Objective To discuss the treatment of cervical cancer in different stages.Methods The treat- ment of 42 cases of cervical cancer in this hospital from January 2000 to December 2005 was analysed,and clinical treatment modalities were analysed too.Results(1)A total of 6 cases of uterine carcinoma in situ received hysterec- tomy plus bilateral salpingo-oophorectomy.(2)A total of 26 cases was inⅠb-Ⅱa stage,of which 15 cases with cer- vical cancer were treated with a simple radical hysterectomy;6 cases of cervical cancer were radiotherapied after radi- cal hysterectomy;7 cases of cervical cancer received radical hysterectomy plus radiotherapy.(3)A total of 10ⅡbⅣstage eases selected radiotherapy and chemotherapy.Conclusion Different treatment should be applied in differ- ent stages of cervical cancer,and the choice for treatment is important for patients' quality of life after treatment. Comprehensive treatment can improve the survival of patients with cervical carcinoma.

Objective To propose a new classification scheme of otitis media (OM). Methods By reviewing current internat ional classification systems of OM, we analyzed their disadvantages and the prog ress made in histopathologic studies of OM, then worked out a new classification scheme to apply it to clinic. Results In current internati onal classification systems of OM, those apparent clinical signs are regarded as main standards of classification. Their main disadvantage is that these signs c annot very well indicate the condition of pathologic and functional changes of i mportant hearing structure areas. We proposed a “Three-stage Scheme” of OM cl assification and applied in 1 160 cases of OM. The accuracy rate of diagnosis w as 82.4% in 348 cases of early-stage OM, 98.4% in 696 cases of chronic OM, and 95.2% in 116 cases of OM sequela. Conclusion The “Three-s tage Scheme” system is scientific, simple and practical. Its accuracy rate of d iagnosis is very high. It plays a guiding role in diagnosis and treatment of OM.

Selective COX-2 inhibitors can promote the apoptosis of tumor cells and block the growth of new blood vessels through the inhibition of ring oxidase,vascular endothelial growth factor,microvessel and so on. Research shows that COX-2 is overexpressed in vascular and endothelial cells of lung cancer,select COX-2 inhibitors to adjuvant chemotherapy,not only can directly inhibit the tumor proliferation,but also can reduce the adverse reaction of chemotherapy drugs,and enhance the curative effect. To investigate the effects of selec-tive COX-2 inhibitors and cisplatin in lung cancer angiogenesis and its mechanism,will be a hope for the clini-cal treatment of tumor.

COX-2 is the inducible form of cyclooxygenase,which is overexpressed in non-small cell lung cancer,especially in the adenocarcinoma,and is involved in the production of lung cancer drug resistance, reducing the sensitivities of tumor cells to chemotherapy drugs. COX-2 inhibitors have the effects of antitumor and prevention of tumor formation. Therefore,in order to reverse the drug resistance of tumor cells,improve the sur-vival rate and the prognosis of patients with tumor,the application of COX-2 inhibitors as adjuvant chemotherapy and combined with chemotherapy drugs has become a new direction in the treatment of lung cancer.

Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Nasal Septum ; pathology ; Nose Neoplasms

Objective To compare therapeutic effect of single hemoperfusion and hemoperfusion combined with continuous veno-venous hemofiltration ( sequential continuous blood purification) on patients with severe acute organophosphate poisoning combined with myocardial injury.Methods A total of 80 patients with severe acute organophosphate poisoning combined with myocardial injury admitted to EICU of Beijing Chaoyang Hospital from Jan.2004 to Dec.2013 were respectively analyzed and divided into two groups: hemoperfusion group (patients collected from Jan.2004 to Dec.2008, n=41) and sequential continuous blood purification (patients collected from Jan.2009 to Dec.2013, n =39).The average cholinesterase recovery time, the average consciousness recovery time, the average doses of atropine, the average hospital time, the change of cardiac troponin I levels on days 1, 2, 3, 5 and 7 after admission, and the change of left ventricular ejection fraction within 24 h after admission and after 24 h following blood purification treatment were compared between the two groups.Results Patients in the sequential continuous blood purification group had less average cholinesterase recovery time, average consciousness recovery time, average doses of atropine and average hospital time compared with patients in the hemoperfusion group [ ( 87.6 ±8.8 ) h vs.( 113.8 ±13.3 ) h;(57.3 ±11.7) h vs.(100.5 ±10.8) h;(284.5 ±61.4) mg vs.(476.6 ±93.1) mg and (10.2 ±2.3) vs. (14.6 ±3.9) , all P<0.01].The levels of cardiac troponin I on days 2, 3, 5 and 7, and ejection fraction of left ventricule after 24 h following blood purification treatment in the sequential continuous blood purification group were significantly decreased compared with patients in the hemoperfusion group ( all P <0.05 ) . Conclusion Therapeutic effect of sequential continuous blood purification on patients with severe acute organophosphate poisoning combined with myocardial injury is superior to single hemoperfusion.It suggests that sequential continuous blood purification could be used as a preferred choice in treatment of patients with severe acute organophosphate poisoning combined with myocardial injury.

