Bilateral sequential cataract surgery is very common in clinical,but the ophthalmologists often ignore how to choose the timing of operation and whether the first eye can be used to improve the intraocular lens (IOL) power calculation for the second one.Despite the refinements in IOL selection with the use of third-generation IOL formulas,5％ of eyes still result in a postoperative refractive surprise of ± 1.00 D or more.This paper introduced the methods of using refraction error of the first eye to improve the IOL power calculation for the second eye,and the refractive error of the second eye can be improved by modifying the IOL power to correct up to 50％ of the error from the first eye in details.Because of the variation of the postoperative refractive surprise within a month,the interval of three to four weeks between two eyes cataract surgery is highly recommended.These conclusions may provide the advantageous guidance for us in the selection of IOL in bilateral cataract surgery.

OBJECTIVE: To characterize the pharmacokinetics of a single dose of 2.5 mg fondaparinux sodium in Chinese patients after thoracic surgery. METHODS: Thirteen patients were enrolled in the study and were given a single dose of 2.5 mg fondaparinux sodium via a subcutaneous injection. Plasma concentrations of fondaparinux sodium were measured throughout a 24 h period. The pharmacokinetic analysis was performed using WinNonlin software. RESULTS: The following pharmacokinetic parameters were derived; t1/2(7.92 ± 3.13) (4.21-15.89) h, tmax(2.52 ± 0.93) (1.38-4) h, p-1 (0.73 ± 0.18) (0.45-1.02) mg · L-1, AUClast(6. 56 ± 2.19) (3.07-9. 75)mg · h · L-1, Vz/F(3.54 ± 1.00) (2.24-5.73) L, CL/F(0.34 ± 0.14) (0.16-0.63) L · h-1, and MRTlast (6.98 ± 2.1) h. The pearson correlation coefficient, r was 0.7283(P = 0.005) between the serum creatinine(Scr) and mean residence time(MRTlast) of fondaparinux. CONCLUSION: The disposition of fondaparinux is highly variable in patients. A statistical significant correlation between Scr and MRTlast of fondaparinux was observed. Fondaparinux sodium administered by intravenous injection is well tolerated in patients.

MicroRNA is a type of endogenous noncoding small molecular RNA with a length of 19-25 nucleotides. MicroRNAs are involved in almost all key biological processes, such as cell proliferation, differentiation, apoptosis, and hematopoiesis, via repres-sion of target gene expression. Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer. It is a heterogeneous disease with different clinical signs, morphology, immunophenotype, and cytogenetics. Currently, several microRNAs have implicated aberrant expression in ALL and play an important role in cancer initiation and development. MicroRNA expression pattern is associated with clinical feature, prognosis, and treatment. Therefore, microRNAs could act as a novel marker to help scientists learn about the pathogenesis of ALL and to provide more effective treatment options.

Research on CellSearch system's detection rate of cells and linearity performance detection method, so as to analyze the accurate and reasonable detection method to meet the CellSearch characteristics of the system.
Biomarkers, Tumor ; Cell Line, Tumor ; Cell Separation ; methods ; Humans ; Neoplastic Cells, Circulating

The microarray technology used in biological and medical research provides a new idea for the diagnosis and treatment of cancer. To find different types of cancer and to classify the cancer samples accurately, we propose a new cluster ensemble framework Dual Neural Gas Cluster Ensemble (DNGCE), which is based on neural gas algorithm, to discover the underlying structure of noisy cancer gene expression profiles. This framework DNGCE applies the neural gas algorithm to perform clustering not only on the sample dimension, but also on the attribute dimension. It also adopts the normalized cut algorithm to partition off the consensus matrix constructed from multiple clustering solutions. We obtained the final accurate results. Experiments on cancer gene expression profiles illustrated that the proposed approach could achieve good performance, as it outperforms the single clustering algorithms and most of the existing approaches in the process of clustering gene expression profiles.
Algorithms ; Cluster Analysis ; Gene Expression Profiling ; methods ; Humans ; Neoplasms ; genetics ; Transcriptome

Chloasma is a kind of skin disease with pigmentation on the face, which can be frequently seen in child-bearing age women. The disease is caused by Zangfu dysfunction, Qi and blood deficiency. For women, the generation of chloasma is closely related to their menstruation. Regulating the menstrual function with traditional Chinese medicine and balancing the body's internal environment can be very useful for achieving the balance between Yin and Yang within Zangfu, and regulating Qi and blood, which will not only desalt pigment, but also can improve the symptom related to menstruation with low recurrence rate after drug withdrawal. This method can be used alone or with other methods in clinic, has achieved significant effect.

