Through collecting and sorting of works, literature and medical cases regarding professor ZHANG Tangfa, it is found that his acupuncture academic ideology and clinical treatment of syndrome differentiation can be summarized as: tracing the source and paying attention to basic theory, especially the meridian theory and conception vessel and governor vessel; focusing on acupuncture manipulation and emphasizing acupuncture basic skills; highly valuing treating spirit, acquiring and maintaining needling sensation; underlining "three differentiations" that is consisted of syndrome differentiation, disease differentiation and meridian differentiation to guide the clinical prescriptions of acupoints; exploring and ingenious use of scalp acupuncture; being concerned on research of difficult and complicated diseases; advocating comparative studies to optimize the clinical treatment plan; proposing the combination of Chinese and western medicine, including diagnosis, treatment and basic theory, to improve the clinical therapeutic effects of acupuncture.
Acupuncture ; education ; history ; Acupuncture Points ; Acupuncture Therapy ; history ; methods ; History, 20th Century ; History, 21st Century ; Humans ; Meridians

Objective To observe the clinical efficacy of electroacupuncture in treating functional constipation. Method Sixty patients with functional constipation were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by electroacupuncture, while the control group was by sham-electroacupuncture. The Clinic Constipation Score (CCS), therapeutic efficacy index, plasma NOS, and plasma 5-HT were observed before and after intervention.Result The CCS was changed significantly after intervention in both groups (P<0.05). After intervention, there was a significant difference in comparing the CCS between the two groups (P<0.05). The total effective rate was 93.3% in the treatment group versus 66.7% in the control group, and the difference was statistically significant (P<0.05). The NOS and 5-HT contents were changed significantly after intervention in both groups (P<0.05). After intervention, there were significant differences in comparing the NOS and 5-HT contents between the two groups (P<0.05).Conclusion Electroacupuncture is an effective approach in treating functional constipation, and it can improve NOS and 5-HT contents in gastrointestinal tract.

ObjectiveTo observe the clinical efficacies of electroacupuncture and Prucalopride succinate tablets in treating functional constipation.MethodForty patients were randomized into two groups, 20 cases in each group. The treatment group was intervened by electroacupuncture, and the control group was byoral administration of Prucalopride succinate tablets. The major symptoms scores, stool shape score, serum substance P (SP), and somotostatin (SS) were observed.ResultAfter treatment, there were no significant inter-group differences in comparing the changes of defecation frequency and difficulty scores (P>0.05), while there were significant inter-group differences in comparing the changes of incomplete bowel evacuation sensation, abdominal pain, and stool shape scores (P<0.05); the serum SP and SS levels were significantly changed after treatment in both groups (P<0.05); the total effective rate was 90.0% in the treatment group versus 85.0% in the control group, and the difference was statistically insignificant (P>0.05).ConclusionElectroacupuncture and Prucalopride succinate tablets can produce equivalent efficacies in treating functional constipation, and have their own advantages in improving the relevant symptoms. Therefore, treatment should be chosen according to the disease condition.

The event free survival and overall survival rate of acute lymphoblastic leukemia (ALL)have been improved significantly based on the risk stratify diagnosis and treatment.But there are still some patients suffering therapeutic failure and relapse.With the great development of genome sequencing technology,more and more genetic aberrations behind the refractory and relapse ALL have been identified.Ph-like ALL is charactered with gene expression profile similar to that of BCR-ABL1 positive ALL,involving abnormal activation of cytokine receptor and tyrosine kinase.It has been proved that treatment combined with Tyrosine kinase inhibitors (TKIs) can significantly improve the poor prognosis.Ph-like ALL is one of hot topics during the 56th American Society of Hematology (ASH) annual meeting in 2014.Progression in molecular genetics for Ph-like ALL will be introduced together with the author' s research experience.

Objective To evaluate the sickness impact and the quality of life in patients who received 131 I treatment for Grave's disease with one year of follow-up.Methods 376 patients with Grave's disease(GD) who voluntarily received 131I treatment were recruited.The follow-up archives were established.The Sickness Impact and the Quality of life in patient' s with GD were measured using the Sickness Impact Profile (SIP),Self-Rating Anxiety Scale (SAS),Self-Rating Depression Scale(SAS) and Social Disability Screening Schedule (SDSS) and Quality of life scale(QLS,SF-36) before and after treatment with 131I for 6 months and 12 months.Results 57 out of 376 cases were lost.319 cases finished follow-up studies.There was significant difference of SAS,SDS,SDSS,SIP and SF-36 and their agent score among three groups:before and 6months and 12months after 131I treatment in the 319 patients(F=8.561-1080.317,P＜0.001).After treatment with 131I,SAS,SDS,SDSS and SIP score were lower(P＜0.05),SF-36 total and agent score were higher(P＜0.05).There was no significant difference between the score of SAS,SDS,SDSS,SIP total score and it' s agent score of SD-Ⅱ,SR,W,SF-36 agent score of RP,BP,VT,SF at the end of 12 months compared to the score at the end of 6 months(P＞0.05).But there was significant difference between the score of SIP agent score of SD-Ⅰ,HM,RP,SF-36 total score and it' s agent score of PF,GH,RE,M H at the end of 12 months compared to the score at the end of 6 months (P＜0.05).At the end of 6 months and 12 months after treatment the subjects were divided five groups according to different clinical outcome.Not only at the end of 6 months,but also at the end of 12 months,there was significant difference of SAS,SDS,SDSS,SIP total score,and it' s agent score of SD-Ⅰ,SD-Ⅱ,SR,W,RP,SF-36 total score,and it's agent score PF,RP,BP,GH,VT,SF,RE,MH among the five groups(F6 =6.870-143.790,F12 =13.956-837.184,P＜0.001).There was no significant difference of HM among five groups (F6 =1.733,P6 =0.142; F12 =2.015,P12 =0.092).The score of SF-36 and its agent score PF,RP,VT,SF,RE,MH in three subgroup (healthy control,the patient group at end of 6 months and 12 months with normal thyroid function) was significant different,respectively(F=8.320-82.791,P＜0.001).There was no significant different for agent score of BP and GH(F=2.990,2.652,P=0.051,0.072).Conclusion Quality of life of patients with GD is decrease.131I treatment can improve it,but socialpsycho function can not be improved satisfactorily.It is necessary for GD patients to pay attention to the quality of life and provide effective mental intervention to improve the recovery completely.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Constipation ; physiopathology ; therapy ; Defecation ; Humans ; Male

