Novel therapeutic approaches targeting key genes and regulatory molecules of hepato-cellular carcinoma(HCC)have gradually been carried out in clinical practice.Hypoxia-inducible factor(HIF),as a critical factor for hepatocellular carcinoma cells to adapt to the hypoxic microenvi-ronment,mediates changes in the transcription of many genes.HIF has a wide range of target genes and can promote metabolic reprogramming,angiogenesis,invasion and metastasis,and immune es-cape of cancer cells by regulating various signaling pathways.Hypoxia-inducible factor 1α(HIF-1α),as the main member of the HIF family,can provide new ideas and insights for exploring potential tar-gets for HCC treatment.

Novel therapeutic approaches targeting key genes and regulatory molecules of hepato-cellular carcinoma(HCC)have gradually been carried out in clinical practice.Hypoxia-inducible factor(HIF),as a critical factor for hepatocellular carcinoma cells to adapt to the hypoxic microenvi-ronment,mediates changes in the transcription of many genes.HIF has a wide range of target genes and can promote metabolic reprogramming,angiogenesis,invasion and metastasis,and immune es-cape of cancer cells by regulating various signaling pathways.Hypoxia-inducible factor 1α(HIF-1α),as the main member of the HIF family,can provide new ideas and insights for exploring potential tar-gets for HCC treatment.