Objective To investigate and analyze the relative factors in elderly men with type 2 diabetes mellitus(T2DM)complicated with osteoporosis(OP),thus to provide guidance for prevention of OP complicated with T2DM in elderly men.Methods Dual X -ray absorptiometry determination of bone mineral density (BMD)of 67 cases of elderly men with diabetes,men were divided into OP group (n =32),NOP group (n =35).Then,we compared differences in body mass index(BMI),diabetes duration,fasting plasma glucose (FPG),glycosylated hemo-globin(HbA1c),patients'age,fasting insulin(FINS),insulin sensitivity index(ISI),quantitative of urinary albumin (ALb),quantitative of urinary protein in 24 hours and alkaliphosphatase level(ALP),low density lipoprotein choles-terin(LDL -C),triglyceride(TG),and made correlation analysis.Results Compared with those in NOP group,pa-tients in OP group had older age,longer disease course,smaller baric index,lower BMD,higher ALP,lower FINS,low-er ISI,higher HbA1c,higher quantitative of urinary protein in 24 hours and urinary albumin,higher LDL -C,which were significantly different (P <0.05);BMD of elderly men with T2DM was negatively correlated to patients'age, disease course,HbA1c,quantitative of urinary protein in 24 hours,ALb,ALP and LDL -C,but positively correlated to BMI,FINS and ISI.Conclusion Many factors,such as elderly,low body weight,long duration of the disease,high level of blood sugar,insulin dysfunction,low insulin sensitivity,high level of blood suger,insulin dysfunction,low insulin sensitivity,high serum alkalinephosphatase,high LDL -C and diabetic nephropathy,contribute to osteoporosis in elderly men with T2DM.

Objective:To study influence of type 2 diabetes mellitus (T2DM) on ambulatory blood pressure (ABP) levels and blood pressure variability (BPV) in aged patients with essential hypertension (EH) .Methods:A total of 80 aged EH +T2DM patients treated in our hospital from Jun 2014 to Jan 2016 were selected as observation group ,another 80 aged pure EH patients were selected as EH control group .The 24hABP indexes and BPV indexes were compared between two groups . Results:Compared with EH control group , there were significant rise in 24h mean systolic blood pressure [24hSBP , (126.47 ± 9.64) mmHg vs .(134.98 ± 10.63) mmHg] ,nighttime mean SBP [nSBP ,(125.73 ± 10.19) mmHg vs .(133.74 ± 11.29) mmHg] ,daytime mean SBP [dSBP ,(128.29 ± 10.97) mmHg vs .(136.42 ± 12.18) mmHg] ,daytime mean pulse pressure [dPP ,(59.46 ± 10.79) mmHg vs .(65.38 ± 11.69) mmHg] ,nPP [ (58.00 ± 10.11) mmHg vs .(67.14 ± 9.93) mmHg] and 24hPP [ (59.27 ± 10.16) mmHg vs .(64.76 ± 11.62) mmHg] , P<0.01 all;and significant rise in 24hSBP standard deviation [24hSBPSD ,(12.63 ± 2.87) mmHg vs .(18.41 ± 3.09) mmHg] and nSBPSD [ (10.14 ± 3.53) mmHg vs .(14.89 ± 3.54) mmHg] in observation group , P<0.01 both .Conclusion:Diabetes mellitus elevates daytime and nighttime SBP ,increases BPV and risk of cardiovascular diseases in aged EH patients .

Objective To analyze the relevance between the nursing students′ sense of life meaning and death attitudes. Methods 181 nursing students were surveyed with the Purpose In Life Test (PIL) and Death Attitude Profile-Revised (DAP-R), and then did the relevant statistical analysis. Results The nursing undergraduates′overall average of PIL was (91.45 ± 10.54) points, and the neutral acceptance death attitude got the highest scores which were 24.14 ± 5.78, while escape acceptance got the lowest scores which were 11.76 ± 3.61. And there was a significant negative correlation (r =-0.257, P <0.05) between the sense of life meaning and death attitudes. Conclusions There was a significant negative correlation between the sense of life meaning and death attitudes, the more sense of life meaning was, the more positive attitudes toward death would be. So it′s of great importance to provide life-and-death education to improve the nursing students′sense of life meaning and death attitudes.

Objective To evaluate the clinical value of dual-energy subtraction digital radiography in diagnosing the pulmonary nodulesand calification in nodules.Methods Using American GE Revolutln DR-XR systems,All 80 patients were examined by dual-energy.Tissus images、bone images and the original digital radiographic images were obtained.Dual-energy digital subtraction images were compared with the original digital radiographic images.Results Of 186 pulmonary nodules proved by CT,126(94 uncalified and 32 calified)were detected by tissues images and bone images and 109(83 uncalified and 26 calified)were detected by the original digital radiographic images.Conclusion Dual-energy subtraction imaging is superior to the original digital radiographic images in detection of pulmonary nodules and calification in a nodule.Dual-energy subtraction images can act as a complement for the original digital radiographic images.