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OBJECTIVETo study the cranial-cervical lymph return and pathway in rabbit in order to provide the experimental and theoretical basis for the study of intracranial metastasis of cervical tumor and extracranial metastasis of intracranial tumor.

METHODThe distribution and clearance of tracers were observed after microinjection of lymph developer labeled by 99mTc into cerebral cortex and deep cervical lymph nodes of rabbit.

RESULTSIn the cerebral cortex microinjection with 99=Tc-labeled lymph developer group, the radioactivity were detected in Willis artery, deep cervical lymph nodes and venous blood. The radioactivity curve was the same in Willis artery and deep cervical lymph nodes. The peak in the artery blood was higher than that in venous blood. In the lymph nodes microinjection with 99mTc-labeled lymph developer cervical group, the radioactivity were detected in skull base dura mater, brain, cerebrospinal fluid and venous blood. The peak in skull base dura mater showed earlier than that in cerebrospinal fluid and brain. The peak in venous blood was the last, but the radioactivity in it was the highest.

CONCLUSIONThe cranial-cervical lymph return in rabbit is existent. Their pathway perhaps is Willis artery, skull base dura mater and cerebrospinal fluid circulation.

Animals ; Lymph ; diagnostic imaging ; metabolism ; Lymph Nodes ; diagnostic imaging ; metabolism ; Lymphatic System ; metabolism ; Lymphatic Vessels ; diagnostic imaging ; metabolism ; Lymphoscintigraphy ; Male ; Organotechnetium Compounds ; Rabbits

8.The advances of molecular pathology of follicular thyroid carcinoma.

Yang ZHAN ; Quan-Cai CUI

Chinese Journal of Pathology 2004;33(3):268-270

9.Serum malondialdehyde level and activities of antioxidant enzymes of children from Kaschin-Beck disease areas of Xinghai county in Qinhai province

Wei, WANG ; Zhi-lun, WANG ; Jing-hong, CHEN ; Bo-quan, YU ; Zhan-tian, YANG ; Tian-you, MA

Chinese Journal of Endemiology 2012;31(1):51-54

Objective To observe the activities of serum peroxidase capacity,and lipid peroxidation of children from Kaschin-Beck disease (KBD) areas of Xinghai county in Qinhai province,and to explore the relationship between antioxidant capacity and KBD.Methods Sixty four KBD and forty six health subjects without KBD were chosen from KBD endemic areas,which included primary schools of Tangnaihai,Xialujuan and Qushian of Xinghai county in Qinghai province,and fifty nine age-matched healthy control subjects without KBD were from a non-KBD endemic area,Nanfan primary school of Chang'an county in Shaanxi province.Twenty patients with KBD and twenty control subjects from KBD areas and non-KBD area were extracted by simple random sampling method.2,3-DAN fluorescence technique was used to test the hair and blood selenium.The biochemical techniques were used to test the indicators of oxidative stress including malondialdehyde(MDA),antioxidant enzyme activities,total antioxidant capacity(T-AOC),serum superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GSHPx).ResultsAll patients with KBD had significantly lower serum GSH-Px activities[ (59.53 ± 25.23)kU/L] and selenium levels in hair[ (67.64 ± 17.28)μg/L] and blood[(36.27 ± 13.29)μg/L],respectively,than that of control subjects from KBD areas [ ( 91.88 ± 22.99 ) kU/L,( 153.32 ± 24.31 ) μg/L,( 63.06 ± 13.66) μg/L ] and nonKBD areas[ ( 122.68 ± 41.74)kU/L,(242.35 ± 38.56)μg/L,(98.93 ± 17.18)μg/L,all P ＜ 0.05].Serum MDA levels in KBD patients[ (4.64 ± 1.11 )μmol/L] were significantly higher than that in control subjects from KBD [(3.31 ± 1.22)μmol/L] and non-KBD areas[ (3.43 ± 1.29)μmol/L,all P ＜ 0.05].On the other hand,T-AOC,SOD and CAT activities were significantly higher in both KBD[(19.80 ± 6.64),(55.80 ± 8.14),(16.45 ± 5.61 ) kU/L] and control subjects[ (21.71 ± 8.82),(57.45 ± 6.96),(15.63 ± 9.18)kU/L] from KBD areas than that of control subjects from non-KBD area[ (13.56 ± 5.38),(42.79 ± 8.10),(6.05 ± 2.71 )kU/L,all P ＜ 0.05 ].Hair selenium levels,blood selenium levels and GSH-Px activity of control subjects from KBD areas were,respectively,significantly lower than that in control subjects from non-KBD area(all P ＜ 0.05).Conclusions These findings strongly confirm the evidence that KBD patients are susceptible to oxidative stress.The results also show the increase in antioxidant enzymes,which could probably be due to adaptive response to pro-oxidant in KBD state.Hence,there seems to be an imbalance between oxidant and antioxidant systems in KBD patients.

10.Surgical treatment of transclavicular and transsternal tumor.

Dong-Dong ZHU ; Zhan-Quan YANG

Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2006;41(11):848-850

1.Telomeric loss and anaphase chromosomal bridge in laryngeal squamous cell carcinomas.

2.Studies on Bcl-xl, Bax and Bid expressions and erythroblasts apoptosis in chronic altitude sickness.

3.Traumatic bleeding vertebra contrary: report of 2 cases.

4.Anterior intercavernous sinuses injured in transsphenoidal surgical for pituitary adenomas.

5.Primary malignant lymphoma of the larynx: a report of two cases.

6.Radioisotopic measurement of mucociliary transport rate in nasal middle meatus of healthy people.

7.Experimental study of cranial-cervical lymph return in rabbit.

8.The advances of molecular pathology of follicular thyroid carcinoma.

9.Serum malondialdehyde level and activities of antioxidant enzymes of children from Kaschin-Beck disease areas of Xinghai county in Qinhai province

10.Surgical treatment of transclavicular and transsternal tumor.

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