Objective To evaluate the therapeutic effect of radiofrequency endovenous obliteration (RFO) on superficial varicosities in lower extremity in the elderly. Methods The clinical data of 35 elderly patients (43 limbs) with primary great saphenous varicose vein, who were treated with RFO (20 limbs) or RFO in combination with high ligation procedures (23 limbs), were analyzed retrospectively. The therapeutic effects were evaluated at 1-3 years after RFO by the improvement of clinical symptom and signs, as well as results of color Doppler ultrasonography. Results Compared with single RFO group, the obstruction rate of great saphenous vein was higher [21(91.3%) vs. 14(70.0%), χ2 =5.467, P < 0. 05], and the recanalization rate was lower [2(8.7%) vs. 8(30.0%),χ2=4.251, P<0.05] in RFO combined with high ligation group. The recurrence rate of local varicose veins was lower[0 vs. 4(20. 0%),χ2 =7. 030, P<0. 013 in RFO plos high ligation group than in single RFO group. Conclusions RFO is an effective treatment with less trauma, more safety and less scars. Combined with high ligation procedure, the effectiveness may be better.

OBJECTIVE The N-methyl-D-aspartate(NMDA)receptor has been shown to be strongly associ-ated with rapid antidepressant effects.GW043 is a com-pound with a novel structure that we designed and syn-thesized to act on the NMDA receptor(NMDAR).METH-ODS In this study,we first confirmed the target of GW043 using a receptor binding assay.We observed the effect of GW043 on NMDAR currents in vivo and in vitro assays using a membrane clamp technique with a view to characterizing the function of GW043.We investi-gated the antidepressant effect of GW043 in rodent behavioral models such as FST,TST and CUMS.Fur-thermore,we explored the mechanism of GW043 onset using Western blotting,BrdU staining,Golgi staining and electrophysiological techniques.RESULTS GW043 interacts with high affinity only at the NMDAR.Electro-physiological studies have indicated that GW043 is a par-tial agonist of NMDAR.Meanwhile,behavioral experi-ments were conducted to confirm the antidepressant effect of GW043 in rodents.The mechanism study found that GW043 regulate synaptic plasticity through LTP and BDNF/mTOR pathways and increase the number of new-born neurons to cause antidepressant effects.GW043,a partial agonist of NMDAR,reversed depression-like behav-ior in rats by modulating synaptic plasticity,suggesting an antidepressant effect.CONCLUSION The results suggest that GW043 is a partial agonist of NMDA recep-tors and has significant antidepressant effects.

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck region. NPC has the characteristics of insidious onset, strong invasiveness and early lymph node metastasis. A variety of signaling pathways play a role in the invasion and metastasis of nasopharyngeal carcinoma, but the specific mechanism has not yet been fully elucidated. Recent studies have found that DNA methylation of nasopharyngeal carcinoma-related genes can affect the invasion and metastasis of nasopharyngeal carcinoma through a variety of signaling pathways including Wnt/β-catenin, PI3K/AKT and MAPK signaling pathways. This article reviews the specific mechanism of DNA methylation affecting the invasion and metastasis of nasopharyngeal carcinoma through the above-mentioned signaling pathways.