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With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

Objective To explore the clinical efficacy of laparoscope in the treatment of nulliparous women with tremendous ovarian cysts .Methods 46 cases of nulliparous women were divided into the two groups according to the operation method .23 cases in the laparoscopic surgery group received laparoscopic pneumoperitoneum needle treatment.23 cases in the open group were given the traditional open surgery .Before operation,the umbilical region and vagina of these patients were cleaned ,and antibiotics was given to the two groups .The operative time,postopera-tive bleeding,exhaust time,hospitalization time,the number of cases of postoperative pain ,menstrual conditions and recovery time of daily living activities were compared .Results The operative time of the laparotomy group was (68.3 ±12.3)min,which was significantly longer than (59.6 ±11.5)min of the laparoscopic surgery (t=4.26,P<0.05).The number of pain after surgery in the laparoscopic surgery group and laparotomy group were 11 cases,21 cases. The incidence rate of postoperative pain in the laparoscopic surgery group was 47.8%,which was significantly lower than 91.3% in the laparotomy group (χ2 =10.3,P<0.05).Conclusion Laparoscopic treatment for nulliparous women with ovarian cysts showed shorter operative time ,less blood loss ,faster exhaust time ,shorter hospital stay ,less pain and faster recovery .This surgery scheme deserved to be introduced and further studied .

CBX protein(chromoboxin protein homolog)is an important member of PcG(polycombe group proteins)family protein,and PcG protein is an epigenetic regulatory complex that exists in the form of polymeric transcriptional inhibitory complexes PRCs.PcG protein can modify the target gene to transcript chromatin and plays an important role in stem cell differentiation and tumorigenesis and metastasis.The CBX protein family is an important member of the classic PRC1.Recent studies have focused on the different functions of CBX in stem cells,further demonstrating the composition and function of CBX.From more evidence,CBX plays an important role in tumorigenesis and development.This review summarizes the current advances in the study of CBX family members in tumors.

This paper describes the existing problems in the circulation of drug management and puts forward the way to solve these problems in order to evoke a discussion among colleagues.

In this paper we report the results of 1434 differert minority college students in Yunnan in response to SCL-90 test. Results showed that the mean of every factor was from 1.56 to 2.12. The factor mean was different between male and female except the hostility, psychotism, PSDI; and factor mean of female was higher than that of male. There was no difference be- tween minority students and Han students. The factor mean of the obsession, compulsion and interpersonal sensitivity was higher in different minority students.

0, 999. Determing whether the d-or 1-isomer of MP are present in urine will helpdetermint the source of MP. In this case,the concentration of d-MP is about 11 and 10 times higherthan 1-MP in urine and liver, respectively. The results suggest that the person from whom thesamples were obtained probably had aceess to MP from an illicit source.

Objective To study the curative effect of accessory breast resection with axillary minidermato-glyph incision.Methods The clinical data of 47 patients undergoing accessory breast operation in our hospital be-tween April 2010 and June 2014 were retrospectively analyzed according to different methods of operation.They were divided into two groups:26 cases with axillary minidermatoglyph incision as the observation group and 21 cases with conventional accessory breast resection as the control group.The postoperative wound healing and incidence of com-plications were then compared.All the patients were followed up for 6 months.Self-designed questionnaire of visual simulation effects were adopted and shape, local pain and upper extremity activities were evaluated by the patients. Results The two groups had no significant difference in the unilateral average operation time (p >0.05).The bleeding volume in the observation group was less than the control group, and the average length of the incision and the average hospital stay were significantly shorter than those of the control group (p<0.05).After 6 months of fol-low-up, the basic satisfaction rate of shape of patients in the observation group was 95.15%, upper extremity activi-ty reached 100%, and the rate of local painlessness was 95.15%, both higher than the control group (p<0.05). Conclusion Accessory breast resection with axillary minidermatoglyph incision has the advantages of reliable cura-tive effect, less damage, inconspicuous local scar and no significant effect on physical activity.

OBJECTIVE:To provide reference for rational application of typeⅡpsychotropic drugs. METHODS:The applica-tion of type Ⅱ psychotropic drugs in our hospital during 2012-2014 was analyzed statistically in respects of consumption sum,con-sumption amount,DDDs,DDC,etc. The trend of the application of type Ⅱ psychotropic drugs and the reasonability of medication structure were evaluated in our hospital. RESULTS:9 type Ⅱ psychotropic drugs were used in our hospital during 2012-2014,in-cluding 5 oral preparations and 4 injections. The consumption sum of drugs during 2012-2014 were 22 551.33 yuan,31 489.95 yu-an and 57 742.87 yuan,increasing by 39.64% in 2013 and 83.37% in 2014. The number of type Ⅱ psychotropic drugs increased year by year,and the amount of estazolam was the largest and took up the first place in 3 years. DDDs of estazolam also occupied the first place in the list of DDDs. DDC of Phenobarbital tablet was the smallest. CONCLUSIONS:Type Ⅱ psychotropic drugs mainly are oral drugs and reasonable in structure in our hospital during 2012-2014. The consumption sum and amount of type Ⅱpsychotropic drugs increase reasonably year by year.