1.Translational medicine used inZhang-Chongquan old TCM inheritance pattern academic experience
Huiping LIU ; Chongquan ZHANG ; Rong YU ; Guomin ZHANG ; Weining ZHANG ; Xianchun PU ; Fenglei WANG ; Zepu NING ; Zhi LI ; Ruicheng ZHAO
International Journal of Traditional Chinese Medicine 2014;(10):932-934
Objective To promote application and explore the old Chinese tradition of academic experience and their experience side mode.Methods In the study, the model of translational medicine was studied combined with the characteristics of Chinese medicine, taken the model from clinical to basic (experimental) to clinical research, combined with prospective and review of the clinical and research methods, with the modern information technology and other technological, and Tonifying Five Internal Organs(TFIO) byZhang-Chongquanfor treatment of coronary heart disease, vascular dementia.Results The article was Clarified the theory of TFIO byZhang-Chongquan,with clinical evidence.Conclusion The model of translational medicine can be used to summarize the academic experience.
2.Study on effect of total flavonoids from Scutellaria amoena on experimental arrhythmia.
Xiaoshan HE ; Ningna ZHOU ; Qing LIN ; Zepu YU ; Ron DAI ; Kesong AI
China Journal of Chinese Materia Medica 2010;35(4):508-510
OBJECTIVETo observe the effect of total flavonoids from Scutellaria amoena on the experimental arrhythmia.
METHODExperimental animals anesthetized with 10% chloral hydrate were evenly randomized into control group, positive control group, and low-dose, middle-dose and high-dose total flavonoids groups. The experimental arrhythmia ouabain-induced in guinea pigs and barium chloride or calcium chloride-induced in rats were observed and detected respectively. The result was converted into cumulative dosage of ouabain, in guinea pig model. In rat model, the duration of arrhythmia were detected.
RESULThold dosage of ventricular premature heat (VP) and ventricular fibrillation( VF) ouabain-induced in guinea pigs was markedly elevated, and the duration of ventricular tachycardia (VT) barium chloride-induced and VF calcium chloride-induced in rats was postponed by total flavonoids from S. amoena.
CONCLUSIONTotal flavonoids from S. amoena has obvious protective effect on drug-induced arrhythmia.
Animals ; Anti-Arrhythmia Agents ; administration & dosage ; Arrhythmias, Cardiac ; drug therapy ; Disease Models, Animal ; Female ; Flavonoids ; administration & dosage ; Guinea Pigs ; Humans ; Male ; Plant Extracts ; administration & dosage ; Rats ; Rats, Sprague-Dawley ; Scutellaria ; chemistry