Objective To investigate the safety treatment of partially embolizing spleenomegaly in children. Methods Forty two children aged 1-15 with spleenomegaly were treated through staged partial splenic embolization (PSE). The first embolized scope of spleen was 30%-40% with the second being 30%-40% at 1 or 2 months later in order to achieve the goal of getting rid of hypersplenia and improving the splenic function. Results The adverse effects of splenic embolisation were slight with short duration of fever and stomachache and with efficient control of hypersplenia and its correlative basic diseases except one case of splenic abscess.Conclusions Spleenomegaly in Children can be more safely and more efficiently cured through staged PSE.

Objective To observe the difference of efficacy of three different treatment of internal fixation of intervetebral crasis on cervical spondylosis (spinal cord) .Methods From January 2009 to January 2013 ,There are 167 cases of patients admitted to hospital from cervical spondylosis (spinal cord ) ,randomly selected different fusion fixation methods are divided into three groups :in the first group ,there were 55 patients treated with autologous iliac bone graft fusion plate fixation ;in the second group , there were 60 patients treated with zero profile material PEEK interbody fusion with autologous bone graft ;in the third group ,the 52 patients were treated with the PEEK material MC + self‐locking cervical interbody fusion with autologous bone graft .Observa‐tion and comparison indicators include :spinal cord function JOA scores before and after surgery ,surgical segment intervertebral height and cervical curvature condition .Results Follow‐up lasted from 13 to 50 months ,the average length was 26 months .The difference in operation time ,blood loss during surgery analysis ,wherein the first group and the second or third group of three groups was statistically significant (P<0 .05) ,the difference between the second group and the third group was not statistically significant (P>0 .05) .In the first group ,there were 17 patients had transient throat discomfort and symptom disappeared 48 hours later ;dysphagia relieved or disappeared in one week ;there were two cases of screws and titanium loosen one week after operation , and were treated with immediate revision surgery .In the second ,third group ,there were 19 cases and 13 cases showed temporary throat discomfort disappeared within 48 hours after surgery respectively ,there was no dysphagia .No patient experienced cerebrospi‐nal fluid leakage ,hematoma and wound infection .The postoperative JOA scores spinal cord function (17 points France) ,surgical segmental cervical intervertebral height and curvature of three groups improved significantly compared with preoperative evaluation index ,and there was no significant difference among three groups (P>0 .05) .In the last follow‐up ,the interbody fusion rates of the first ,second and third groups were 67 .1% ,66 .3% and 65 .9% ,the difference between groups was not statistically significant (P>0 .05) .Conclusion Anterior decompression and interbody fusion locking device applications showed good performance in maintai‐ning the intervertebral height segment surgery ,rehabilitation cervical curvature ,and promote bone fusion with autogenous titanium plate fixation comparison .Patients can get a good surgery ,and the former has a simpler surgical fixation method ,shorter time ,less bleeding and less complications .

Objective: To investigate the spatial clustering characteristics of varicella public health emergency events in Nanjing City from 2017 to 2022, so as to provide the evidence for the development of varicella prevention and control strategies. Methods: Data of varicella public health emergency events in Nanjing City from 2017 to 2022 were collected through Emergency Public Health Management Information System of Chinese Disease Prevention and Control Information System. The software ArcGIS 10.2 was employed for trend-surface analysis, spatial autocorrelation analysis and hotspot analysis to understand the spatial clustering characteristics of varicella public health emergency events. Results: A total of 84 varicella public health emergency events were reported in Nanjing City from 2017 to 2022, with an average attack rate of 2.53% (2 558 cases). Ⅳ-level events were predominant, accounting for 90.48% (76 events). The trend-surface analysis showed lower incidence of varicella public health emergency events in the west of Nanjing City and higher in the east, and lower in the north and higher in the south. The global spatial autocorrelation analysis showed that there was a positive spatial correlation in varicella public health emergency events in 2017 and 2019, indicating spatial clustering (P<0.05). The hot spots were Jiangning District, Gaochun District, Yuhuatai District and Jianye District. Conclusion The incidence of varicella public health emergency events in Nanjing City from 2017 to 2022 has spatial aggregation, with a concentration in suburban areas such as Jiangning District and Gaochun District.

The clinical data and follow-up information of 4 pediatric patients with pancreatic solid pseudopapillary neoplasm (SPN) admitted in the First Affiliated Hospital of Harbin Medical University between January 2000 and January 2016 were retrospective reviewed.Four patients were all girls aged 8-13 years.All cases were treated with surgical resection and the diagnosis was confirmed histopathologically.Patients were followed up for up to 6 years,and there was no recurrence detected.Pancreatic SPN in children is a potentially malignant borderline tumor.Complete surgical resection is the only option for this disease,and spleen preserving pancreatectomy is the first choice of operation with satisfactory results.

