Objective To study the efficacy and safety of lamivudine in treatment of chronic hepatitis B with pregnancy. Methods 42 women with chronic hepatitis B in front of and during pregnancy were treated by lamivudine 100 mg once daily. The efficacy of antiviral therapy,mothers or their infants complications,the risk of perinatal transmission of HBV infection were observed. Results In lamivudine-treated group, serum HBV-DNA was not detected in 85.71%(36/42). Normalization of liver function was achieved in 88. 10% (37/42). Severe hepatitis B was not oc-cured,the rates of mothers or their infants complications and HBV perinatal transmission were also decreased obviously. Compared with control group,the differences were statistically significant(P <0. 05). Conclusions Lamivudine in the treatment of chronic hepatitis B during pregnancy was safe and effective,and conduced to improve the curative effect in treatment of chronic hepatitis B, and reduced mothers or their infants complications and HBV perinatal transmission.

Aim To investigate the effects of isoliquiritigenin(ISL) on cognition dysfunction and brain energy metabolism following repeated cerebral ischemia-reperfusion in mice.Methods Mouse models of learning and memory deficits were made by repeated occlusion of bilateral common carotid arteries and reperfusion. Step-down test and Y-maze task were used to examine the learning and memory abilities of mice. The brain energy state was analyzed by reversed-phase high performance liquid chromatogra phy. Results ISL 10, 20 and 40 mg?kg -1 ig reduced the n umber of errors and extended the latency of memory in step-down test, decreased the number of cumulated stimulation and increased the number of right choices i n Y-maze task. ISL(10, 20, 40 mg?kg -1) increased the levels of ATP, ener gy charge (EC) and total adenine nucleotides(TAN) in a dose-dependent manner. Conclusion The results suggest that ISL improves cognition dysfun ction induced by repeated cerebral ischemia-reperfusion in mice, which may be r elated to the improvement of brain energy metabolism.

Objective To discuss the effect of psychological intervention combined with aspirin on the quality of life in patients with acute myocardial infarction (AMI) and surgical treatment of acute myocardial infarction (AMI).Methods 78 patients with acute myocardial infarction undergoing operation in our hospital from January 2015 to June 2016 were randomly divided into experimental group and control group,39 cases in each groups.The control group was treated with clopidogrel and aspirin.The experimental group was treated with aspirin and aspirin and psychological intervention.The therapeutic effects of the two groups were compared and analyzed.Results The experimental group ECGST recovery rate was 82.05%, the pain relief rate was 94.87%, chest X-ray improvement rate was 71.79%, the control group of ECGST segment recovery rate was 61.53%, the pain relief rate was 71.79%, chest X-ray improvement rate was 48.71%, the recovery rate of clinical symptoms of the experimental group was significantly higher than the control group, with statistical significance the difference between the two groups (P<0.05);the quality of life of the experimental group was significantly better than the control group, with significant difference between two groups (P<0.05), experimental group after treatment, mean platelet volume and platelet count before treatment was significantly better than before treatment, the difference was statistically significant(P<0.05).Conclusion In patients with myocardial infarction treated with aspirin and ticagrelor and psychological nursing, found that patients with symptoms change obviously, and the quality of life has improved, is conducive to the recovery of patients, worthy of clinical popularization and application.

Objective To evaluate the efficacy of laparoscopic operations in the treatment of ectopic pregnancy.Methods A total of 148 cases of tubal pregnancy from January 2002 to January 2005 were studied.Laparoscopic operations included 106 cases of oviduct-sparing operation(79 cases of oviduct fenestration and 27 cases of lesion clearance),37 cases of salpingectomy,and 5 cases of lesion clearance.Results The diagnosis and operation were laparoscopically completed in all the 148 cases.Persistent ectopic pregnancy occurred in 2 cases.Postoperative monitoring of serum ?-hCG levels showed the shortest recovery time to normal levels after the treatment of salpingectomy(8?1 d),and the longest one after lesion clearance (15?2 d).Regular menstruation resumed at((31?)2 d) after salpingectomy and at(43?3 d) after lesion clearance.Follow-up checkups with uterotubography in 84 cases for 1~3 months(mean,2.3 months) found a patent rate of both oviducts of 82.1%(69/84).Conclusions Laparoscopic operations is a safe and effective option in the treatment of ectopic pregnancy.

Objective To explore the feasibility of laparoscopic subtotal cholecystectomy without using titanium clips.Methods Laparoscopic subtotal cholecystectomy was performed without using titanium clips on 48 patients,who had serious adhesions at the Calot's triangle.The cystic duct was ligated by silk.Results The operations were completed uneventfully in all the cases without converting to open surgery.No massive hemorrhage or biliary leakage occurred during the operation.The patients were followed up for 3 months to 3 years(mean,18 months),during which no one developed abdominal pain,fever,or jaundice.Conclusions Laparoscopic subtotal cholecystectomy without using titanium clips is a safe and simple method for patients with serious adhesions at the Calot's triangle.The rate of postoperative complications is low.

Based on the comparison of medical humanistic education among The Mainland,Hong Kong and Taiwan,this article arrives at the conclusion that the gap in the field of humanity education in the Mainland is one of the important reasons that cause the ever-tenser physician-patient relationship in nowadays.So we propose the countermeasures actively.By increasing the humanity courses,changing the teaching method,reinforcing the construction of talented staff in humanity,creating the environment for the humanity education and so on,we reinforce humanity quality of medical students in order to improve our medical education.

AIM: The aim of this investigation was to confirm the best operation conditions in the membrane separation of protein from the homogenate of red earthworm, Eisenia faefida. METHODS: Ultrafiltration membrane of fresh red earthworm with the cut-off of 10 000 was used as the target process, with the homogenate flux as index, the best value of operation parameters such as pressure、 temperature, surface rotation speed and feed concentration were fixed on. RESULTS: (1) The best suitable operation conditions were 0.25 MPa, 30?C , 200 r/min, pH=6.7, 33.3% (w:w) concentration and not a bit of NaCl. (2) The molecular weight distribution of protein in the homogenate of red earthworm mainly lay between 50 000～100 000. CONCLUSION: The obtained experimental results will provide pilot scale test with data support.

Objective To explore the character of the myelodysplastic syndrome(MDS) with autoimmune disorders (AID).Methods The clinical data of 60 MDS patients were reviewed.Results 5 of 60 MDS patients had AID ,of which 3 had Graves' disease.The commonest MDS was refractory anemia with ringed sideroblasts (RAS).Conclusion MDS might occur with Graves' disease.Humoral immunological abnormality might play an important role in MDS patients with autoimmune disorders and FAB types might not be associated with this.

Objective To find out the defects existing in the rinsing and sterilizing process of the automatic bottle washer and to put forward an improvement measure and efficiency assessment.Methods To make the washer more effective,an automatic brush pre-washing process and a rotary spraying device were designed and used.The total bacteria amount,the total coliform group and the disinfectant (ClO2) residual level were employed as the assessment parameters.Results An external automatic pre-washing machine was installed on the bottle washer;the bottle washer was innovated so that its spray nozzle could be in directions and the rinsing and sterilizing process could be enhanced.The results showed that the improved machine ran well in treating the polluted and recycled bottles and all the assessment indexes were better than that of before improvement.Conclusion The improved automatic bottle washer is considered effective in cleanout and sterilization of bottles with a satisfactory result.