1.Phenolic acid derivatives from Bauhinia glauca subsp. pernervosa.
Qiaoli ZHAO ; Zengbao WU ; Zhihui ZHENG ; Xinhua LU ; Hong LIANG ; Wei CHENG ; Qingying ZHANG ; Yuying ZHAO
Acta Pharmaceutica Sinica 2011;46(8):946-50
To study the chemical constituents of Bauhinia glauca subsp. pernervosa, eleven phenolic acids were isolated from a 95% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, MCI, Sephadex LH-20, and semi-preparative HPLC. By spectroscopic techniques including 1H NMR, 13C NMR, 2D NMR, and HR-ESI-MS, these compounds were identified as isopropyl O-beta-(6'-O-galloyl)-glucopyranoside (1), ethyl O-beta-(6'-O-galloyl)-glucopyranoside (2), 3, 4, 5-trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside (3), 3, 4, 5-trimethoxyphenyl-beta-D-glucopyranoside (4), gallic acid (5), methyl gallate (6), ethyl gallate (7), protocatechuic acid (8), 3, 5-dimethoxy-4-hydroxybenzoic acid (9), erigeside C (10) and glucosyringic acid (11). Among them, compound 1 is a new polyhydroxyl compound; compounds 2, 10, and 11 were isolated from the genus Bauhinia for the first time, and the other compounds were isolated from the plant for the first time. Compounds 6 and 8 showed significant protein tyrosine phosphatase1B (PTP1B) inhibitory activity in vitro with the IC50 values of 72.3 and 54.1 micromol x L(-1), respectively.
2.Application of precise radiotherapy in the treatment of cancer in elderly patients
Wu ZHANG ; Xiaojun ZHUANG ; Fen WANG ; Guanghong LIU ; Zengbao XING
Chinese Journal of Geriatrics 2018;37(6):680-682
Objective To explore the clinical effect of precise radiotherapy in the treatment of cancer in elderly patients. Methods We selected 88 elderly patients with advanced cancer at our hospital from January 2012 to December 2015.The patients were assigned into a control group(n=44) treated with conventional radiation therapy and an intervention group (n=44)receiving precise radiation therapy.Clinical effects and treatment reactions and adverse events were compared between the two groups. Results The total effective rate was higher in the intervention group than in the control group ,but the difference was not significant [40.9%(18/44)vs 56.8%(25/44) ,χ2= 2.228 ,P =0.135] .The control rate of clinical diseases was higher in the intervention group [77.3%(34/44)]than in control group[56.8%(25/44)](χ2= 4.166 ,P= 0.041).The incidence of adverse reactions was significantly lower in the intervention group [43.2%(19/44 )] than in the control group [68.2%(30/44)] ,(χ2= 5.572 ,P = 0.018 ). Conclusions Precise radiotherapy has a precisely clinical efficacy and a lower incidence of adverse events. It is worth recommending and generalizing.
3.Chalcones from Bauhinia glauca subsp. pernervosa.
Zengbao WU ; Bin WANG ; Yuying ZHAO ; Xiuwei YANG ; Hong LIANG
China Journal of Chinese Materia Medica 2009;34(13):1676-1678
OBJECTIVETo study the chemical constituents of Bauhinia glauca subsp. pernervosa.
METHODThe coulis of B. glauca subsp. pernervosa were extracted with 95% EtOH at room temperature. The compounds were isolated and separated by chromatographic techniques, and structures were identified by spectroscopic methods.
RESULTSeven chalcones were isolated and identified: butein-4-methyl ether (1), isoliquiritigenin (2), butein (3), isoliquiritigenin-2'-methyl ether (4), 2',4'-dihydroxychalcone (5), isoliquiritigenin-4-methyl ether (6), 4-hydroxy-2',4'-dimethoxychalcone (7).
CONCLUSIONCompounds 1, 3, and 7 were isolated from the genus Bauhinia for the first time, the other compounds were obtained from this plant for the first time.
Bauhinia ; chemistry ; Chalcones ; chemistry ; isolation & purification ; Drugs, Chinese Herbal ; chemistry ; isolation & purification