Objective To analyze the clinicopathologic features,diagnosis and different diagnosis of solid papillary carcinoma (SPC) of the breast.Methods The clinical data and pathological section,including HE and immunohistochemical staining slice,of 12 cases of SPC in People's Hospital of Shanxi Province from December 2008 to August 2014 were analyzed.Simultaneously,a literature search was conducted by utilizing Pub Med for all reported cases in English from November 1995 to October 2014.Results All cases were female,aged from 50 to 77 years old,manifested as mass or nipple discharge.Histologically,all cases appeared as multiple,well-circumscribed nodules filled by monotonous,low-moderate grade cell separated by fibrovascular cores.Immunohistochemically,CgA,Syn,ER and PR were positive in 12,11,9 and 5 cases,respectively.Her-2 presented as 1+ in 1 case (1/12) with invasive mucinous carcinoma,and locally poor positive in 2 cases without invasive component,while CK5/6 was negative in all cases.p63 and CK5/6 were positive in 6 and 5 cases at the location of axis of papillary,respectively.Meanwhile,8 and 7 cases at the border of duct,respectively.Conclusion SPC is an uncommon breast tumor,which presents with specific clinicopathologic features.

Objective To investigate the clinical value of 6‐indicator of albumin ,alpha 1 globulin ,alpha 2 globulin ,beta 1 globu‐lin ,beta 2 globulin and gamma globulin detected by the automatic capillary serum protein electrophoresis in liver cancer disease . Methods Eighty‐three hospitalized patients(51 cases of primary liver cancer and 32 cases of secondary liver cancer) in our hospital from December 2014 to November 2015 were collected .The automatic biochemical analyzer and automatic capillary serum protein e‐lectrophoresis was adopted to detect the 8 indicators of serum albumin(g/L for quantitative indicator and % for qualitative indica‐tor) ,total protein ,alpha 1 globulin ,alpha 2 globulin ,beta 1 globulin ,beta 2 globulin ,gamma globulin .And 100 individuals undergo‐ing the healthy physical examination were randomly extracted as the control group .The levels of above 8 indicators were compared among various groups .Results The level of albumin(% ) and gamma globulin had statistical difference between the primary liver cancer group before treatment and the control group(P<0 .05);the levels of albumin(g/L) ,albumin(% ) ,beta 1 globulin and gam‐ma globulin had statistical difference between the primary liver cancer group after treatment and the control group(P<0 .05);the levels of albumin(g/L) and albumin(% ) after treatment in the primary liver cancer group were decreased compared with before treatment ,the difference was statistical difference(P<0 .05);the sensitivity and specificity of gamma globulin for indicating primary liver cancer were significantly higher than those of the other three indicators;at the same time in the comparison of the positive rate of serum gamma globulin ,the positive rate of serum gamma globulin in the primary liver cancer group was higher than that in the secondary liver cancer group and the control group(P<0 .05) .Conclusion The automatic capillary serum protein electrophoresis detection finds that gamma globulin has some clinical value in the diagnosis and treatment of liver cancer .

Objective To determ inate triptolide and wilforlide A in biological sam ples by liquid chrom atog-raphy-tandemmass spectrom etry (LC-M S/MS)method and to verify themethod. Methods A fter 0.4mLblood, urine or 0.4 g hepatic tissues with internal standard were extracted by ethyl acetate, they were separated on a A llure PFP Propyl (100mm ×2.1mm , 5μm ) with amobile phase ofmethanol-20mm ol/Lammonium acetate using gradient elution. Formass spectrom etric detection, electrospray ionization (E SI+) in positivemode was elected and the data was collected usingmultiple-reactionmonitoring (M R M ). Results The linearity was good (r>0.995 0) and the lim it of detection was 2 ng/m Lor 2 ng/g for triptolide and wilforlide A . The recovery was 61.08% -102.98% . The intra-day and inter-day precision was less than 12.58% for each biological sam ple, and the accuracy was 90.61%-105.80%. Conclusion Thismethod is sim ple, convenient and good selective, and could be applied to analysis of triptolide and wilforlide A in different biological sam ples. A nd themethodmay provide technical support for forensicmedicine identification, clinical diagnosis and treatm ent of tripterygium wilfordii Hook. f. poisoning.

Objective To investigate the relationship of the location of nerve compression and different type of trigeminal neuralgia.Methods Twenty-one patients with typical trigeminal neuralgia and 16 patients with atypical trigeminal neuralgia were treated by micro-vascular decompression.The position of the responsible vessels was probed during operation.Results Compared with atypical trigeminal neuralgia group, the compression rate of trigeminal root entry/exit zone (REZ) in typical trigeminal neuralgia group was significantly higher(P<0.01).The compression rate of trigeminal REZ which oppressed by artery in typical trigeminal neuralgia group was significantly higher than that in atypical trigeminal neuralgia group ( P<0.01 ) .Conclusions The responsible vessels in typical trigeminal neuralgia patients is mostly located in the trigeminal REZ, and the responsible vessels is mostly not located in other location in the trigeminal REZ.The responsible vessels oppress REZ is closely related to types of trigeminal neuralgia.

