The aim of this review is to detect the difference in outcome of cardiac resynchronization therapy (CRT) between ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM).By reviewing some clinical trials of large scale,we found that restore of heart structure and function in NICM was more significant than ICM.However,there were no significant differences in clinical outcome of improving cardiac function and quality of life,decreasing heart failure re-hospitalization and mortality.

Objective To investigate the effect of herbs for nourishing kidney and strengthening governor vessel on postoperative intervertebral fusion rate in elderly patients with degenerative lumbar spinal stenosis ( DLSS) . Methods A retrospective analysis was carried out for the clinical data of 72 elderly DLSS patients treated with modified transforaminal lumbar interbody fusion (TLIF) during the period from October, 2012 to October, 2013. The patients were divided into two groups, 39 in Chinese medicine group and 33 in control group. Operative efficacy was evaluated with Japanese Orthopaedic Association ( JOA) scores for assessment of cervical myelopathy, postoperative function improvement was evaluated by Oswestry disability index (ODI) scores, and lumbar interbody fusion was evaluated by the modified Brantigan scores. Results (1) During the follow-up period, patients of the two groups had no complications such as screw breaking or loosening, cage displacement, or endplate collapse. (2) Before opera tion and 3 days after operation, the differences of JOA scores were insignificant between the two groups (P>0.05) . (3) Significant difference of intragroup ODI scores were shown 12 months after operation vs 6 months after operation, and between 6 months after operation and pre-operation in the two groups (P<0.01) . ODI scores of Chinese medicine group 6 and 12 months after operation were lower than those of the control group, the difference being significant ( P<0.05 or P<0.01) . ( 4) The results of modified Brantigan scoring showed that the interbody fusion rate 6 months after operation was 71.79% in Chinese medicine group, higher than 48.48% in the control group ( P<0.05) . Twelve months months after operation, the interbody fusion rate was 87.18% in Chinese medicine group, higher than 66.67% in the control group (P<0.05) . Conclusion Herbs for nourishing kidney and strengthening governor vessel may improve the lumbar interbody fusion rate and the quality of life of the elderly DLSS patients treated by modified TLIF.

OBJECTIVE:To improve the quality of pharmaceutical service and to promote rational drug use in clinical practice.METHODS:According to in-patients'medical record and information of drug use,SOAP electronic pharmaceutical care database was established by using Microsoft Visual Foxpro6.0software.RESULTS:The established pharmaceutical care database had the advantages of huge information storage and rapid inquiry system and report output.CONCLUSION:This method is simple and convenient and can improve the efficiency of pharmaceutical work and serve patients better.

Objective To evaluate the bactericidal effect of diode laser on Porphyromonas gingivalis (Pg),and to explore an optimized protocol for a safe dose of photodynamic therapy (PDT) to eliminate periodontal pathogens as well as the impact on the implant surfaces,so as to provide theoretical and experimental basis for PDT in periimplantitis therapy.Methods Artificial in vitro models were formatted by culturing Pg standard strain and ITI (International Team for Implantology) implants together in CDC broth.Then artificial in vitro models were treated by different doses of hematoporphyrin monomethyl ether (HMME) and different energy density of laser (EDL) for 60 s.The cultures were counted by colony form unit (CFU),and SPSS 17.0 statistical software was used for data statistical analysis to select the best EDL and HMME dose.Finally,ITI implants were observed by scanning electron microscope (SEM) to evaluate the impact of HMME-PDT on Pg of implant surfaces.Results When EDL was 12 J/cm2 and mass concentration of HMME was 25 μg/ml,SEM observations showed that PDT could effectively kill Pg ((13.00±5.00) CFU)without damaging the implant surfaces.Conclusions PDT therapy combining 630 nm diode laser with photosensitizer HMME have good bactericidal effect on Pg,and the EDL and HMME dose is as small as the clinical applicable safe dose.

BACKGROUND:Bone marrow mesenchymal stem cels are a kind of non-hematopoietic adult stem cels, mainly distributing in the bone marrow, with strong proliferation and differentiation potential, which has a promising clinical prospect. OBJECTIVE:To review the latest progress in growth factors and biological scaffolds to promote chondrogenic differentiation of bone marrow mesenchymal stem cels. METHODS:PubMed and CNKI databases were searched by the first author using key words of cartilage defects, tissue engineering, biological scaffolds, bone marrow mesenchymal stem cels, cytokines in English and in Chinese, respectively, to retrieve relevant articles published from 1990 to 2014. Literatures addressing the chondrogenic differentiation of bone marrow mesenchymal stem cels were included, and 51 articles were chosen for further analysis eventualy. RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cels have the potential to differentiate into chondrocytes, which can be induced by many cytokines. Various biological scaffolds act as a carrier for chondrogenic differentiation of bone marrow mesenchymal stem cels. But there are stil lots of problems to be solved and in-depth explored clinicaly.

