Chronic Disease ; Humans ; Male ; Middle Aged ; Mineral Oil ; adverse effects ; Occupational Exposure ; adverse effects ; Pigmentation Disorders ; chemically induced

OBJECTIVE:To discuss the position and role of hospital in pharmacovigilance.METHODS:The knowledge related to pharmacovigilance was introduced and the status quo and the responsibility assumed by hospital and its stuff in the pharmacovigilance work were analyzed.RESULTS & CONCLUSION:Hospital ought to be one of the main part in the pharmacovigilance,and through training to enhance the knowledge of the doctors,pharmacists and nurses about the pharmacovigilance,so that could build good system for the safety monitoring of drugs,and also could establish rules of pharmacovigilance to reduce ADR,improve rational use of medicine.

The activity of interleukin-2 (IL-2) and expression of interleukin-2 receptor (IL-2 R) were measured in children with acute glomerulonephritis (AGN) in order to detemine the mechanism of the disease Our results showed that the activity of IL-2 in peripheral blood lymphocytes (PBL) of children with AGN was lower than that tof the control group (P

OBJECTIVE:To discuss the role of clinical pharmacists in providing pharmaceutical care in respiratory department.METHODS:The clinical pharmaceutical care provided by clinical pharmacists in respiratory department was analyzed and summarized.RESULTS & CONCLUSION:The pharmaceutical care carried out in respiratory department can help reduce the incidence of medication errors.

Diagnosis, Differential ; Humans ; Pneumoconiosis ; diagnosis

Ech1 is the key enzyme of fatty acid β-oxidation metabolism,and mainly locates in peroxisome and mitochondria.Recent studies indicate that abnormal expression of Ech1 is related with liver carcinoma,stomach carcinoma and chronic lymphoid leukemia,but the mechanism is not very clear.Other members of Echfamily are also closely related to many diseases.

Objective:To establish a ?B2 crystallin gene knockout mice model.Methods: The gene-targeting vector was established by the technique of American inGenious Targeting Laboratory.PCR technique was used to identify the genotype of the model mice and expression of ?B2 crystallin protein was detected by Western blot.Results: Three genotypes were successfully(identified) and expression of ?B2 crystallin protein was not detected in gene knockout mice.Conclusion: The ?B2 crystallin gene knockout mice model has been successfully established.

Thirty five normal esophageal mucosae were observed with electron microscopy. 11 were taken from resected esophageal specimens and 24 were obtained by using fibroendoscope biopsy forceps from normal areas of esophageal mucosae examined endoscopically.Normal esophageal epithelium is divided into basal, prickle and superficial cell layers. The continuous basement membrane separates lamina propria from basal cells. Occasionally a false rupture appears in the obliguely-cut, basement membrane.Intraepithelial lymphocytes and Langerhans cells were found in the basal cell layers and deep in the prickle cell layers. In the cell cytoplasm of one case, a few rod-shaped Langerhans granules with internal periodic substructure were observed. The Langerhans granule measures 250 nm by 50 nm. The results of our observation showed that Langerhans cells were possibly derived from intraepithetial lymphocytes.In the superficial cell layers, a large number of membrane coating granules were identified in pericytoplasm or in the cytoplasmic processes. A few granules were also found in intracellular spaces.Desmosome fields were seen in prickle cell layers. The fields were in the form of labyrinth made up of numerous desmosomes and microvillus processes. No gap junctions were found in the desmosome fields.Twisted thread-like nuclei and indented bizarre nuclei were found in both the prickle cell layers and superficial cell layers. Capillaries with fenestrated endothelium were embedded in the papillae of lamina propria.

Objective:To study the expression and significance of c-myc in pediatric lymph node swollen diseases.Methods:Expression of c-myc gene in swollen lymph node specimens of 84 children with lymph node swollen diseases were determined with SP immunohistochemistry technique.Results:(1)The positivity rates of the c-myc gene of lymphadenitis,reactive hyperplasia (RH) and lymphoma were 15.62%,40.48%,and 80.00%,respectively,and the difference was significant( ? 2=14.59, P

Objective To explore the real burden experience and feelings of the caregivers of patients with advanced pancreatic cancer in the process of care. Methods Totally 9 caregivers of patients with advanced pancreatic cancer were selected and investigated by in-depth interviews. Results Five major themes were found:Psychological burden,Physiological burden,Lack of knowledge, emotion, and economic support system,Challenges to personal life. Conclusions The caregivers of patients with advanced pancreatic bear the burden in Psychology, Physiology and personal life,and lack of emotional, economic and social support to different degrees at the same time. Doctors and nurses should pay attention to the caregivers, help them solve the difficulties, and provide scientific and effective nursing intervention.