ObjectiveTo observe the effects of the Partner Rehabilitation Gymnastics on periarthritis of shoulder in later stage. MethodsPatients were randomly divided into 2 groups: 60 in treatment group accepted the Partner Rehabilitation Gymnastics, and the other 60 accepted the forcing active and passive physiotherapy.Results76.66% of the treatment group recovered, 96.66% improved; while 45% of the control group recovered, 73.33% improved. The scores of visual analogous scale and activity of daily living improved after treatment in both groups, and the differences pre- and post-treatment were more in treatment group than in control group. ConclusionThe Partner Rehabilitation Gymnastics is more effective than the routine forcing active and passive physiotherapy on periarthritis of shoulder.

Objective To observe the effect of Weici acupuncture on shoulder-hand syndrome after acute stroke.Methods 90 cases were divided into two groups:the test group(49 cases) who were treated with Weici(a kind of acupuncture) and the control group(41 cases) who were treated with the normal acupuncture.Results The total effective ratio of the test group was 93.88%,and that of the control group was 73.17%(χ2=7.2863,P<0.01).Conclusion Weici acupuncture is more affective on shoulder-hand syndrome after acute stroke than the normal acupuncture.

目的观察功能锻炼对神经根型颈椎病恢复期的作用和效果。方法患者随机分为试验组49例和对照组48例。试验组采用体育保健学的锻炼方法结合常规手法整复,对照组只采用与试验组相同的手法整复。结果两组间基线资料无显著性差异(P>0.05)。试验组的总有效率为89.8%,对照组的总有效率为56.3%(P<0.01),试验组治疗前后症状积分明显优于对照组(P<0.01)。结论主动锻炼有助于改善神经根型颈椎病疗效。

OBJECTIVE: To determinate triptolide and wilforlide A in biological samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method and to verify the method. METHODS: After 0.4 mL blood, urine or 0.4 g hepatic tissues with internal standard were extracted by ethyl acetate, they were separated on a Allure PFP Propyl (100 mm x 2.1 mm, 5 µm) with a mobile phase of methanol-20 mmol/L ammonium acetate using gradient elution. For mass spectrometric detection, electrospray ionization (ESI⁺) in positive mode was elected and the data was collected using multiple-reaction monitoring (MRM). RESULTS: The linearity was good (r > 0.995 0) and the limit of detection was 2 ng/mL or 2 ng/g for triptolide and wilforlide A. The recovery was 61.08%-102.98%. The intra-day and inter-day precision was less than 12.58% for each biological sample, and the accuracy was 90.61%-105.80%. CONCLUSION This method is simple, convenient and good selective, and could be applied to analysis of triptolide and wilforlide A in different biological samples. And the method may provide technical support for forensic medicine identification, clinical diagnosis and treatment of tripterygium wilfordii Hook. f. poisoning.
Chromatography, High Pressure Liquid ; Diterpenes/urine* ; Epoxy Compounds/urine* ; Humans ; Oleanolic Acid/urine* ; Phenanthrenes/urine* ; Sensitivity and Specificity ; Tandem Mass Spectrometry

Objective To study whether the positive psychological capital intervention could improve the level of psychological capital and the will of retention of clinical nurses. Methods A randomized controlled trials was conducted. The control group did not take any psychological intervention;Intervention group was given psychological capital intervention, which was conducted for 7 weeks (once a week, 1-2 hours per time).It used Nurses′ Psychological Capital Questionnaire and Nurses′ Retention Intention Questionnaire to evaluate the participants before and after intervention. Results There were no statistical differences between intervention group and control group in the score of Nurses′Psychological Capital Questionnaire (84.74 ± 10.04 vs. 86.16 ± 8.57,P > 0.05 ) and Nurses′ Retention Intention Questionnaire ( 19.21±3.47 vs. 18.54±3.41,P>0.05 ) on the day before intervention. The score of Nurses′Psychological Capital Questionnaire of intervention group was 93.89 ± 7.10 on the intervention day and 93.60 ± 6.88 three months later while the control group scored 84.41 ± 6.58 and 83.92 ± 9.31.The intervention group was statistically lower than the control group (t=6.156, 5.155, P<0.05) .And the score of Nurses Retention Intention Questionnaire was 22.42±2.66 on the intervention day and 22.24±2.61 three months later while the control group scored 18.61 ± 3.08 and 19.21 ± 3.47. The intervention group was statistically lower than the control group (t=5.866, 4.292, P<0.05). Conclusions Positive psychological capital intervention can improve the the will of retention of clinical nurses.

Objective To investigate the intervention effect of integrated care including exercise therapy,example learning and psychological support to ease the hematopoietic stem cell transplantation (HSCT) related complications.Methods 40 cases were divided into the intervention group and the control group according to their hospital number,there were 20 cases in each group.The intervention group received integrated care and control group adopted traditional methods.HSCT symptoms scale was used to evaluate the intervention effects in 6 time points (the day before pretreatment,the day before HSCT,the 7th day,14th day,21th day and three months after HSCT).Results There were no statistical differences between the two groups in the score of HSCT scales on the day before pretreatment.The intervention group was statistically lower than the control group in the score of HSCT scales on the day before HSCT,the 7th day,14th day,21th day and three months after HSCT,P＜0.05.Conclusion The integrated care can reduce HSCT complications and worthybe popularizing.