With Chinas accession to the WTO, implementation of the intellectual property agreement, exemptions and reductions of tariff and cancellation of non tariff barriers, and execution of the general agreement on services and trades will exert a widespread impact on the domestic medical market. Reform of the medical and health system will become extremely urgent; competition in the market of medical services will grow increasingly fierce; management of human resources will find itself in a dilemma; and supervision and control of the medical market will turn more difficult. A thorough study of the opportunities and challenges confronting the medical industry after Chinas WTO entry will, therefore, contribute to a better understanding of the reality and adequate preparation for the challenges. It is imperative to establish the idea of lifelong learning, to always remember that "development is a golden principle"; to set up the commanding elevation of talents in the 21 st century; to speed up innovations in medical technology; and to construct a modern hospital management system.

In light of the emergence and development of the idea of people oriented management, the paper discusses the cultural pathways for people oriented management. People oriented management is a must for the progress of advanced culture; hospital culture is in essence people oriented culture; hospital culture and people oriented management are intrinsically unified; and cultural strength constitutes the hospital's perpetual competitiveness. For this reason, it is imperative to pinpoint the intrinsic demands of hospital culture and people oriented management so as to enhance the hospital's credibility and competitiveness. The following steps can be taken: ①identifying common objectives; ②fostering and upholding the hospital spirit; ③cultivating the idea of people oriented services; ④developing a "learning type" hospital; and ⑤making full use of the human resources on the basis of the "four respects".

Objective To study the symptom dimensions of Chinese patients with obsessive-compulsive disorder(OCD). Methods Symptom checklist in expert versions of Dimensional Yale-Brown Obsessive-Compul-sive Scale (DY-BOCS) was used to assess the symptom dimensions of 139 OCD patients. Results Nearly half of the patients had one dimension (50.4%). The frequency of patients with two or three dimensions was 24.5% and 14.4%. Patients with four to seven dimensions were very few and the frequency were 5.8% ,3.6% ,0.7% and 0.7% ,respectively. The most common symptom dimensions were symmetry (67.6%), contamination (43.2%) and aggressive (31.7%). The frequency of patients with miscellaneous, somatic, sex and religious, hoarding di-mension were 18.7%, 11.5% , 10.8% ,8.6% ,respectively. The frequency of male patients with symmetry dimen-sion was higher than that of the female patients(75.8%/52.1%, P<0.01), and the frequency of female patients with contamination dimension was higher than that of male patients (56.3%/36.3%, P<0.05). There were no differences in other dimensions between male and female patients. The early-onset patients had a greater of symp-toms in the symmetry dimension than late-onset patients and there were no differences between these two groups in other dimensions (77.6% vs 60.5%, P<0.05 ) . Conclusion Preliminary data suggest that the symptom di-mension approach may aid in the identification of subtype of OCD.

The study of subjects with different serum levels (mmol/L) of glucose, including NC (FPG6.1 mmol/L,

Triple-negative breast cancer (TNBC) is a subgroup of breast cancers defined by a lack of the expressions of estrogen,progesterone and HER2 receptors,with more aggressive biological and clinicopathological characteristics and a close relationship with basal-like and breast cancer susceptibility gene-1 (BRCA1)-related breast cancers.TNBC is insensitive to most available hormonal or standard therapeutic agents,associated with increased risk for distant metastases and with poorer prognosis than other types of breast cancer.A deeper insight into the biology of TNBC may lead to improved therapies and better clinical outcomes of the disease.

Diabetes mellitus has become the third threaten diseases second only to cardiovascular disease and tumor.Many re-searches demonstrated that the microRNAs(miRNAs)in blood related to the occurrence and development of diabetes melli-tus.Because of the non-invasion and repeatability of circulating miRNAs,the circulating miRNAs have a broad application prospect of diagnosis and prognosis evaluation for various types of diabetes.This overview arms to introduce the source and characters of circulating miRNA,and also the progress of circulating miRNA related to diabetes mellitus,so as to lay a foun-dation for further research.

