English-teaching among medical students is an important method to improve the teaching quality of foreign students and to train medical professionals capable of international communi cation.In the English-teaching among foreign and native undergraduate students,the course wares and teaching methods were designed after summarizing the features of students and teaching contents and were further improved during the practice.The continuing improvement of teachers′ English proficiency is also necessary to achieve good teaching quality.

Amino Acid Metabolism, Inborn Errors ; etiology ; therapy ; Glutarates ; blood ; Humans ; Infant, Newborn ; Male

Objective To identify whether abnormal clinical manifestations of dysphagia in stroke patients could predict associated imaging abnormalities. Methods Clinical evaluations and videofluoroscopy were performed on 56 consecutive cases of stroke. The clinical and image manifestations of dysphagia were observed and analyzed u-sing logistic regression analysis. Results A bolus leaking from the mouth was found (P =0.037) to predict abnormal lip closure. Raising the head when swallowing (P =0.010) and dysarthria (P =0.025) were found to predict reduced tongue movement. Exertion in swallowing (P = 0.016) could predict poor laryngeal elevation. Abnormal la-ryngeal elevation (P =0.024) and reduced or absent gag reflex (P =0.005) were found to predict insufficient epiglottis tilt down. Coughing caused by swallowing could predict incomplete vocal fold closure (P =0.011) and aspiration (P = 0.042). Conclusion Videofluoroscopic manifestations could be predicted to some extend by some clinical swallowing abnormalities, which could increase the accuracy of clinical evaluation and help in the management of dysphagia in those who could not endure videofluoroscopy.

This review was made to compare the multimedia teaching results with traditional teaching results in medical universities or colleges.Two kinds of opposite viewpoints appeared:the multimedia teaching results was better or worse than the latter.

Objective Videofluoroscopy could identify the pathophysiologic changes of swallowing and be help to make management plan. The study was to identify image manifestation and characteristics of dysphagia in stroke under X-ray. Methods Videofluoroscopy were performed in 56 stroke inpatients and 30 healthy volunteers who drunk 1, 3 and 5 ml barium with viscosity of 60%w/v, 180%w/v and ate half piece of cake smeared with barium. Abnormal swallowing and quantitative measurements in antero-posterior and lateral position were recorded. Chi square test and Logistic regression analysis were used to identify abnormal swallowing associated with accidental aspiration. Rank test and t test were used to analysis the difference of quantitative measurements between control and accidental aspiration group. Results All the swallowing apparatus could be injured after stroke which led to a variety of abnormal oral and pharyngeal swallowing including decreased tongue and palate motility, insufficient glottis closure, delayed swallowing, accidental aspiration etc. All patients presented abnormality in pharyngeal phase and 46 in oral phase. Compared with that of volunteers, height and velocity of larynx elevation decreased, opening width of cricopharyngeal muscle reduced and swallowing latency prolonged in dysphagia patients. Accidental aspiration was seen in 34 patients, of whom 14 patients presented silent aspiration. Statistic analysis showed that decreased tongue movement(P=0.021), poor tongue-hard palate contact (P=0.021), insufficient glottis closure(P=0.011), decreased height and velocity of larynx elevation(P=0.003), delayed swallowing (P=0.001) and penetration (P=0.000) were associated with accidental aspiration. Conclusions Stroke may injure all the swallowing apparatus, more frequently in pharyngeal phase. Tongue weakness, insufficient glottis closure, poor larynx elevation, delayed swallowing and penetration are associated with accidental aspiration.

