Excessive fructose intake can induce metabolic syndrome and increase serum uric acid levels.Uric acid levels are high in types of fructose-induced metabolic syndrome and may play a pathogenic role in the progression of these diseases.In this review,we focus on the role of uric acid in fructose-induced metabolic syndromes.

This article elaborates on the problem of nursing action accountability,that is,ethical accountability and law accountability.Through two vcrdict examples it gives furthor explanation of nursing action accountability.Therefore,nurses should take the patients' interest into first account and closely bond the internal restraining system-ethical accoantability and the external monitoring system-law accountability together,then they can protect their legitimate right and provide high quality of care for patients.

Minerals and trace elements are a general name for a variety of elements that constitute human tissues and maintain normal physiological functions. The single-nucleotide polymor-phism ( SNP) can affect the metabolism, disposition and effect of minerals and trace elements, causing changes in body function. In this review, we will summarize pharmacogenomics research based on the current knowledge from minerals and trace ele-ments.

The metagenomic DNA was extracted from the deep sea sediment with the depth of 900m of Prydz Bay, Antarctic. A lipase gene (lip3) with the size of 948bp was cloned from the metagenomic DNA by PCR with the primers designed. The deduced Lip3 protein was composed of 315 amino acids (AA) with a molecular mass of 34.577 ku. The motifs GFGNS(GXGXS)and G-N-S-M-G(GXSXG)in the AA sequences of Lip3 were found to be conserved in other lipase. They were most conserved sequence among the serine hydrolase and were necessary for the activity. A 35 ku of Lip3 was purified by Ni-NTA chelating sepharose column from the extract of recombinant E.coli Top 10F′ cell harboring a pLLP-OmpA plasmid inserted with lip3. The purified Lip3 was most active at 25℃ and kept 22% of activity at 0℃. Only 10% of activity was retained after it was incubated at 35℃ for 60 min. The optimal pH value for the Lip3 activity was 8.0. The Km value of the enzyme towards p-nitrophenyl palmitate increased with the increasing of assayed temperature. These results indicated that Lip3 was a typical alkaline cold active enzyme.

Objective:To explore the significance of multiple detector spiral CT multi-phase enhanced scan in differentiating liver tumors.Methods: A total of 141 patients, during from March 2011 to May 2015 in our hospital, pathologically diagnosed as liver tumors were selected to undergo multiple detector spiral CT multi-phase enhanced scan. The different performances and results in CT plain and enhanced scan for diagnosing liver cancer were observed and the sensitivity of CT multi-phase enhanced scan was analyzed.Results: 93 cases were found in CT plain scan; 141 cases were found in the arterial phase, 112 cases were found in portal venous phase and 108 cases were found in extension period in CT multi-phase enhanced scan. The lesion detection rate of CT plain scan was significantly lower than whichever of CT multi-phase enhanced scan(P<0.05); under CT multi-phase enhanced scan, the majority of lesions were typical imaging and could be diagnosed. Using CT multi-phase enhanced scan, the sensitivity of hemangiomas was 88.9%, abscess was 71.4%, focal nodular hyperplasia was 83.3%, primary liver cancer was 81.6%, and liver metastases was 97.8%; the total accuracy was 88.7%.Conclusion: The multiple detector spiral CT multi-phase enhanced scan can accurately identify liver tumor lesion stages, and it can contribute to further clinical treatment.

Currently,China lacks enough public health physicians and the quality of them varies much.In order to solve this problem,proving the access to public health physician is necessary.On the basis of literature research,this essay summarizes the existing problems of the access to public health physicians:improper professional education in university,curriculum setting and provision about physician registration.The essay argues that it is a feasible way to improve the access of public health physicians in China by further piloting and perfecting the unified post-graduation standardized training system,implementing curriculum reform to enhance students' practical ability and building network physician registration.

Despite detailed examinations have been performed,the etiology in about one third of ischemic strokes remain uncertain,which are called cryptogenic ischemic strokes.In the recent 2 decades,it has been found that patent foramen ovale(PFO)is closely associated with these cryptogenic strokes,and a roamber of profound studies have been performed subsequently,and a lot of new conceptions have been put forward.INs article reviews advances in research on the relationship between PFO and iscbemic stroke.influencing factors of PFO leading to ischemic stroke,as well as the diagnosis and treatment of PFO.

Objective:To analysis the clinical characteristics of pulmonary hypertension (PH) complicating pregnancy, then to explore the delivery time and the monitodng as well as the treatment during perinatal peri-od.Methods:The data of 10 cases with PH treated in our hospital from June 2005 to January 2009 were retro-spectively analyzed.Reaults:1 case was primary pulmonary hypertension(PPH) ; 9 cases were secondary PH (SPH), in which 4 cases were rheumatic heart disease and 5 cases were congenital heart diseases.3 cases were slight PH,6 cases were moderate PH, and 1 were severe group.4 cases NYHA class were Ⅰ～Ⅱ and 6 cases NYHA class were Ⅲ～Ⅳ.4 cases were term delivery,5 cases were premature delivery, and 1 got artifi-cial abortion.8 cases were cesarean section, and 1 was vaginal delivery.2 cases were very low birth weight infants, 1 infant was death and 1 mother was death.Conclusions:The patient of PPH should avoid concei-ving.For SPH patients whether to conceive depends on cardiac function, the level of pulmonary arterial pres-sure and should better get pregnancy after surgery or medication.It should terminate pregnancy in the first tri-mester for moderate or severe patients.Cesarean section is more suitable for those in the second or third tri-mester.The prognosis of the mother and neonate depends on several factors.

Angiogenesis is an important self-repair and remodeling mechanism after cerebral ischemia. It plays pivotal roles in promoting local blood circulation, protecting neurons and improving neurological function after cerebral ischemia. A variety of molecules and signal transduction pathways involved in the regulation of the process, including angiogenin, growth factors, matrix metalloproteinases, tissue kallikrein and anti-angiogenic proteins. This article reviews the roles of these molecules and signal transduction pathways in angiogenesis after cerebral ischemia.

Objective To investigate the clinical manifestations of cytomegalovirus (CMV) infection in patients with systemic lupus erythematosus (SLE). Methods Data of the consecutive cases of SLE complicated with active CMV infection including clinical manifestations, SLEDAI score, dosage of corticosteroid and immunosuppressants used for treatment,radiological and laboratory examinations were collected and analyzed.Results Among 2221 consecutive patients of SLE, 5.4%(121 cases) were diagnosed to be complicated with active CMV infection. Fever was the most common symptom, followed by serious liver function damage,respiratory symptoms,hematological abnormalities, myocarditis, and encephalopathy, accounted for 81%(98cases), 6.6%(8 cases), 4.1%(5 cases), 3.3%(4 cases), 0.8%(1 case), and 0.8%(1 case)respectively; in addition, 22 (18.2%) cases had no symptom. SLEDAI was higher than 15 in 47.1% cases, and 10-14 in 28.1% cases. 81% of patients were treated with corticosteroid, and 55.4% were treated with immunosuppressants. Ganciclovir was given once the diagnosis of active CMV infection was established. In most of the patients, active CMV infection had been controlled within 14-28 days, except 4 died and 6 gave up the therapy. Conclusion SLE with active CMV infection is common,especially in patients who are treated with corticosteroid and/or immunosuppressants. Clinical manifestations of SLE complicated with active CMV infection are generally nonspecific.In patients with unexplained fever,or liver damage,or lung disease,or active SLE patients who have no symptom but are refractory to the treatment, CMV infection should be suspected and the relevant laboratory tests should be ordered for early diagnosis and treatment.