The difference in history of development, the curriculum and teaching content of medical humanities education have been compared and researched among the United States, Britain and China, and the questionnaire survey have been conducted to the students from HeBei Medical University, to find the disadvantages and willingness to reform in medical humanities education in China. Based on the successful experience on Medical Humanistic Education from foreign countries, suggestions were put forward such as increased emphasis on medical humanities education, reasonable arrangements for medical education curriculum, creating a good atmosphere on campus, making the medical education to match the social demand, and providing scientific basis for the development of medical humanities education.

Objective To investigate the correlation between the inflammatory-nutritional index (INI) and recurrence and prognosis in patients with gastric cancer. Methods A total of 78 cases patients of gastric cancer with recurrence and 64 cases without recurrence were enrolled. INI was calculated by the ratio of serum albumin and C-reactive protein. The value of INI predicting recurrence was analyzed using receiver operating characteristic curve (ROC). According to this value, the Kaplan-Meier curves and Cox regression analysis were used to evaluate the effect of INI on prognosis. Results Compared with the control group, the recurrence group showed smaller INI, larger tumors, lower degree of differentiation, deeper invasion and higher TNM stage, the differences were statistically significant (all P < 0.01); The INI significantly predicted the recurrence of gastric cancer, with a sensitivity of 62.5%, specificity of 79.5% and critical value of 0.36 (P < 0.01); Additionally, The pathological features were worse in the low INI group than the high INI group , the differences were statistically significant (P < 0.01); The INI significantly predicted the prognosis of gastric cancer, with a sensitivity of 65.9%, specificity of 66.8% and the critical value of 0.34 (P < 0.01); Obviously, the survival rate was lower in the low INI group than the high INI group (48.8% vs 25.0%, P < 0.01). Furthermore, INI was an independent risk factor for prognosis of gastric cancer (OR = 1.78, 95% CI: 1.34 ~ 2.59, P < 0.01). Conclusion The INI is closely related to the characteristics of gastric cancer, it is an effective marker to predict recurrence and prognosis of gastric cancer.

China faces opportunities and challenges as well when it participates in global environment and health governance. Major opportunities are as follows:(1) The convergence between global environment and health governance’s future trend and China’s environment and health strategies is a strongest incentive to push China to par-ticipate in global environment and health governance;(2) China can benefit from this participation in term of more access to international resources; ( 3 ) Global environmental and health issues are the areas that can best illustrate China’s international image as a responsible member; ( 4 ) Since global environmental and health governance is still young, early participation will give China a louder voice in its decision-making. The challenges that China faces are as follows:(1) Huge pressure from domestic environment and health challenges forces China to be primarily inward-looking and makes it very hard for the country to keep a high profile in global environment and health governance. China also faces the increasing international pressure. ( 2 ) The lack of global environment and health governance strategy prevents China from effectively participating in global environment and health governance. (3)“The Grand Health Outlook”hasn’t been fully established yet in China, leaving much room for improvement. (4) Intellectual sup-port is inadequate. (5) Some countries have too high expectations of China in terms of its contribution to global envi-ronmental and health governance. In order to effectively participate in this field, China should undertake coordinated planning on both the international and domestic scenes, and take some specific policies both at national and interna-tional level.

Iodine is an essential trace element,its physiological function is realized through thyroid hormone,both iodine deficiency and excess have influences on human health.After 20-year implementation of universal salt iodization in China,the iodine deficiency disorders have been controlled effectively,while the problem of iodine excess emerged.Because of different geographical environment,dietary habits and physiological status,some people did exposed to high level of iodine.In recent years,domestic and foreign scholars carried out series of researches aiming at disclose the effects of iodine excess on human health.The health problems induced by high iodine intaking are goiter,hyperthyroidism,hypothyroidism,autoimmune thyroiditis and thyroid cancer et al.Therefore,when preventing and treating iodine deficiency,iodine excess should also be avoided,so as to achieve the ideal goal of adjust measurements according to local conditions,classification guidance,and scientific iodine supplementation.