Objective:To investigate the clinical efficacy and outcomes of two separate vertical wiring combined with tension band and Kirschner-wire plus cerclage wire in the treatment of displaced inferior pole fractures of the patella.Methods:From January 201 3 to January 201 5,1 5 consecutive patients (mean age 54.5 years)with inferior pole fractures of the patella were retrospectively included in this study.All the patients underwent open reduction and internal fixation by separate vertical wiring com-bined with tension band and Kirschner-wire plus cerclage wire through longitudinal incision,4.5 d (range:3.1 -5.9 d)after initial injury.A safety check for early knee range of motion was performed before wound closure.The complications including infection,nonunion,loss of fixation and any wire breakage or irritation from implant were recorded.Anteroposterior and lateral views of the knee joint ob-tained during the follow-up were used to assess bony union based on the time when the fracture line disap-peared.At the time of the final outpatient follow up,functional evaluation of the knee joint was conduc-ted by B?stman system.Results:The follow-up time was 1 3.1 months (range:1 2 -1 9 months)after surgery on average,immediate motion without immobilization in all the cases was allowed and there was no case of reduction loss of the fracture and wire breakage.There was no case of irritation from the im-plant.At the final follow-up,the average range of motion (ROM)arc was 1 26.7°(range:1 1 5°-1 40°),the average ROMlag versus contralateral healthy leg was 1 0.3°(range:0°-35°).The mean B?stman score at the last follow-up was 28.9 (range:27 -30),and graded excellent in most cases. Conclusion:Two separate vertical wiring is an easy and effective method to reduce the displaced inferior pole fracture of patella.Augmentation of separate vertical wiring with tension band and Kirschner-wire plus cerclage wire in these patients provides enough strength to protected the early exercise of the knee joint and uneventful healing.By this surgical treatment,excellent results in knee function can be expec-ted for cases of displaced inferior pole fractures of the patella.

OBJECTIVE:To discuss the thoughts over the event of“armillarisin A”produced by Qiqihar No.2Pharmaceut ical Co.Ltd.METHODS:Citing the event of“armillarisin A”produced by Qiqihar No.2Pharmaceutical Co.Ltd.as example,we analyzed problems occurred in the process of production and management of pharmaceuticals and traced the root causes.RESULTS&CONCLUSIONS:Pharmaceutical enterprises should bear in mind their social responsibility and leave no loophole in the control and supervision of drugs,they should draw lessons from this event and prevent the similar event from happening again by working out effective measures to tighten controls on the quality of drug production,registering and approval,circulation,ADR reporting,etc.

OBJECTIVE:To ensure patients'rights of knowing the fact of medication.METHODS:The characteristics of medical care and the chief problems existed at present were analyzed.The significance and the necessity of ensuring patients'rights of knowing the fact in medication in hospital were discussed and some specific measures were proposed.RESULTS&CONCLUSION:Ensuring patients'rights of knowing the fact in medication embodies hospital's demand for"taking people as top priority",building a harmonious society,upgrading hospital's image and promoting rational drug use,which deserves great attention from the relevant hygiene authorities and hospital leaders.

Objective To investigate the long term efficacy and safety of thalidomide in the treatment of refractory ankylosing spondylitis.Methods A total of 232 patients with refractory ankylosing spondylitis were recruited into open study using thaiidomide at a dose of 150 mg/d, bath ankylosing spondylitis disease activity index ( BASDAI) , spinal pain score and thaiidomide related side effects were observed regularly.Results From the third month, BASDAI and spine pain score decreased significantly when compared with those of the base line ( P < 0.05).Such improvement became more obvious as time went on.A total of 148 patients (63.8% ) got >50% improvement in BASDAI and spine pain score, and 76 cases (32.8% ) reported absence of spine pain.The major side effects were drowsiness, constipation, dry mouth, dizziness and dandruff.Thirty two patients (13.8% ) withdrew from the study because of adverse events.Most of the adverse effects disappeared as thaiidomide was stopped.Conclusion Long term thaiidomide is effective and safe for treating resistant ankylosing spondylitis and it has cumulative effect as duration prolongs.

Objective To evaluate the clinical application of intraluminal stent angioplasty(PTRAS) in the treatment of renal arterial stenoses. Methods A retrospective study was done in 28 patients with renal arterial stenoses. Primary renal artery stenting was performed in 28 consecutive patients (36 renal arteries). Blood pressure, serum creatine, the number of anti hypertensive medications were recorded at 1,6,12 month post stent angioplasty respectively. Arterial angiography was also taken 1 year later to evaluate the incidence of restenosis. Results Technical success rate was 100% achiving in all patients without serious complications. Primary successful patenty rate reached 82% (renal artery 86%), secondary successful rate was 89% (renal artery 90%). Systolic and diastolic blood pressure were reduced significantly ( P