.74±1.41)%] and that in danshen group was the weakest [(81.45±1.52)%]. Ca2+ content in danshen group was decreased of various degrees, indicating dose-effect dependence, but, which was near to ty and LPO level in brain tissue of rats in every group: SOD activity in model group was lower remarkably than normal group [(86.18 ±3.17),(131.86±4.67) μkat/g, P ＜ 0.01]. After treated with naomaitong of 3 dosages, that was all improved, indicating dose-effect dependence (P ＜ 0.01). The effect of No.1 group was the strongest [(119.02±4.00) μkat/g],SOD activity in danshen group was near to model group (P ＞ 0.05). LPO level in model group was higher than normal group [(52.46 ±3.25),(32.29±2.23) μmol/L, P ＜ 0.01]. LPO level of every treatment group was lower significantly than model group and the therapeutic effects of No. 1, 2,3 groups were superior to danshen group [(35.68±2.86), (41.54±2.47),1α and TXA B2 in brain tissue of rats in every group: Content of 6-ketoPG 1α in brain tissue of model group was lower remarkably than normal group (P ＜ 0.01). That was improved in all of 4 treatment groups, in which,the therapeutic effects of No.1, 2, 3 groups were superior to danshen group [(43.84±2.98), (35.01±4.32), (29.97±3.81), (22.89±3.64) ng/g, P ＜ 0.01].TXA B2 content in brain tissue of model group was higher remarkably than normal group (P ＜ 0.01). After treatment, the 4 treatment groups lowed significantly TXA B2 content in brain tissue compared with model group,indicating dose difference. That in danshen group was lower than No. 1, 2,3 groups [(40.58±1.34), (32.85±1.43), (34.31±1.39), (37.27±1.52) ng/g, P ＜0.01].CONCLUSION: Naomaitong injection alleviates brain edema, resists calcium ion, regulates imbalance between TXA and PG systems, improves activity of anti-oxidase and is against injury of free radical so as to protect the structure of brain tissue and achieve therapeutic effects, indicating a certain dose-effect relationship. The effect of naomaitong injection is superior to that of compound danshen injection.

Leukemia is a malignant hyperplasia disease of hematopoietic system. It is characterized that a certain blood cell system proliferates, gets into blood streaming, infiltrates each organism and apparatus and arouse a series of clinical manifestation. In recent years the study of leukemia has discovered that it was correlated with apoptosis of the cells. The roles of XIAP and survivin in apoptosis inhibition have been especially paid attention. It is discovered that they play major roles in the genesis and resistance to chemotherapeutical drug of tumors. We summarize the biological characteristics and the expressions of XIAP and survivin in the children with acute leukemia.

Therapeutic effect of short-term administration of IFN-a on non-small cell lung cancer ( NSCLC) was observed . Seventy-two cases of NSCLC patients were randomized into two equal groups. The control and the IFN-a group received the same chemotherapeutic treatments while the latter group were also intramuscularly injected with IFN-? 1 ? 10~(6)U/day for 20 days. Treatment effect rate, the number of white blood cells, the growth of carcinoma cells and the in-terclude time of chemotherapy were studied. Statistically significant difference with each index was observed between the two groups. The results indicated that the short-term administration of IFN-? during chemotherapeutic suppression inhibited tumor growth and made a shortened chemotherapeutic treatment interval acceptable. All showed that administration of IFN-? was feasible and effective in NSCLC chemotherapeutic treatment.

Pneumatic pipe logistics delivery is feasible and important. The role and merits of pneumatic pipe logistics delivery are analyzed and scientifically demonstrated. Type 110 and type 160 systems are compared. Problems are solved. Pneumatic pipe logistics delivery promotes infrastructure service.

