OBJECTIVE:To explore the teaching method for clinical pharmacy undergraduate interns,and provide reference for improving graduation practice effect. METHODS:Starting from the actual teaching work of clinical pharmacy undergraduate in-terns,the teaching work situation was emphatically introduced,development of teaching plan,determinationof teaching duties and development of management practices were described in detail,the working experience and deficiency were summarized,and ap-propriate improvement measures were proposed. RESULTS & CONCLUSIONS:According to the contents and characteristics of clinical pharmacy,teaching plans based on clinical practice was developed for the basic premise of standardization and systematiza-tion by combining with the teaching syllabus;setting up teaching working group,developing management practices for interns and knowing responsibilities of teachers are the fundamental guarantees for successful completion of the internship. Practice has proved that the improvement of the teaching method of teaching was beneficial to improve the effect of clinical pharmacy undergraduates.

Objective: To study the clinical effect of acupuncture combined with methylcobalamin in the treatment of diabetic peripheral neuropathy. Methods: Seventy-five diabetic patients complicated with peripheral neuropathies were included and randomly allocated into a treatment group (40 cases) and a control group (35 cases). The patients in the treatment group all received acupuncture therapy plus methylcobalamin. In the control group, patients only received methylcobalamin for treatment. The therapeutic effect was evaluated 4 weeks later. Results: Both of the two groups presented improvement in nervous symptoms, signs and nerve conduction, and the improvement of the treatment group was significantly better than that of the control group (P<0.05). Conclusion: The therapy of acupuncture in combination with methylcobalamin is more effective than the monotherapy with methylcobalamin in the treatment of diabetic peripheral neuropathy.

Objective To investigate the clinical practice value of transvaginal ultrasound (TVU) combined with hysterosalpinography (HSG) in diagnosis of previous cesarean scar defect (PCSD).Methods Forty-two patients with colporrhagia,algomenorrhea or infertility after cesarean section were examined by TVU,HSG and hysteroscope.The results were compared among TVU,HSG and TVU combined with HSG.Results Among the 42 patients,21 patients were diagnosed PCSD by hysteroscope.The sensitivity of TVU was 66.7％ (14/21),specificity was 95.2％ (20/21),positive predictive value was 14/15,negative predictive value was 74.1％ (20/27).The sensitivity of HSG was 95.2％ (20/21),specificity was 100.0％ (21/21),positive predictive value was 100.0％(20/20),negative predictive value was 95.5％(21/22).The sensitivity of TVU combined with HSG was 95.2％(20/21),the sensitivity of TVU combined with HSG was significantly higher than TVU,there was statistical difference (P ＜0.05).Conclusions Compared with TVU,the sensitivity of TVU combined with HSG is increased markedly.TVU combined with HSG is a feasible clinical diagnostic method.

We studied the biopsies of gastric carcinoma of 460 cases. The ratio of male to female was 2.36 / 1. Most of them were aged 51 to 60 (37.17%). The freouent site was sinuspylorus (46.74%). Low differentiated glandular type was the most prominent (51.52%). Intestinal metaplasia, glandular cyst, and dysplasia of gastric mucosa were found respectively 21.74%, 35% and 32.61%. The observations indicated that incomplete intestinal metaplasia, dysplastic glandular cyst and dysplasia in middle degree, dysplastic glandular cyst and dysplasia in middle degree had intimate relation with gastric carcinoma.

Lupeol,a triterpene,is found in various edible and medicinal plants.Lupeol has been shown to exhibit strong anti-inflammatory,anti-arthritic,gene mutation prevention and anti-malarial effect.Recently,it is found that lupeol is the main active ingredients of inhibiting the growth of a several kinds of cancers and carcinomas in some antineoplastic plants.Lupeol has antineoplastic effect.

Objective To explore the aging characteristics of the gait movement stability of the elderly,so as to provide theoretical guidance for their fall prevention.Methods Fifty-eight elderly participants (ranging in age from 60 to 90) were given the instrumented timed up and go (iTUG) test including walking gait,turning-back and sit-standing using a wearable test system APDM Mobility LabTM (made in USA).Results Significant differences were found in the time of TUG and iTUG between the elderly in their sixties and those no less than 80,as well as between those in the seventies and six-ties;while there were no significant differences between people no less than 80 and those between six-ty and seventy.Moreover,both the above times increased with their age.There were significant differences among the three groups in the step gait parameters including the step length,speed and and several mobile ability indexes (P＜0.05).These parameters showed a tendency of decrease with the increase of the age.There was no significant difference among the three age groups in body-related motion parameters (P＞0.05).However,significant differences were found in turning parameters between people no less than 80 years and 60-70 years age group (P＞0.05),but not between those no less than 80 and those in their sixties (P＜0.05).No significant differences were found in sit-standing parameters,sit-to-stand duration and sit-to-stand range of motion of the trunk among the different age groups (P＞0.05).However,there were significant differences between the elderly no less than 80 and the other two age groups in turn-to-sit peak volecity (TTSPV) and turn-to-sit duration (P＜0.05).Significant differences were also found in the range of motion of the trunk (ROMT) between the elderly aged 60～70 and the other two groups (P＜0.05).The ROMT decreased with the increase of age.Conclusions The gait movement stability of the elderly has obvious aging characteristics and tends to decrease with age,especially in the aspect of longitudinal linear motion control ability.The lateral movement control competency is of weak correlation with age after 70,indicating that the age of 70 may be the critical age of high fall risks.

Measles is an acute respiratory infectious disease caused by measles virus.Measles is highly contagious,and it can spread rapidly mainly in infants and young children.With the application of measles vac-cine,the morbidity and mortality of the disease are significantly reduced,but in recent years,measles is still prev-alent in some regions of our country,and presenting some new characteristics on the epidemiology and clinical manifestations.To understand the present epidemic characteristics and the clinical manifestations of measles in a timely manner,and to monitor the level of the crowd measles antibody plays an important role in achieving the goal of eliminating measles.This article reviews the recent epidemiology and clinical characteristics of measles.

Angiodysplasia ; Child, Preschool ; Humans ; Male ; Pulmonary Artery ; abnormalities ; Pulmonary Veins ; abnormalities

Nano materials are popular with its interesting properties. Large specific surface area, high mechanical strength, good absorbability make them good potencial carriers of catalyst. With the help of chemical modification, nano SiO2 particals were used as carrier to immobilize ?-glucosidase with covalent binding. It is found that the load of nano particals can reach 1/8 of its weight, and the recovered activity of enzyme is 70%. The resistence of immobilized enzyme to organic solvent wase improved obviously, which was then used in Ethyl Acetate-Water-two-phase-system to hydrolyzed soybean isoflavones.