1.Relationship between the peripheral dose and radioactive counts of 125I seeds detected by SPECT/CT
Xianzhi ZHAO ; Hongtao ZHANG ; Xuemin DI ; Shuangchen YANG ; Chen ZHANG ; Jinxin ZHAO ; Zezhou LIU ; Huimin YU ; Juan WANG
Chinese Journal of Nuclear Medicine and Molecular Imaging 2017;37(6):351-354
Objective To explore the relationship between the peripheral dose and radioactive counts of 125I seeds detected by SPECT/CT.Methods Six 125I seeds(1.48×107 Bq, 1.85×107 Bq, 2.22×107 Bq, 2.59×107 Bq, 2.96×107 Bq, 3.33×107 Bq) were put into the solid water phantoms respectively. SPECT/CT was applied to scan the seeds. The radioactive counts (x) at the distance of 1-15 mm from the center of seeds were recorded respectively, while the corresponding doses (y, cGy) were calculated. SPSS 18.0 was used to analyze the relationship between the radioactive counts and peripheral dose. Results There was an exponential relationship between the peripheral dose of 125I seeds and the radioactive counts. The formula was as follow: y=507.849×1.004x. Conclusion SPECT/CT can visualize the peripheral dose of 125I seed, which may provide a method for dosimetric verification after brachytherapy.
2.Dosimetric research on 125I seeds arranged in different spacing by using film dosimeter
Xuemin DI ; Hongtao ZHANG ; Jinxin ZHAO ; Zezhou LIU ; Shulei NIU ; Sui DU ; Juan WANG
Journal of Interventional Radiology 2017;26(12):1122-1125
Objective To investigate the dosimetric effect of same activity and same number of 125I seeds arranged in axial train but with different spacing.Methods A total of 27 film dosimeters were randomly and equally divided into group A,B and C.Each film was irradiated by three 125I seeds (activity of 1.48×107 Bq).The seeds were arranged in line,and their axial spacing was 1 mm,5 mm and 10 mm respectively.Image analysis software was used to draw iso-gray contour curves of 20,25,30 and 40 gray value on the films,and to calculate the areas contained by each curve.Results Multi-sample mean comparison variance analysis showed that the differences in area contained by 20 and 25 iso-gray contour curves were statistically significant between each other among the three groups (P<0.001).The difference in area contained by 30 iso-gray contour curve between group A and group B was not statistically significant (P> 0.05),while the difference in area contained by 30 iso-gray contour curve between group A and group C as well as between group B and group C was statistically significant (P<0.001).No statistically significant difference in area contained by 40 iso-gray contour curve existed between each other among the three groups (P=0.99).Conclusion Different spacing arrangement of same activity and same number of 125I seeds can directly influence the peripheral dose distribution.In specific dose range,seed-spacing of 1 mm arrangement may obtain better dose distribution than seed-spacing of 5 mm or 10 mm arrangement can do.
3.Systems Pharmacology-based Analysis of Anti-tumor Mechanism of Houttuynia cordata
Yuru ZHANG ; Xuping TIAN ; Zezhou ZHAO ; Wei XIAO ; Yonghua WANG
Chinese Journal of Experimental Traditional Medical Formulae 2022;28(14):165-171
ObjectiveTo explore the effective components, targets, and mechanism of Houttuynia cordata against lung cancer by means of systems pharmacology and further to provide a reference for the further development and clinical application of this medicinal. MethodChemical components of H. cordata were retrieved from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the active components were screened based on oral bioavailability (OB) and drug-likeness (DL). Then the potential targets were predicted, followed by enrichment analysis. Finally, sodium houttuyfonate (SH) was selected for verifying the anti-tumor mechanism. Cell counting kit-8 (CCK-8) assay was used to evaluate the effect of SH on the in vitro proliferation of two lung cancer cell lines: A549 and LLC, and the regulation of tumor-related proteins by SH was verified by Western blot. ResultA total of 7 active compounds and 352 targets of the active components were screened out. According to the enrichment analysis of targets, H. cordata had potential therapeutic effects on cancer. SH had inhibitory effect on both A549 and LLC. Western blot results showed that G1/S-specific Cyclin D1, E1 and cyclin-dependent kinase (CDK)2, CDK4 all tended to be down-regulated, and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) also changed significantly. ConclusionH. cordata has the potential anti-tumor effects by arresting the tumor cells in the G1 phase through the JAK2/STAT3 pathway.
