With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

Objective To summarize the application of new assistance chemotherapy(NCT) in the surgeriable breast cancer,to study the security of NCT in the near future curative effects and the influence to surgery way.Methods The clinical date of 36 cases with Ⅰ～Ⅲ breast cancer were retrospectively analyzed. Results There are 8 examples of CCR, 19 examples of CPR,3 examples of PCR in the total cases. The total effective rate is 83.3%.There is no obvious side reaction. Conclusion As a result of the safety and effectiveness, NCT is an important way for treating breast neoplasms.

Forming are regulator of actin cytoskeleton. They are characterized with two formin homology domains. Diaphanous-related formin (DRF) is isolated as a subfamily because they have two specific domains such as CBD(GTPase binding domain) and DAD(Diaphanous-autoregulatory domain). DRF is required for a growing number of biological progresses, such as cell adhesion and motility,cytokinesis, morphogenesis, cell polarity and the transcriptional activation of serum response factor. They are closely invovled in cell signal transduction of Rho/Rock, so they play an important role in actin cytoskeleton rearrangements and the process of neoplasm invasion and matastasis. DRF should be studied further, for it will be helpful for deep revealing the mechanism of neoplasm invasion and matastasis, and may be an important basis of potential targets for clinic practice.

36 children of exotropic amblyopia, 20 of constant exotropia and 16 of intermittent exotropia, were performed multi-channel VEP examinations to find that all amplyopic eyes manifested VEPs of lower amplitude and longer latency. With full-field stimulation to both eyes, summation of VEP was absent in the group of constant exotropia while it was weakly present in the group of intermittent exotropia. With half-field stimulation, temporal retinal suppression was noted in all healthy eyes and some of the amblyopic eyes of the intermittent exotropia group while it was absent in the amblyopic eyes of the constant exotropia group.

Physico-chemical properties, density and pH of Xiaocuojiefu film were determined,and its main components, Chrysanthemum indicum L., Coptis chinensis Franch and Sophora flavescens Ait were identified by TLC.

To standardize the diagnosis and treatment of primary aldosteronism (primary aldosteronism syndrome),and to enhance the knowledge and clinical management the disease,six orgnizations,including the American Endocrine Society,the International Endocrine Society,the International Society of Hypertension,European Endocrine Society,European Society of Hypertension,Japan Endocrine Society,and the Japanese Society of Hypertension,established the "Detection,diagnosis and treatment of patients with primary aldosteronism:Endocrine Society Clinical Practice Guidelines" ,and this is the first international clinical guideline ever made by multiple international societies from allover the world for a individual disease.This paper,based on the authors' experience,introduces the diagnosis,screening,diagnosis test,complications and treatment of primary aldosteronism.

Pheochromocytoma is the catecholamine-secreting tumor arising from the adrenal medulla and extra-adrenal chromaffin cells and the important cause of endocrine hypertension, which leads to serious complications of the heart, brain and renal vascular events. The prevalence of phochromocytoma accounts for approximately 1.9% in the population with hypertension. The detection, diagnosis and treatment of pheochro-mocytoma at early stage are of uppermost importance. More efforts should be made to study the pathogenesis and management of pheochromocytoma.

Objectives:The study was designed to observe the effects of L-arginine(Arg) supplemented enteral nutrition on cellular immunological function in rats with severe head injury.Method:The severe head injury of rats was produced by gas percussion.Thirty rats were divided randomly into 3 groups(n=10): normal control group,enteral nutrition(EN)group and EN+Arg group.Rats in groups EN and EN+Arg were supplemented with tyrosine at the does of 0.8g?kg~(-1)?d~(–1)and Arg at the dose of 0.8g?kg~(-1)?d~(–1)for 7days,respectively.Blood samples were collected after 7 days.PMN phagocytosis rate was observed by phagocytosis Candida albicans count.CD4~(+)cells and CD8~(+) cells were analyzed by SABC.The concentration of serum IL-2 level was measured by radioimmunoassay.Results:Decreased cellular immunolgical function was found on 7~(th) day after severe head injury.However,CD4~(+),CD4~(+)/CD8~(+),IL-2 level and PMN phagocytosis rate in EN +Arg group were better than that in EN group.There was significant difference in each immunological index(P

Tissue or organic injuries(especially induced by ischemia/reperfusion) are often followed by inflammatory response characterized with neutrophil infiltration.Neutrophils exacerbate tissue or organic injuries by releasing elastase.Since brain injuries induced by cerebral ischemia/reperfusion,intracerebral hemorrhage,cerebral trauma also accompany infiltration of neutrophil,and elastase derived from neutrophil probably plays an important role in brain injury.