Kawasaki disease(KD) is the most common reason for acquired heart disease in children,which is closely related to autoimmune response and the release of cytokines in vascular endothelial cells.Steroids are strongly effective in countering inflammation as well as immune response.In the time of being,it has become a hot spot that steroids play an important role in the initial treatment for acute KD and for incomplete and refractory KD.

Kawasaki disease (KD) is one of the most common causes of acquired heart disase in children,the development of which is closely related to the allergic diseases.Recent studies have manifested that the incidence of allergic diseases in children with KD is far higher than that in those children without KD.Meanwhile,the morbidity of KD in allergic children is significantly higher than that in those who do not have family medical history of allergic diseases.By far,the mechanisms causing interaction between KD and allergic diseases still remain unclear.Possible mechanisms include IgE-meditated immune response,release of large quantity of cytokines and inflammatory meditators as well as atopic family history.

Objective To investigate the expressions of tenascin(TN)and microvessel density(MVD) in esophageal squamors cell carcinoma.Methods The experessions of TN and MVD were observed by immunohistochemiccal methods in 91 cases of esophageal carcinoma and 47 cases of ono-esophageal carcinoma.Results ①The expression of tenascin in esophageal cancer was much high than that in t he normal tissue(t=12.331,P＜0.01).②Over expression of TN was related to th length(F=12.373,P＜0.01),the invasion(F=11.039,P＜0.01),the lymphatic metastasis(F=6.882,P=0.01)and the pathologic trade(F=5.060,P=0.003)of cancer.③The expression fo MVD in the esophageal carcinoma tissues was stonger than that in the nonesophageal carcinoma tissues(t=6.023,P＜0.01).④Over expression of NVD wsa related to the length(F=9.033,P＜0.01),the lymphatic metastasis(F=12.429,P＜0.01)and the pathologic grade(F=5.717,P＜0.01)of cancer.⑤The positive expressions of TN and MVD were associated(P=0.001).Conclusion TN;s voerexpressions may be a biological marker in esophageal squamous cell carcinoma..It was associated with the expression of MVD.The levels of TN and NVD were useful molecular markers for evaluating malignancy degree and lymph node metastasis of esopageal carcinoma.

Among esophageal cancer patients who had undergone radical surgery, the overall 5-year survival rate ranges from 20% to 30%. Postoperative radiotherapy is important adjunctive and remedial treatment. However, currently, there is no clear consensus on the indication of postoperative radiotherapy, the optimal radiation fields and dose. We review and summarize the relevant studies for clinical references.

Objective To investigate the impacts of health education on awareness of hyperglycemia,self-efficacy and serum level of blood glucose in patients with coronary heart disease (CHD).Methods Two hundred CHD patients were enrolled in this study and assigned to the normal blood glucose (NGT) group ( n =60),impaired glucose regulation (IGR) group ( n =50),and type 2 diabetes mellitus (T2DM) group (n =90).Health education programme was carried out before and after discharge from the hospital.Fasting plasma glucose (FPG),2 h postprandial blood glucose (2 hPG) and glycosylated hemoglobin ( HbA1c ) of each group were assessed at baseline and 3 or 6 months after the intervention.Chisquare or t test was used for data analysis.Results After the intervention,the awareness of hyperglycemia was significantly improved in each of three groups (NGT group:x2 values were 17.207,23.582,37.046,39.046,38.686,46.218,28.643,39.895,37.046 and 33.333,respectively,all P ＜ 0.05 ; IGR group:x2values were 31.723,23.529,23.389,27.542,21.091,27.307,20.219,38.235,24.669 and 26.475,respectively,all P ＜0.05; T2DM group:x2 values were 21.161,20.680,14.612,23.104,22.383,29.436,19.444,32.526,24.671 and 31.696,respectively,all P ＜ 0.05 ).Self-efficacy scores of symptom selfmanagement and common disease management were increased after the health education intervention (t values were 12.75 and 7.21,respectively,both P ＜ 0.05 ).At 3 or 6 months,the NGT group showed on significant change in FPG,2 h PG and HbAlc (F values were 2.35,1.97 and 2.01,respectively,all P ＞0.05) ; however,FPG,2 h PG and HbAlc of the IGR and T2DM group were significantly decreased ( IGRgroup:F values were 8.07,8.89,and 10.23,respectively,all P ＜ 0.05 ; T2DM group:F values were 12.35,11.56 and 8.99,respectively,all P ＜ 0.05 ).Conclusion Health education could improve the awareness of hyperglycemia,self-efficacy and glucose metabolism in patients with CHD.