Objective To study the characteristics of life events, coping styles and social supports in anxiety disorders patients. Methods 50 patients with generalized anxiety disorders (GAD), 44 patients with obsessivecompulsive disorders (OCD),23 patients with social anxiety disorders (SAD) and 99 healthy people were assessed by life event scale(LES),simplified coping style questionnaire(SCSQ) and social support rating scale (SSRS). Results Compared with healthy people, patients with GAD, OCD and SAD were all had higher scores of total life events (GAD 22.46±18.44;OCD 23.68±28.31;SAD 17.22±14.97;Healthy People 6.64±9.71)( F =14.216,P =0.000) and negative life events(GAD 18.76±17.99;OCD 20.02±24.98;SAD 12.00±13.16;Healthy People 4.56±7.51)( F =14.391,P =0.000).All patients were apt to choose positive styles less( F =16.505,P =0.000) and got less social supports totally ( F =26.506,P =0.000). The objective social supports( F =7.494,P =0.000)and subjective social supports ( F =26.985,P =0.000) were less and the utilization of social supports was lower ( F =13.931,P =0.000) in patients.Conclusions 1. Anxiety disorders patients often experience more or more serious life events, especially negative life events, are more likely to choose negative coping styles, and get less social supports. 2. Anxiety disorders may be related with people's characteristics of life events, coping styles and social supports.

Objective To investigate the requirment of family rehabilitation training and provide instructions and references to guide parents practising family rehabilitation training for cerebral palsy (CP) children in Shanghai.Methods300 CP children were surveyed with the Requirement Questionnaire of Family Guidance Training Program of Rehabilitation for Cerebral Palsy Children. Then 100 children out of them were selected randomly and a visiting training and guidance of rehabilitation in family was afforded.ResultsAfter providing training and guidance of rehabilitation in family, the requirement of family rehabilitation increased from 41.5% to 92.7% ( P<0.01) and the duration and the times of training were also increased ( P<0.01).ConclusionThe families having CP children in Shanghai don't understand fully about the family rehabilitation. The visiting training and guidance program will be helpful for CP children having complete rehabilitation and coming back to society.

Objective To investigate the effect of vibroacoustic therapy on the behavioral problem for children with cerebral injury. ethods 20 cerebral injury children (aged 6~8 years) with behavioral problem judged with Conners Parent Symptom Questionnaire (PSQ) ccepted vibroaacoustic therapy. Their PSQ scores were reviewed before and after treatment. Results Comparing with the norm, the scores f conduct problems, learning problems, anxiety and impulsivity-hyperactivity were higher in cerebral injured boys, while the scores of hysical symptoms and anxiety were higher in girls. The scores of learning problem, anxiety, impulsivity-hyperactivity and hyperactivity index educed after the vibroacoustic therapy (P<0.05). Conclusion Vibroacoustic therapy can alleviate the behavioral problems of children ith cerebral injury.

Objective To study the effect of small interfering RNA targeted on Apollon for proliferation on pancreatic cancer cells and its possible acting mechanism.Methods The small interfering RNA targeted on apollon in our previous study was transfected to the cells using LipofectamineTM 2000,after 48 hours transtection.The inhibitory effects of small interfering RNA targeted on Apollon (Apollon siRNA)on cell proliferation were detected by WST-8.Their inhibition rate and IC50 were calculated.The percentage of apoptosis cells were determined by flow cytometry.The expression of Apollon mRNA was analyzed by real time fluorescent quantitative reverse transcription polymerase chain reaction.The Apollon protein ex-pression levels were detected by western blotting.Results Apollon siRNA could effectively inhibit the proliferation of pan-creatic cancer cell.The amount of apoptotic cells increased significantly.The early apoptotic rate was 37.1%,and the RT-PCR results showed that the relative expression levels of Apollon mRNA were down-regulate,and shows a dose-effective-ness relations.The protein expression levels were decreased by Apollon siRNA.Conclusion Apollon siRNA can effectively inhibit the proliferation of pancreatic cancer cell.The mechanism may be work together to promote pancreative cancer cell early apoptosis and decreased the expression levels of gene and protein,which provides a novel potential approach for treat-ment of target therapy of pancreatic cancer.