OBJECTIVE:To explore clinical efficacy and compliance of different doses of calf pulmonary surfactant combined with nasal intermittent positive pressure ventilation (NIPPV) in the treatment of neonatal respiratory distress syndrome (NRDS). METHODS:90 children diagnosed as NRDS were collected from neonatal department of our hospital,and were divided into high-dose group,middle-dose group and low-dose group by random number table method,with 30 cases in each group. 3 groups received NIPPV combined with calf pulmonary surfactant;the dose of calf pulmonary surfactant in high-dose group,middle-dose group and low-dose group were 100,70,40 mg/kg,respectively. Blood gas indexes,treatment,hospitalization duration,treatment cost,the incidence of compliance were compared among 3 groups. RESULTS:Before treatment,there was no statistical signifi-cance in pH,PaCO2,PaO2,SaO2 among 3 groups(P>0.05);after treatment,above indexes of 3 groups were all improved signifi-cantly,and the high-dose group was significantly better than middle-dose group and low-dose group,with statistical significance (P<0.05). There was no statistical significance in duration of ventilation,oxygen therapy duration,cure rate and treatment cost among 3 groups(P>0.05). Medication times and hospitalization time of high-dose groups were significantly lower or shorter than those of middle-dose group and low-dose group,with statistical significance (P<0.05). The rate of complication in high-dose group,middle-dose group and low-dose group were 20.0%,23.3% and 16.7%,respectively,there was no statistical significance (P>0.05). CONCLUSIONS:Calf pulmonary surfactant combined with NIPPV could effectively improve the blood gas status of newborn with NRDS. High dose of calf pulmonary surfactant can reduce hospitalization time and doesn’t increase treatment cost and the rate of compliance.

OBJECTIVETo observe the changes of mitochondria stress in locus coeruleus and the tyrosine hydroxylasic projection after long-term sleep deprivation.

METHODSSleep deprivation mice model was set up by employing "novel environments" method. The expression of NAD -dependent deacetylase Sirtuin type 3 (SIRT3), which regulates mitochondrial energy production and oxidative stress, and heat shock protein 60 (HSP60), a major biomarker of mitochondrial stress, and the tyrosine hydroxylasic projection from locus coeruleus were analyzed after a 5-day sleep deprivation.

RESULTSCompared to the control group, the expression of SIRT3 in locus coeruleus was significantly decreased in respouse to long-term sleep deprivation, while the expression of HSP60 was significantly increased. In addition, relative to control group, pereentage area of the tyrosine hydroxylasic projection to anterior cingulate cortex was substantial decreased in long-term sleep deprivation group.

CONCLUSIONLong-term sleep deprivation induced the decreased level of SIRT3 expression and the elevation of mitochondrial stress in locus coenileus, which may further lead to the loss of tyrosine hydroxylasic projection in mice.

Animals ; Chaperonin 60 ; metabolism ; Locus Coeruleus ; metabolism ; physiology ; Mice ; Mitochondria ; metabolism ; Mitochondrial Proteins ; metabolism ; Oxidative Stress ; physiology ; Sirtuin 3 ; metabolism ; Sleep Deprivation ; Tyrosine ; metabolism

Objective To know the blood lead level among twins in Ji’ning,Shandong province,China and to assess the genetic and environmental influence on blood lead level of children. Methods A total of 144 pairs of same sex twins aged 6-14 years were randomly selected in June,2008,and their blood lead level was determined and assessed into three groups,namely the relatively safe group (blood lead level

Plasma concentrations of immunoreactivc beta-endorphin in patients with NIDDM were measured by radioimmuno-assay. It was found that the plasma beta-endorphin levels decreased in 68 cases of NIDDM especially in those with long duration of illness and chronic complication. These results suggested that beta-endorphin may be related to diabetes and its chronic complication.

Immunoreactive beta-endorphin was measured by radioimmunoassay (RIA) in the pituitary, hypothalamus, pancreas and plasma of female diabetic rats induced by streptozotocin. In addition, pain threshold was determined. The results showed that the concentrations of beta-endorphin in pituitary, hypothalamus, pancreas and plasma began to decrease on the first month after being made diabetic. Then, the levels of beta-endorphin continued to decrease significantly as the course progressed, especially in pancreas and plasma. Diabetic rats consistently showed a decreased pain threshold after 4 weeks. These results suggested that the decrease of beta-endorphin may be related to the course of diabetes and pain threshold.