Objective To study the clinical characteristics of Henoch-Sch(o)nlein purpura (HSP) in children.Methods We retrospectively analyzed the clinical data of 124 children with HSP.Results Among these 124 children,54.84% of the children presented upper respiratory tract infection before the onset of HSP.The purpura recurred in 30 of 47 children with Henoch-Sch(o)nlein purpura nephritis and in 22 of 77 children without Henoch-Schonlein purpura nephritis,respectively (P＜0.05).The incidence of Henoch-Sch(o)nlein purpura nephritis was significantly higher in children who had purpura,gastrointestinal symptoms,and joint symptoms simultaneously than in those only with purpura (P＜0.05).The elevated levels of IgA and C reactive protein were found in 67.35% and 39.39% of the children,respectively.Conclusion The most important predisposing factor of HSP is upper respiratory tract infection.The children with recurrence of purpura or those who have purpura,gastrointestinal symptoms,and joint symptoms simultaneously are more likely to present renal damage.

The multiplex gene expression genetic analysis system is a novel analytical platform,characterized by its primer design with gene-specific and universal sequences.The fluorescence capillary electrophoretic separation is used to compare and analyze the expression levels of multiplex PCR products.This technology is simple,rapid,productive and cost-effective,and holds great promise for cancer classification and biomarkers discovery.

Objective:To investigate the epidemic features of allergic rhinitis(AR)and correlative risk factors in Shihezi city,Xinjiang province,China. Method:A question-naire survey on AR and airway diseases was conducted among 2300 elementry school children in 12 schools,aged from 9 to 10 years old,from july 10 to 25,2008. in Shihezi city,Xinjiang province.Suspects of AR was identified by the survey,then they were recommended to specialist examinations for accurate diagnosis. Allergen skin tests were peformed to explore the allergenic varieties of allergic rhinitis. Diagnosis criteria of AR were that of ARIA(Allergic rhinitis and its impact on asthma). Resuit:Two thousand two hundred and eleven questionnaires were returned. The response rate was 96.1% and 2205 questionnaires were available.The prevalence rate of AR in children aged from 9 to 10 was 12.56%(277/2205) in Shihezi city.The difference of prevalence between female 13.76%(153/1112) and male 11.34%(124/1093) was insignificant statistically(χ~2=2.924,P＞0.05). The positive rate of the allergen skin test was 65.3%. The most common allergen of allergic rhinitis were plants of the mugwort and house dust mite. According to the ciassification criteria of ARIA in 2001,of 155 children suffered from intermittent AR,112 cases were mild and 43 cases were moderate-severe,while 122 suffered from persistent AR,110 cases were mild and 12 cases were moderatesevere. 5.4%(15/277) patients with AR also had bronchial asthma.25.3%(70/277) of the children with AR had inherent predisposition.Conclusion:The prevalence rate of AR in children aged from 9 to 10 in Shihezi city is 12.56%. Strategy of prevention and treatment of AR can be worked out according to the epidemical feature of AR.

Objective To analyse clinical and imaging characteristics of congenital airway abnormalities,and to guide the clinical diagnosis and reduce rate of missed diagnosis and misdiagnosis.Methods Clinical and imaging characteristics in children who had been diagnosed congenital airway abnormalities in Shengjing Hospital of China Medical University from 2005 to 2011 were reviewed and analysed retrospectively.Results Of 23 children,12 cases were male,11 cases were female,the age was from 1 month to 10 years,the average age was 32 months.The disease course was from 3 days to 3 months,an average was 18 days.Clinical manifestations were repeated coughing,wheezing,dyspnea and recurrent respiratory infection.Through the spiral CT and three dimensional reconstruction,enhanced CT examination,6 cases of tracheobronchial stenosis,3 cases of trachea and bronchus,1 case of dysplasia of the left pulmonary artery and vein,3 cases of pulmonary sequestration,4 cases of pulmonary cyst and 6 cases of pulmonary hypoplasia were found.Conclusion Missed diagnosis and misdiagnosis of congenital airway malformations often occurs.When the following features were observed,congenital airway malformations may be taken into account:persistent cough; repeated or persistent wheezing,treated ineffectively with anti-inflammatory agent and bronchodilators ; recurrent or persistent stridor; repeated pulmonary infections,dyspnea; repeated or persistent pneumonia in the same part and unexplainedly mediastinal shift in X ray chest radiography.Spiral CT three dimensional reconstruction and enhancement is of great value in diagnosis of airway malformation.

Curcumin can induce cell apoptosis in human chondrosarcoma cells through extrinsic death receptor pathway,inhibit proliferation of lung cancer cells by inducing cell cycle arrest,and can suppress proliferation and induce apoptosis in cholangiocarcinoma cells through blocking multiple signaling pathways,suppress the formation of tumor blood vessels by reducing the expression of vascular endothelial growth factor in Ehrlich ascites cancer cells,inhibit breast cancer cell motility and invasiveness by regulating the expression of adhesion molecules and increase the sensitivity of chemotherapy drugs to cancer cells by regulating the expression of multidrug resistance related genes.Curcumin has explored new approaches for the treatment of tumor.