Based on the analysis of Language Learning Strategies of foreign language learners and their characteristics,this paper illuminates that training on Language Learning Strategies in regular language classes helps foreign language learners become successful and independent learners.

Objective To investigate psychological pressure sources of emergency nurses who were assigned to emergency intensive care unit(EICU)and put forward countermeasures.Methods We collected data by phenomenological method of qualitative study.Thirteen nurses who had worked in EICU for at least six months were interviewed.The collected data we analyzed by Colaizzi analysis method.Result The psychological pressure had its sources from 4 main aspects: nursing skills,increasing labor intensity,communications with patients and shortage of staff.Conclusion Nursing administration should actively take measures to relieve the psychological pressures of the emergency nurses who were assigned to EICU so as to improve the nurses’working enthusiasm and the nursing quality of EICU.

Objective To investigate the role of TRAF2 in AP-1 signaling pathway of human B cells.Methods Human Ramos B cells were transfected with plasmids expressing YFP fusion wild type TRAF2(YFP-WT-TRAF2) or YFP fusion dominant-negative TRAF2(DN-TRAF2),or transfected with shRNA-TRAF2 and control shRNA plasmid.After incubation overnight,cells were either sorted with flowcytometry or screened by antibiotics G418.Activation of AP-1 pathway,including phosphorylation of ERK,JNK and P38,as well as nuclear translocation of AP-1 subunits were detected by western blot and ELISA.Results Overexpression of WT-TRAF2 selectively induced activition of MAPK by phosphorylation of ERK and P38,and further induced nuclear translocation of C-FOS.Moreover,both overexpression of DN-TRAF2 and transfection of shRNA-TRAF2 inhibited phosphorylation of ERK and P38,and nuclear translocation of C-FOS.Conclusion TRAF2 selectively activates some kinases in CD40 mediated AP-1 signaling pathway,and plays an important role in AP-1 activation.

Objective To investigate the efficacy and mechanism of Tanshinone ⅡA for treatment on acute cerebral infarction(ACI). Methods 104 patients with ACI were randomly divided into Tanshinone group (50 cases) and control group (54 cases),and were treated with conventional therapy. While,Tanshinone ⅡA was added by intravenous drop in Tanshinone group for 2 weeks. Neurological functional deficit scores,Barthel index(BI) were observed,the levels of serum superoxide dismutas(SOD),lipid peroxide (LPO) and malondialdehyde (MDA) were detected pre and post treatment. The efficacy was compared in the two groups.Results After 2 weeks of treatment,the score of National institute of health stroke scale (NIHSS) was decreased,BI was increased,the level of serum SOD was increased,the levels of serum LPO and MDA were decreased in the two groups. Compared with those in pre treatment,the changes of all the targets were significantly different (all P

B cells play a central role in the pathogenesis of rheumatoid arthritis(RA) through multiple mechanisms.Clinical trials have demonstrated that anti-CD20 monoclonal antibody(Rituximab) is effective and safe to treat refractory RA through depletion of B cells.Rituximab is now approved by FDA for use concurrently with methotrexate to treat RA in patients who have an inadequate response to one or more tumor necrosis factor inhibitors.

ObjectiveTo investigate the diagnostic and prognostic significance of serum human kallikrein11 ( KLK11 ) in patients with ovarian cancer. MethodsThe level of serum KLK11 was determined by enzyme-linked immunoassay(ELISA) for 30 patients with ovarian cancer, 26 patients with benign gynecologic processes and 32 healthy subjects,and the KLK11 value beyond the upper-limit of 95％ credibility interval( 95％ CI) based on the health controls was used as the positive value. The positive rate of KLK11 was compared among the three groups.ResultsThe positive rate of KLK11 in patients with ovarian cancer was significantly higher than those in patients with benign gynecologic processes or in healthy subjects[(73.3％) and(7.7％ ) or(6.3％ ) ,all P ＜0.01 )] ,and there was no significant difference between ovarian benign tumor group and the healthy control group ( P ＞ 0.05 ).ConclusionThe serum KLK11 should be a novel tumor marker in the clinical diagnosis of ovarian cancer.

Focal nodular hyperplasia (FNH) is one of the most common benign liver tumors.It has no potential for malignant transformation and an extremely low rate of rupture or hemorrhage.However,its nature and pathogenesis are still controversial.Accurately diagnosing atypical lesions of FNH based on clinical presentation and radiographic studies are still difficult.This review aims to analyze current literature of FNH and to discuss the new progress of pathologically and clinically relevant advice regarding diagnosis and management.

Objective To investigate the MRI appearances of postpartum posterior reversible encephalopathy syndrome (PRES). Methods The clinical and radiological data of 8 patients with postpartum PRES were analyzed retrospectively, 5 cases were 1 week after postpartum,2 cases were 2 weeks afterpostpartum, 1 case was 4 weeks after postpartum. All cases underwent MRI examination, checking sequence included T,WI,T2WI,FLAIR,DWI,SWI, and 4 of them underwent MR venography (MRV). Results MRI showed basal bilaterally symmetrical distributions of lesions, mainly located in subcortex and cortex of cerebral hemisphere and predominantly in the occipital lobe,the lesions appeared as hyperintensity on FLAIR and T2WI,isointensity or mildly hypointensity on T1WI,hyperintensity on DWI. MRI in 8 patients demonstrated multiple lesions located in bilateral parietal lobe (8 cases),bilateral occipital lobe (8 cases), bilateral frontal lobe ( 4 cases ), bilateral temporal lobe (6 cases ), bilateral tempura-occipital lobe ( 8 cases),splenium of corpus callosum(l case), bilateral basal ganglia (l case), bilateral oval center( 1 case), bilateral cerebellar hemisphere (1 case), left frontal lobe hemorrhage (l case). Five patients' follow-up scan showed decreased or disappeared abnormal signals. Conclusion MRI examination scan identify the location, quality and degree, meanwhile, analyze the pathological foundation of postpartum PRES, which conduces to guiding treatment and preventing complication.

Helicobacter pylori (H.pylori) infection is the most important pathogenic microorganisms associated with the development of chronic gastritis, peptic ulcer and gastric mucosa-associated lymphoid tissue lymphoma (MALT) in children. H.pylori infection may occur in early childhood and last a lifetime even directly affecting the health of adulthood unlessH.pylori infection was eradicated. This article aims to review the infection condition, infection pathway and immunological characteristics ofH.pylori and its relationship with extragastroduodenal diseases in children.

Systemic Sclerosis(SSc) is a fibrotic disease characterized by immunological abnormalities,vascular injury and increased accumulation of extracellular matrix.The etiology has not been fully elucidated yet,so we need to establish a suitable animal model for research.This review is to introduce murine model of bleomycin-induced SSc,and summarize research works on the pathogenesis and treatment of SSc based on this model.