OBJECTIVE To investigate the relevant factors and drug sensitivity of Candida in nosocomial infection from a class A comprehensive hospital in Hangzhou in order to prevent and control nosocomial infection.METHODS We collected and identified clinic samples from inpatients during from Jan 2004 to Dec 2006 and drug resistance test was performed for Candida strains.The CHROMagar candida color medium and the Analytic Products Inc(API)20CAUX identification system were used to isolate and identify Candida strains from inpatients.The Etest was used to study the antifungal sensitivity.The data were analyzed by WHONET-5 software and were determined by the Clinical and Laboratory Standard Institute(CLSI)method.RESULTS Totally 264 strains of Candida were detected in the three years.The detection ratio in each year was 78 strains(29.5%),87 strains(32.9%),and 99 strains(37.5%),respectively.The C.albicans was the most commonly isolated species(65.5%)and then was C.tropicalis(15.1%)in all Candida species.The detection ratio was the highest in sputum samples(108 strains,40.9%)and the patients with respiratory tract infection(58 strains,22%).The results of antifungal drug sensitivity test showed that Candida were the most susceptive to amphotericin B,followed by fluconazole.The results of change showed that Candida remained stable susceptive to amphotericin B,but susceptive ratio to fluconazole was descent in the three years.CONCLUSIONS Candida in nosocomial infection are an increasing tendency and C.albicans is the commonest.Sensitivity of Candida to various antifungal drugs is different and there is a developing change in susceptive ratio to antifungal drugs.Strengthening supervising relevant factors and improving the immunity of organism are the main measures to prevent Candida in nosocomial infection.Antifungal drug should be used reasonably based on drug sensitive test.

Objective To better understand the treament effect of postexposure after biting by dogs and other animals in,Cixi city,and to provide evidence for rabies control.Methods The people,who were bitten by dogs and other animals,were investigated.All related information was collected such as the date and site of bite,animal species,postexposure treatment including vaccination and anti-rabies serum or human anti-rabies immune globulin.Results Total 21,504 cases had received the postexposure treatment from January to September in 2007.Among 21,504 people,95% were attributed to dog bites.62% of people had received the treatment within 12 hours after exposure.All people had received five doses of vaccine.Total 783 people had been administered anti-rabies serum.Furthermore,no sever side effect and rabies cases occurred among these people.Conclusions The injury caused by dogs was still a major potential factor to cause rabies in the rabies endemic area.The timely and correct postexposure treatment with good quality of vaccine could prevent from rabies.

Matrix metallopmteinase(MMP),a family of proteolytic enzymes,can degradate the composition of extracellular matrix.Its structure,regulatory function and physiopathology have been deeply studied,and its role in tumor metastasis has received more attention.The tissue inhibitor of metalloproteinase(TIMP),as an endogenous MMP inhibitor,suppresses both the form and course of MMP activation.The function zone of its C-end accords with some other parts of MMP,forming an MMP-TIMP compound,to block the combination of MMP with the substrate,suppress the activation of MMP,and slow down or block the invasion and metastasis of osteosarcoma.

Objective To determine the efficacy and safety of hysteroscopic resection with dipolar electrodes for submucous myoma of the uterus. Methods By hysteroscopy combined with B-ultrasonography,totally 456 cases of submucous myoma of the uterus were confirmed in our hospital from January 1998 to December 2007. Among the patients,241 cases showed type 0,138 patients were type Ⅰ,and 77 cases were type Ⅱ. In 341 of the cases,the myoma sized 1.0 to 2.0 in diameter,86 cases from 2.1 to 4.0 in diameter,and the other 29 cases had the myoma ranged from 4.1 to 6.0 cm in diameter. Hysteroscopic resection with dipolar electrodes were performed on all the cases,among which microelectrode was used in 341 patients,and ring electrode was employed in 115 cases. Results The operation time ranged from 9 to 55 min with a mean of (32.9?16.7) min. The removed tissues weighed (30.2?8.2) g in average (ranged from 5 to 55 g). During the operation,the patients had 5 to 100 ml blood loss [mean,(48.1?12.7) ml]. No complications occurred during and after the operation. The patients were followed up for three months,during which 431 (94.5%) showed reduced menstruation and decreased menstrual blood loss,only 5 patients (1.1%,all were type Ⅱ) had residual myoma. In this series,totally 42 patients wished pregnancy,15 of them became pregnant in 24 months postoperation. After the treatment,anemia was corrected in 206 patients with the level of Hb increased to a normal range;before the operation,81 patients had menstrual pain,42 of them were relieved and 19 were improved by the operation,while the other 20 showed no changes in the symptoms. Conclusion Hysteroscopic resection with dipolar electrodes is safe and effective for uterine submucous myoma.