Combined Modality Therapy ; Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Integrative Medicine ; Lichen Planus, Oral ; classification ; diagnosis ; therapy ; Medicine, Chinese Traditional ; Phototherapy ; Phytotherapy

Humans ; Integrative Medicine ; Medicine, Chinese Traditional ; Oral Medicine

Humans ; Leukoplakia, Oral ; diagnosis ; therapy ; Lichen Planus, Oral ; diagnosis ; therapy ; Mouth Neoplasms ; prevention & control ; Oral Submucous Fibrosis ; diagnosis ; therapy ; Precancerous Conditions ; diagnosis ; therapy

Aged ; Aged, 80 and over ; Dental Care for Aged ; Humans ; Mouth Diseases ; diagnosis ; drug therapy ; Mouth Mucosa ; pathology

Erythroplasia ; diagnosis ; epidemiology ; therapy ; Humans ; Leukoplakia, Oral ; diagnosis ; epidemiology ; therapy ; Mouth Mucosa ; pathology

Acquired Immunodeficiency Syndrome ; diagnosis ; therapy ; Female ; Humans ; Male ; Syphilis ; diagnosis ; therapy

Humans ; Leukoplakia, Oral ; genetics ; Lichen Planus, Oral ; genetics ; Polymorphism, Single Nucleotide

Candidiasis, Oral ; diagnosis ; drug therapy ; microbiology ; Humans

Inflammasome is a multi-protein complex which plays an important role in innate immune defense,and can adjust the activation of caspase-1 and promote the production of cytokines. NLRP3 is an important member of inflammasome Nod-like receptor(NLR)family,and its activation and expression occur mainly in macrophages and dendritic cells. NLRP3 can sense the pathogen associated molecular patterns(PAMPs)and damage associated molecular patterns(DAMPs)and initiate the inherent immune response,which plays an important role in the pathogenesis of autoimmune diseases. This article reviewed the advances in study on NLRP3 in autoimmune diseases.

Objective To examine the inhibitory effect of Chinese herbal Compound Dongju on 4-nitroquinoline 1-oxide(4NQO)-induced tongue carcinogenesis in rats. Methods A total of 85 Wistar rats were divided into four groups: model group(n=35),administration group(n=35),normal control group(n=5) and herb control group(n=10).4NQO dissolved in drinking water was administered orally to induce tongue carcinogenesis in rats.The herb compound was injected into the stomach of the rats during oral carcinogenesis.Rats were sacrificed at 9,13,20,24 and 32 weeks from the beginning of the experiment.The tongues of the rats were dissected for gross and histological assessment,and SP immunohistochemical method was also employed to detect the expression of cyclin D1 in the specimens. Results Compared with the model group,the incidence of dysplasia and the positive rate of cyclin D1 were suppressed by Compound Dongju(P