4.Relationship of actual absorbed dose and volumetric change in patients with squamous cell carcinoma of thyroid treated by 125I radioactive seeds
Zezhou LIU ; Juan WANG ; Hongtao ZHANG ; Yansong LIANG ; Zhen GAO ; Jinxin ZHAO ; Ke XU ; Huijuan LI ; Huiming YU
Chinese Journal of Endocrine Surgery 2022;16(1):50-53
Objective:To investigate the relationship between dosimetric parameters and tumor volume change after 125I implantation for thyroid cancer and obtain better dosimetric parameters that predict the curative effect more accurately. Methods:A total of 22 consecutive patients with thyroid cancer (23 targets) who received 125I interstitial brachytherapy in Department of Oncology, Hebei General Hospital were retrospectively analyzed. All the patients received post-operative dose verification, and the D 90 (Minimum dose received by 90% target volume) was calculated. After a regular follow-up, the tumor volume reduction ratio after t months (R t) , actual absorbed dose (D 1m) , efficacy corrected absorbed dose (D 1e) , and sensitivity corrected absorbed dose (D 1s) of the first month were calculated according to the actual follow-up CT images. The statistical test was carried out by SPSS21.0. The Spearman linear analysis was applied to analyze the relationship between D 90, D 1m, D 1e, D 1s and R t, and the curve fitting was also completed. Results:The post-operative D 90, D 1m, D 1e, D 1s and R t were (129.73±14.22) Gy, (36.95±7.35) Gy, (43.45±11.32) Gy, (41.78±13.39) Gy, and (32.00±19.00) %, respectively. And the correlation coefficient were 0.692, 0.551, 0.728, and 0.858, respectively, which showed significant positive relevance between dosimetric parameters and tumor volume change ( P<0.01) , the curve fitting presented cubic function. Conclusion:The post-operative D 90, D 1m, D 1e, and D 1s can be predictors for curative effect, and D 1s is the best predictor.
5.Dosimetric analysis of radiation pneumonitis induced by 125I seed implantation for the treatment of malignant lung tumors
Ke XU ; Jinxin ZHAO ; Zezhou LIU ; Yansong LIANG ; Guohui CAO ; Xiaoli LIU ; Yan DI ; Juan WANG ; Hongtao ZHANG
Chinese Journal of Radiological Medicine and Protection 2024;44(1):13-17
Objective:To investigate the incidence of radiation pneumonitis (RP) induced by 125I seed implantation for the treatment of malignant lung tumors and analyze related dosimetric parameters. Methods:A retrospective analysis was conducted on 31 cases of malignant lung tumors treated with 125I seed implantation from January 2017 to December 2022 at Hebei Provincial Tumor Radioactive Seeds Implantation Diagnosis and Treatment Center. These cases consisted of eight patients with squamous cell carcinoma, 10 patients with adenocarcinoma, and 13 patients with metastatic cancer in other sites. At 1-6 months after treatment, these patients received postoperative chest CT scans, with the efficacy evaluated based on the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1), including the objective response rate (ORR) and the disease control rate (DCR). The efficacy of RP was evaluated using the Radiation Therapy Oncology Group (RTOG) criteria. Postoperative dosimetric parameters, including D90 (minimum peripheral dose received by 90% of the target volume), V8 (percentage of lung volume receiving 8 Gy), V32 (percentage of lung volume receiving 32 Gy), and Dmean (mean radiation dose) of the affected lung, were statistically analyzed. The relationships of the RP occurrence with postoperative D90, V8, V32, and Dmean were analyzed by comparison with relevant external radiotherapy data, to identify the parameters that are correlated closely with RP occurrence. Results:All the patients underwent successful surgeries. The postoperative efficacy evaluation after six months showed complete response (CR) in 11 cases, partial response (PR) in 11 cases, stable disease (SD) in eight cases, and progressive disease (PD) in one case, with an overall response rate (ORR) of 71.0%, and a disease control rate (DCR) of 96.8%. Three patients suffered RP, with an incidence rate of 9.7%. Postoperative V8, V32, and Dmean could not serve as predictive indicators for RP. Follow-up observation revealed that three RP cases (3/5) exhibited postoperative D90 exceeding 170 Gy and no RP cases (0/26) showed postoperative D90 below 170 Gy. Conclusions:In the treatment of malignant lung tumors with 125I seed implantation, there is a certain correlation between RP and postoperative D90, while there is no correlation between it and V8, V32, and Dmean.
6. Factors influencing the short-term efficacy of CT-guided 125I seeds implantation in the treatment of recurrent and metastatic tumors of head and neck
Enli CHEN ; Hongtao ZHANG ; Zezhou LIU ; Jinxin ZHAO ; Ke XU ; Yansong LIANG ; Aixia SUI ; Juan WANG
Chinese Journal of Nuclear Medicine and Molecular Imaging 2020;40(2):93-97
Objective:
To analyze the factors influencing the short-term efficacy of CT-guided 125I seeds implantation in the treatment of recurrent and metastatic tumors in head and neck.
Methods:
A total of 73 patients (61 males, 12 females; age: (59.1±11.5) years) with head and neck tumors recurrence and metastasis treated by 125I seeds implantation in Hebei General Hospital from January 2015 to April 2019 were retrospectively enrolled. The implanted seeds activity was 11.1-29.6 MBq, and the prescription dose was 80.0-145.0 Gy. CT examination was conducted 3 months after 125I seeds implantation. According to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, short-term efficacy was classified as effective (complete remission (CR), partial remission (PR)) and ineffective (stable disease (SD), progressive disease (PD)). Univariate analysis of factors affecting short-term effect (gender, age, history of radiation therapy, Karnofsky performance status (KPS) scores, pathological type, the longest diameter of tumor, implantation patterns, seeds activity, immediate postoperative dose delivered to 90% gross tumor volume (