Objective To explore the value of terminal ileum suspension in the treatment of low rectal cancer.Methods 80 patients with low rectal cancer who underwent laparoscopic operation in our hospital from June 2015 to February 2017,were randomly divided into two groups:the control group (group C) and the test group (group T),40 cases in each group.In group C,laparoscopic radical resection of rectal cancer (Dixon) was performed and in group T Dixon was combined with terminal ileum suspension.Peripheral blood nutritional indicators (total plasma protein,albumin,pre-albumin,transferrin) and major electrolytes of two groups were observed 1 day before operation and 1,3 and 7 days after operation.The two groups were compared in terms of first exhaust time,postoperative hospital stay,total costs for hospitalization,postoperative discomforts and complications.Results There were no statistical differences in the levels of nutrition indicators and electrolytes between them (P ＞ 0.05) and neither it was with first exhaust time,hospital stay,total costs of hospitalization,incidence of postoperative discomforts and complications (P ＞ 0.05).The re-operation rate of group T with anastomotic leak was significantly lower than group C (P ＜ 0.05).Conclusion Terminal ileal suspension does not affect patients' postoperative recovery without increasing the patient's suffering and economic burden,and can effectively reduce the reoperation rate caused by anastomotic leak.It is easy to operate.

Objective To study the relationship between circulating tumor cells(CTCs) in peripheral blood of the pa‐tients with hepatocellular carcinoma (HCC) and its metastasis and prognosis .Methods 35 patients with hepatocellular carci‐noma were collected as the research objects .CTCs density were enriched through gradient centrifugation and negative‐immu‐nomagnetic methods ,then the cells were detected by chromosome fluorescence in situ hybridization combined with immunofluo‐rescence tests to identify CTCs .The clinical characters were recorded and the data were statistically analyzed .Results All the patients were detected CTC positive .The number of CTC was (4 .1 ± 2 .5) .The patients were divided into 2 groups .Group Ⅰincluded patients whose CTCs were <5 ,and others were included in group Ⅱ .The difference between number of group I and group Ⅱ had significant significance(P=0 .001);Metastasis had nothing to do with patients′sex and age(P=0 .581 ,0 .531);The number of CTCs was related to metastasis and prognosis(P=0.024 ,0.01) ,and there was significant statistic significance between group I and groupⅡ .Conclusion The number of CTCs was related to tumor metastasis .The tumor may be more prone to occur metas‐tasis and may had worse prognosis ,and the patients may had shorter life time when the number of CTCs was≥5 .

Objective:To report our experience in diagnosis and treatment of posterior atlantoaxial dislocation with odontoid retrolisthesis.Methods:A retrospective study was conducted of the 5 patients who had been treated from July 2012 to August 2018 at Department of Orthopaedics, General Hospital of Southern Theater Command for posterior atlantoaxial dislocation. They were 4 men and one woman, aged from 34 to 67 years (average, 47 years). All of them had a history of trauma. Of them, 4 were complicated with odontoid fracture and one with congenital free os odontoideum. Their posterior atlantoaxial dislocation ranged from 3 to 9 mm (average, 6 mm). By the American Spinal Injury Association (ASIA) grading system, their preoperative spinal injury was rated as grade B in one, as grade C in 3 cases and as grade D in one. All the 5 patients underwent skull traction at 10° flexion. Surgical trans-oralpharyngeal atlantoaxial reduction and internal fixation was performed for the one patient whose reduction had not been achieved by traction while posterior atlantoaxial screw-rod fixation or anterior odontoid screwing was conducted for the 4 patients whose reduction had been achieved by traction. The distance of posterior atlantoaxial dislocation was measured to evaluate their reduction and ASIA grade system was used to assess their spinal function after operation.Results:The postoperative distance of posterior atlantoaxial dislocation was 0 mm, showing a reduction rate of 100%. The 5 patients were followed up for 6 to 36 months (average, 15 months). By the ASIA grade system, the postoperative functional recovery of the spine was grade D in 4 cases and grade C in one. No implant loosening or breakage occurred.Conclusion:As a kind of high-energy hyperextension injury, posterior atlantoaxial dislocation is rare in clinic, but an appropriate treatment can be adopted to deal with its different clinical types to achieve good outcomes.

Objective To investigate the prevalence of suspected myopia among students and to examine the relationship between time spent on physical exercise,sleep,homework and suspected myopia.Methods A total of 8 030 primary and secondary school students from 4th to 12th grades were selected from the National Student Constitution and Health Survey (NSCHS) in Anhui province in 2014.Time spent on exercise,sleep and homework per day were collected using a self-administrated questionnaire.Visual acuity was examined using the Standard Logarithmic Visual Acuity Chart.Results The overall prevalence of suspected myopia was 69.03％.Prevalence rates of suspected myopia appeared higher in girls,in urban students,with the highest in the 16 to 18 year-old groups.Results from the multiple logistic regression analysis showed that the amount of time spent on physical exercise,sleep and homework per day were all significantly associated with suspected myopia.Suspected myopia was associated with longer time on physical exercise among students aged 8 to 12 years (OR=0.80,95％CI:0.64-0.99),and longer sleep time among students in the age groups of 13 to 15 years and 16 to 18 years (OR=0.73,95％CI:0.56-0.94;OR=0.38,95％CI:0.21-0.68,respectively).Longer time spent on homework significantly increased the risk of suspected myopia among students in the age groups of 8 to 12 years and 13 to 15 years (OR=1.41,95％CI:1.11-1.79;OR=1.74,95％ CI:1.36-2.23,respectively).Conclusion Suspected myopia appeared common among students.Comprehensive intervention programs focusing on sufficient physical exercise and sleep but less homework might help to prevent myopia among students at different ages.

Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.
Autoantibodies ; blood ; immunology ; Biomarkers, Tumor ; blood ; immunology ; Humans ; Immunotherapy ; Neoplasms ; blood ; therapy ; Tumor Microenvironment