The integrator complex is multifunctional and contains at least 12 evolutionarily conserved subunits in hu-mans.It interacts with the C-terminal tail of the largest subunit of RNA-polymeraseⅡ ( RNAPⅡ) to promote 3′-end pro-cessing of small nuclear RNA (snRNA) U1/U2.It also interacts with RNAPⅡ, NELF and Spt5 to regulate NELF-mediated RNAPⅡpause/release and processivity at coding genes .Recently, the integrator complex is also reported to be involved in DNA damage response , dynein recruitment to the nuclear envelope , integrity of Cajal bodies , adipose differentiation , hem-atopoiesis , ciliogenesis , tumorigenesis and generation of viral microRNAs .This review discusses related research progress in the integrator complex .

Objective To explore the feasibility of the mixed- or single-application of etomidate and propofol during modified electroconvulsive therapy (MECT). Methods Ninety hospitalized schizophrenics undergoing MECT were randomly assigned to 3 groups which were respectively anesthetized with mixed liquor application of etomidate and propofol (group E-P), etomidate (E) or propofol (P). Charge delivered (CD), EEG seizure duration (ESD), postictal suppression index (PSI), seizure energy index (SEI) and seizure generalization index (SGI) were recorded. Mental status and memory levels were assessed with the Positive and Negative Syndrome Scale (PANSS) and Wechsler Memory Scale (WMS) before and after treatment. The adverse reactions were recorded. All data were analyzed with the software SPSS12.0. Results The ESD, PSI, SEI, SGI and WMS scores, and the minus score of PANSS were significantly higher (P < 0.05) and CD was lower (P < 0.05) in group E-P than those in group P. No significant alteration between group E-P and group E (P > 0.05). The adverse reactions such as nausea/vomiting and secretion increase in group E-P were lower than those in group E (P < 0.05). The injection pain of group E-P was lower than that of group P (P<0.05). Conclusion The mixed liquor of etomidate and propofol has an advantage over the single-application of the two drugs during MECT.

Along with clinical medicine improvement and imageology development, The early diagnosis and treatment of uterine cervical cancer becomes possible. Especially computer tomography(CT) and magnetic resonance imaging(MRI) as well as positron emission tomography/computed tomography(PET/CT) are widespread applied in clinical medicine. These imaging examinational means supply important bases for diagnosis, staging and therapeutic means to uterine cervical cancer.

BACKGROUND:The transplanted tendon must have good biomechanical properties, in order to effectively avoid tendon tear at the anastomosis end during suturing and reduce adhesion of tendon during healing process. OBJECTIVE:To investigate the effects of different methods for preparation of graft materials on the biological properties of tendon al ograft. METHODS:Forty-eight healthy male Leghorns were randomly divided into three groups:vitrification group, chemical extraction group, and control group. Unilateral superficial and deep flexor tendon of the third toe was subjected to vitrification, chemical extraction and no treatment in the three groups, respectively. A part of tendon was taken for biomechanical testing, and the other part was for al ogeneic transplantation. After 1, 2, 3, 6 weeks, peripheral blood CD4+, CD8+T lymphocytes were counted. RESULTS AND CONCLUSION:Vitrification could partial y retain the original tendon cells, but the chemical extraction method could not. Tensile strength for tendon rupture, tensile fracture power and tensile elongation at break were not statistical y significant among three groups (P>0.05). At the end of 1 and 2 weeks after transplantation, CD4+, CD8+, CD4+/CD8+difference was significant among the three groups (P<0.05);at the end of 3 and 6 weeks after transplantation, CD4+, CD8+, CD4+/CD8+were significantly less in the vitrification and chemical extraction groups than the control group (P<0.05), but no difference was found between the vitrification group and chemical extraction group (P>0.05). These findings indicate that the vitrification and chemical extraction methods can significantly reduce immunogenicity of the tendon based on effective retention of biomechanical properties of the tendon.