Objective To analyze the effect of different educational models on oral health education and health promo-tion among middle school students. Methods Junior students from January to June 2011 as the object of study average from 3 middle school in Xixiang street Baoan District were randomly selected, that's each school selected 101 students, and male to female ratio was about 1:1. The students were randomly divided into in three groups, form-teacher model group (group A), mother-model group (group B) and control group (group C). After education, measured the 3 groups students' oral hygiene indexes and gingival indexes before and after 3 months, in order to compare and judge the effect of different educational models. Results According to analyze oral hygiene index, gingival index and mastery of knowl-edge on oral health education and promotion of A,B,C group, group A and B were better after education, but they were worse than group C (P all<0.05). After education in knowledge, passing percent of group A was 89.11%, while group B and C were 72.43% and 52.48%. It was indicated that group A and B were both better than group C (P all < 0.01). Conclusion Form-teacher model and mother-model education on oral health education and promotion are significant results, both of whom are competitive advantage and practical significance in clinical trials.