Acute Disease ; Adolescent ; Adult ; Aged ; Ammonia ; poisoning ; China ; Environmental Exposure ; adverse effects ; Female ; Gas Poisoning ; etiology ; therapy ; Humans ; Male ; Middle Aged ; Prognosis ; Pulmonary Edema ; etiology ; therapy ; Respiratory Distress Syndrome, Adult ; etiology ; therapy ; Treatment Outcome

Six new bisabolane-type phenolic sesquiterpenoids, including plakordiols A-D (1-4), (7R, 10R)-hydroxycurcudiol (5) and (7R, 10S)-hydroxycurcudiol (6) were isolated from the marine sponge Plakortis simplex collected from the South China Sea. Their structures were determined based on extensive analysis of spectroscopic data. Their configurations were assigned by coupling constant analysis, NOESY correlations, and the modified Mosher's method. Furthermore, their cytotoxic and antibacterial activities were evaluated.
Animals ; Anti-Bacterial Agents/pharmacology* ; China ; Molecular Structure ; Monocyclic Sesquiterpenes/pharmacology* ; Pacific Ocean ; Plakortis/chemistry*